Web 2.0 applications emphasize the end-user involvement to provide the content. In this new scenario, an easy to use and a highly interactive user interface (UI) is a key requirement in order to appeal the end-user. The main objective of this chapter is to introduce a model-driven engineering process to create rich Internet applications (RIA) that address the requirements that a Web 2.0 application must fulfill. To achieve this goal, an interaction model made up of two complementary models is proposed: On the one hand, an abstract interaction model, which clearly defines the interactions between the user and the system and on the other hand, a concrete RIA interaction model that specifies the semantics needed to accurately define RIA for the Web 2.0 domain. Both models are introduced inside a model-driven code generation process with the aim of producing a fully functional Web 2.0 application. To illustrate the contribution of this chapter, the approach is applied in a case study related to the Web 2.0 domain.