Representing Biological Aspects in Engineering Model System

Author(s):  
Laszlo Horvath
Author(s):  
László Horváth

Engineering modeling software systems have been developed during a long integration process from separated partial solutions to current modeling software platforms (MSPs). MSP is expected to provide all necessary model creation and application capabilities during integrated innovation and the life cycle of commercial and industrial products (CIP). Recently, advanced CIP is operated by component systems organized within an increasingly autonomous cyber physical system (CPS). CIP is represented by the engineering model system (EMS). EMS is driven by active contexts between the outside world and EMS, between component models of EMS, and between objects in a component model. EMS reacts to any new contribution using all formerly represented contexts. Consistent structure of contexts gives autonomous operation capability for EMS. Active contexts between the outside world and EMS make EMS sensitive to outside world changes. In the other direction, EMS can generate advice for the outside world using high level and well-organized active knowledge as context. Contributing to research in key issues around EMS and the relevant software technology, this paper introduces results in requirements against MSP capabilities to represent intelligent driving content (IDC) in EMS. A novel organized structure of IDC and continuous engineering (CE) aspects of IDC development are explained and discussed placing the main emphasis on situation awareness. Finally, a new concept is introduced in which purposeful EMS acts as the only media in communication of researchers. Specially configured MSP facilitates participation from industrial, institutional, and academic organizations. The research proceeds at the Laboratory of Intelligent Engineering Systems (IESL) in the organization of the Óbuda University.


Parasitology ◽  
1982 ◽  
Vol 85 (1) ◽  
pp. 189-216 ◽  
Author(s):  
Alison A. Newton

Viruses are frequently referred to as the supreme parasites and yet it is now more than 20 years since any paper on this topic was published inParasitology. This deficiency probably reflects the great emphasis placed during the last two decades on those aspects of virology christened by Sir Christopher Andrewes ‘dream virology’ (Andrewes, 1973), namely the molecular and genetic properties of viruses, in contrast to the more clinical and biological aspects of ‘steam’ virology. Many modern virologists select a virus as a convenient model system with which to investigate such things as genetic organization or control of transcription, with little regard for the interaction with the host cell that supports its replication. Paradoxically, it is this very emphasis on the detailed molecular mechanisms of virus replication that has now put us in a better position to understand the relationships between these highly specialized parasites and their host systems than for any other type of parasite. Recent advances in cell biology coupled with an understanding of the molecular basis of viral replicative mechanisms mean that new insight is possible into the interactions of a virus with its host. For example, we are just beginning to appreciate why a virus should infect one individual and not another, or why it should multiply only in certain tissues at certain stages of development of a multicellular organism. Indeed, study of such tropisms may frequently tell us as much about the host cell as about the virus.


Author(s):  
Benoit Leger ◽  
Luca Stringhetti ◽  
Didier Massonnet ◽  
Christophe Delaroche ◽  
Frederic Picard ◽  
...  

Author(s):  
D. C. Williams ◽  
D. E. Outka

Many studies have shown that the Golgi apparatus is involved in a variety of synthetic activities, and probably no Golgi product is more elaborate than the scales produced by various kinds of phytoflagellates. The formation of calcified scales (coccoliths, Fig. 1,2) of the coccolithophorid phytoflagellates provides a particularly interesting model system for the study of biological mineralization, and the sequential formation of Golgi products.The coccoliths of Hymenomonas carterae consist of a scale-like base (Fig. 2 and 4, b) with a highly structured calcified (CaCO3) rim composed of two distinct elements which alternate about the base periphery (Fig. 1 and 3, A, B). Each element is enveloped by a sheath-like organic matrix (Fig. 3; Fig. 4, m).


Author(s):  
Masako Osumi ◽  
Misuzu Nagano ◽  
Hiroko Kazama

We have found that microbodies appeared profusely together with a remarkable increase in catalase activity in normal alkane-grown cells of hydrocarbon-utilizing Candida yeasts, and that the microbodies multiplied by division in these cells. These features of Candida yeasts seem to provide a useful model system for studies on the biogenesis of the microbody. Subsequently, we have succeeded in isolation of Candida microbodies in an apparently native state, as judged biochemically and morphologically. The presence of DNA in the purified microbody fraction thus obtained was proved by the diphenylamine method. DNA molecule of about 15 urn in contour length was released from an isolated microbody. The physicochemical analyses of the microbody DNA revealed that its buoyant density differed from nuclear and mitochondrial DNAs. All these results lead us to the possibility that there is a novel type of DNA in microbodies.


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