Jointly Learning Kernel Representation Tensor and Affinity Matrix for Multi-View Clustering

2020 ◽  
Vol 22 (8) ◽  
pp. 1985-1997 ◽  
Author(s):  
Yongyong Chen ◽  
Xiaolin Xiao ◽  
Yicong Zhou
Keyword(s):  
Affinity Matrix ◽  
Kernel Representation

Learning task-driving affinity matrix for accurate multi-view clustering through tensor subspace learning

2021 ◽  
Vol 563 ◽  
pp. 290-308
Author(s):  
Haiyan Wang ◽  
Guoqiang Han ◽  
Junyu Li ◽  
Bin Zhang ◽  
Jiazhou Chen ◽  
...  
Keyword(s):  
Learning Task ◽  
Subspace Learning ◽  
Affinity Matrix ◽  
Tensor Subspace

scholarly journals A new affinity matrix for mineralocorticoid receptors.

1987 ◽  
Vol 262 (17) ◽  
pp. 8121-8127 ◽  
Author(s):  
M Lombes ◽  
M Claire ◽  
P Lustenberger ◽  
A Michaud ◽  
M E Rafestin-Oblin
Keyword(s):  
Mineralocorticoid Receptors ◽  
Affinity Matrix

A kernel representation for exponential splines with global tension

2009 ◽  
Author(s):  
Sven Barendt ◽  
Bernd Fischer ◽  
Jan Modersitzki
Keyword(s):  
Kernel Representation

In-silico drug screening method based on the protein–compound affinity matrix using the factor selection technique

2007 ◽  
Vol 42 (7) ◽  
pp. 966-976
Author(s):  
Sukumaran Murali ◽  
Shinichi Hojo ◽  
Hideki Tsujishita ◽  
Haruki Nakamura ◽  
Yoshifumi Fukunishi
Keyword(s):  
Drug Screening ◽  
In Silico ◽  
Screening Method ◽  
Affinity Matrix ◽  
Selection Technique

Structure of macrophage migration inhibitory factor in complex with methotrexate

2021 ◽  
Vol 77 (3) ◽  
pp. 293-299
Author(s):  
Kei Fukushima ◽  
Minoru Furuya ◽  
Takashi Kamimura ◽  
Midori Takimoto-Kamimura
Keyword(s):  
Rheumatoid Arthritis ◽  
Dihydrofolate Reductase ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Molecular Orbital Calculations ◽  
Macrophage Migration ◽  
Affinity Matrix ◽  
Nucleotide Synthesis ◽  
X Ray

Methotrexate (MTX) is an anticancer and anti-rheumatoid arthritis drug that is considered to block nucleotide synthesis and the cell cycle mainly by inhibiting the activity of dihydrofolate reductase (DHFR). Using affinity-matrix technology and X-ray analysis, the present study shows that MTX also interacts with macrophage migration inhibitory factor (MIF). Fragment molecular-orbital calculations quantified the interaction between MTX and MIF based on the structure of the complex and revealed the amino acids that are effective in the interaction of MTX and MIF. It should be possible to design new small-molecule compounds that have strong inhibitory activity towards both MIF and DHFR by structure-based drug discovery.

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