Hyperoncotic albumin is not effective in the treatment of peripheral oedema

2020 ◽  
Vol 64 (7) ◽  
pp. 1025-1025 ◽  
Author(s):  
Ellis Muggleton
Keyword(s):  

1987 ◽  
Vol 147 (2) ◽  
pp. 72-78
Author(s):  
Susan Faires ◽  
Mervyn Thomas ◽  
Robert Giles ◽  
Dennis Wakefield ◽  
James Yong ◽  
...  
Keyword(s):  


2005 ◽  
Vol 2 (2) ◽  
pp. 61-66 ◽  
Author(s):  
Chetan Patel ◽  
Kathleen L Wyne ◽  
Darren K McGuire


BMJ ◽  
1993 ◽  
Vol 306 (6888) ◽  
pp. 1340-1340
Author(s):  
W. MacNee ◽  
N. J Douglas


2010 ◽  
pp. 3083-3092
Author(s):  
Peter S. Mortimer
Keyword(s):  


2020 ◽  
Vol 64 (7) ◽  
pp. 1026-1027
Author(s):  
Robert G. Hahn ◽  
Randal O. Dull
Keyword(s):  


BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e023600 ◽  
Author(s):  
Igho J Onakpoya ◽  
Elizabeth T Thomas ◽  
Joseph J Lee ◽  
Ben Goldacre ◽  
Carl J Heneghan

ObjectiveTo assess the benefits and harms of pregabalin in the management of neuropathic pain.DesignRapid review and meta-analysis of phase III, randomised, placebo-controlled trials.ParticipantsAdults aged 18 years and above with neuropathic pain defined according to the International Association for the Study of Pain criteria.InterventionsPregabalin or placebo.Primary and secondary outcome measuresOur primary outcomes were pain (as measured using validated scales) and adverse events. Our secondary outcomes were sleep disturbance, quality of life, Patient Global Impression of Change, Clinician Global Impression scale, anxiety and depression scores, overall discontinuations and discontinuations because of adverse events.ResultsWe included 28 trials comprising 6087 participants. The neuropathic pain conditions studied were diabetic peripheral neuropathy, postherpetic neuralgia, herpes zoster, sciatica (radicular pain), poststroke pain and spinal cord injury-related pain. Patients who took pregabalin reported significant reductions in pain (numerical rating scale (NRS)) compared with placebo (standardised mean difference (SMD) −0.49 (95% CI −0.66 to −0.32, p<0.00001), very low quality evidence). Pregabalin significantly reduced sleep interference scores (NRS) compared with placebo (SMD −0.38 (95% CI −0.50 to −0.26, p<0.00001), moderate quality evidence. Pregabalin significantly increased the risk of adverse events compared with placebo (RR 1.33 (95% CI 1.23 to 1.44, p<0.00001, low quality evidence)). The risks of experiencing weight gain, somnolence, dizziness, peripheral oedema, fatigue, visual disturbances, ataxia, non-peripheral oedema, vertigo and euphoria were significantly increased with pregabalin. Pregabalin was significantly more likely than placebo to lead to discontinuation of the drug because of adverse events (RR 1.91 (95% CI 1.54 to 2.37, p<0.00001), low quality evidence).ConclusionPregabalin has beneficial effects on some symptoms of neuropathic pain. However, its use significantly increases the risk of a number of adverse events and discontinuation due to adverse events. The quality of the evidence from journal publications is low.



Drug Safety ◽  
2016 ◽  
Vol 39 (11) ◽  
pp. 1093-1104 ◽  
Author(s):  
Deborah Layton ◽  
Abigail L. Coughtrie ◽  
Naseer Qayum ◽  
Saad A. W. Shakir


2011 ◽  
Vol 9 (2) ◽  
Author(s):  
MU Dada ◽  
A Obadeji ◽  
AO Ajayi


2012 ◽  
Vol 46 (8) ◽  
pp. 790-791 ◽  
Author(s):  
Alexia J McSkimming ◽  
Pallavi Dham ◽  
Jacob Alexander ◽  
Anthony Dinesh
Keyword(s):  


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