scholarly journals New approaches for the implementation of minimally invasive microelectrode arrays designed for brain-machine interfaces

Author(s):  
S. Martel ◽  
T. Fofonoff
2005 ◽  
Vol 11 (1) ◽  
pp. 52-56 ◽  
Author(s):  
Fumihiko Fujita ◽  
Rie Fujita ◽  
Takashi Kanematsu

2019 ◽  
Vol 9 (2) ◽  
pp. 19 ◽  
Author(s):  
Samuel Budoff ◽  
Kim Yano ◽  
Fernanda de Mesquita ◽  
Jhulimar Doerl ◽  
Maxwell de Santana ◽  
...  

Microelectrode implants are an important tool in neuroscience research and in developing brain–machine interfaces. Data from rodents have consistently shown that astrocytes are recruited to the area surrounding implants, forming a glial scar that increases electrode impedance and reduces chronic utility. However, studies in non-human primates are scarce, with none to date in marmosets. We used glial fibrillary acidic protein (GFAP) immunostaining to characterize the acute and chronic response of the marmoset brain to microelectrodes. By using densitometry, we showed that marmoset astrocytes surround brain implants and that a glial scar is formed over time, with significant increase in the chronic condition relative to the acute condition animal.


Micromachines ◽  
2016 ◽  
Vol 7 (9) ◽  
pp. 163 ◽  
Author(s):  
Bahareh Ghane Motlagh ◽  
May Choueib ◽  
Alireza Hajhosseini Mesgar ◽  
Md. Hasanuzzaman ◽  
Mohamad Sawan

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Michelle Armenta Salas ◽  
Luke Bashford ◽  
Spencer Kellis ◽  
Matiar Jafari ◽  
HyeongChan Jo ◽  
...  

Pioneering work with nonhuman primates and recent human studies established intracortical microstimulation (ICMS) in primary somatosensory cortex (S1) as a method of inducing discriminable artificial sensation. However, these artificial sensations do not yet provide the breadth of cutaneous and proprioceptive percepts available through natural stimulation. In a tetraplegic human with two microelectrode arrays implanted in S1, we report replicable elicitations of sensations in both the cutaneous and proprioceptive modalities localized to the contralateral arm, dependent on both amplitude and frequency of stimulation. Furthermore, we found a subset of electrodes that exhibited multimodal properties, and that proprioceptive percepts on these electrodes were associated with higher amplitudes, irrespective of the frequency. These novel results demonstrate the ability to provide naturalistic percepts through ICMS that can more closely mimic the body’s natural physiological capabilities. Furthermore, delivering both cutaneous and proprioceptive sensations through artificial somatosensory feedback could improve performance and embodiment in brain-machine interfaces.


2005 ◽  
Vol 11 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Edouard J. Trabulsi ◽  
Pankaj Kalra ◽  
Leonard G. Gomella

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