Serum cytokeratin 19 fragment 21-1 is a useful tumor marker for the assessment of extramammary Paget's disease

2017 ◽  
Vol 44 (6) ◽  
pp. 666-670 ◽  
Author(s):  
Junji Kato ◽  
Yasuyuki Sumikawa ◽  
Tokimasa Hida ◽  
Takafumi Kamiya ◽  
Kohei Horimoto ◽  
...  
Keyword(s):  
Tumor Marker ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Cytokeratin 19 ◽  
Extramammary Paget’S Disease ◽  
Cytokeratin 19 Fragment ◽  
Extramammary Paget's Disease

scholarly journals Serum Cytokeratin 18 as a Metastatic and Therapeutic Marker for Extramammary Paget’s Disease

2021 ◽  
Author(s):  
Mariko Urano-Takaoka ◽  
Hayakazu Sumida ◽  
Takuya Miyagawa ◽  
Kentaro Awaji ◽  
Kojiro Nagai ◽  
...  
Keyword(s):  
Tumor Marker ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Cytokeratin 18 ◽  
Baseline Serum ◽  
Response To Chemotherapy ◽  
Serial Serum ◽  
Adequate Management ◽  
Extramammary Paget's Disease

Extramammary Paget’s disease (EMPD) is a rare cutaneous adenocarcinoma with unfavorable prognosis once it becomes invasive. A tumor marker that reflects disease progression is required for adequate management of this disease. Cytokeratin 18 is highly expressed in many types of cancer and its soluble forms are detected by M30 (for caspase-cleaved form) and M65 (for both caspase-cleaved and intact forms) assays. Here, we report that tumor cells of EMPD in both lesional skin and lymph node metastasis are positive for CK18 immunohistochemically and the baseline serum M30 and M65 levels in metastatic EMPD patients are significantly higher than those in non-metastatic patients. In addition, serial serum M30 and M65 levels might reflect recurrence of EMPD and response to chemotherapy. These results suggest that serum CK18 levels may be a useful tumor marker for advanced EMPD.

Four cases of extramammary Paget's disease - A topographic study.

1984 ◽  
Vol 46 (5) ◽  
pp. 1118-1122 ◽  
Author(s):  
Yoshihisa FUJII ◽  
Nobuyuki SHIRAISHI ◽  
Etsuji MATSUNAGA ◽  
Susumu TAKAYASU ◽  
Toshitaka NAKAMURA
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Extramammary Paget's Disease

A Case of Extramammary Paget's Disease after Excision of Bilateral Breast Carcinoma

2007 ◽  
Vol 69 (3) ◽  
pp. 273-276
Author(s):  
Satoko KUMAZAWA ◽  
Kou DAN ◽  
Teiichi MASUDA ◽  
Kazunori URABE ◽  
Masutaka FURUE
Keyword(s):  
Breast Carcinoma ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Bilateral Breast Carcinoma ◽  
Extramammary Paget's Disease

Programmed Death-Ligand 1 and Programmed Death-Ligand 2 Expression Can Affect Prognosis in Extramammary Paget’s Disease

2021 ◽  
Vol 41 (1) ◽  
pp. 219-226
Author(s):  
AYA KAWAGUCHI ◽  
JUN AKIBA ◽  
REIICHIRO KONDO ◽  
EIJI SADASHIMA ◽  
SACHIKO OGASAWARA ◽  
...  
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Extramammary Paget's Disease
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