The segmentation and labeling of sub-cortical structures of interest are important tasks for the assessment of morphometric features in quantitative magnetic resonance (MR) image analysis. Recently, multi-atlas segmentation methods with statistical fusion strategy have demonstrated high accuracy in hippocampus segmentation. While, most of the segmentations rarely consider spatially variant model and reserve all segmentations. In this study, we propose a novel local patch-based and ranking strategy for voxelwise atlas selection to extend the original Simultaneous Truth and Performance Level Estimation (STAPLE) algorithm. The local ranking strategy is based on the metric of normalized cross correlation (NCC). Unlike its predecessors, this method estimates the fusion of each voxel patch-by-patch and makes use of gray image features as a prior. Validation results on 33 pairs of hippocampus MR images show good performance on the segmentation of hippocampus.
Votenet++: Registration Refinement For Multi-Atlas Segmentation