The aim of this paper concerns motion control and robust path tracking. An approach based on fractional prefilter synthesis was already developed. It allows tracking optimization according to the fractional derivation order, the actuators physical constraints and the control loop frequency bandwidth. The purpose of this paper is the extension of this approach to multivariable systems. A non integer prefilter synthesis methodology for square MIMO systems (Multi-Input, Multi-Output) is presented. It is based on the MIMO-QFT robust synthesis methodology, taking into account of the plant uncertainties. MIMO-QFT robust synthesis methodology is based on multiple SISO (MISO systems) synthesis by considering the loop couplings. The SISO-QFT synthesis methodology can be then used for each SISO synthesis. Then the prefilters are synthesized. The prefilter parameter optimization is founded on the prefilter output error integral minimization, taking into account of the actuators physical constraints and the tracking performance specifications. An application example is given.