Giant acquired ungual fibrokeratoma of the nail matrix

2021 ◽  
Author(s):  
Xueke Zou ◽  
Shuxia Yang
Keyword(s):  
Nail Matrix

scholarly journals AB1088 NAIL PSORIASIS: THE UNDERESTIMATED DISORDER IN PSORIASIS AND PSORIASIS ARTHRITIS. CAN ULTRASOUND AND CAPILLARY MICROSCOPY IN PATIENTS WITH NAIL PSORIASIS SPEED UP OUR DIAGNOSIS AND THERAPY?

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1833.2-1833
Author(s):  
B. C. Detlef ◽  
S. El-Nawab-Becker ◽  
M. Toellner ◽  
A. Kleinheinz ◽  
T. Witte
Keyword(s):  
Psoriasis Vulgaris ◽  
Extensor Tendon ◽  
Daily Practice ◽  
Daily Routine ◽  
Nail Psoriasis ◽  
Capillary Microscopy ◽  
Nail Matrix ◽  
Significant Difference ◽  
The Us ◽  
Nail Involvement

Background:Nail psoriasis is an extreme diagnostic and therapeutic challenge and represents an enormous physical and psychological burden for affected patients.50% of patients with psoriasis vulgaris develop nail involvement (NailPso)during the course of their disease. NailPso is the strongest predictor of psoriatic arthritis (PsA). Through the synovio-enthesial concept we have learned that there is an anatomical-pathophysiological relationship between DIP joint, extensor tendon and nail matrix. We have observed in daily practice that hypervascularization (HV) in ultrasound Power Doppler (US-PD)the nail matrix may be a pathognomonic element in its own right. There are no data on this in the literature.Objectives:Is there a difference in the ultrasound PD examination of the DIP joint and nail area and in the capillary microscopy of the corresponding nail fold in patients with psoriasis vulgaris and nail psoriasis versus patients with psoriasis vulgaris without nail psoriasis.Methods:Monocentric prospective study of all consecutive patients with psoriasis vulgaris who have come to a rheumatic practice to clarify a PsA. Inaddition to demographic data, assessments (PASI,DLQI,CASPAR,GEPARD, DAS28, SJ,TJ,FFBH), clinical examination, a standardized ultrasound PD examination and capillary microscopy of the affected fingertips in PsO patients suffering from nail psoriasis was performed as well as corresponding examinations of the 2nd and 3rd finger right in PsO patients without nail involvement.Results:79 patients could be included during the study period. Thereof 25 PsO patients without nail involvement and 44 PsO patients with nail involvement. Since the patients were examined consecutively, the difference results. There was no difference in age, BMI and sex in both groups (Pso and NailPso). The Caspar criteria as classification criteria for a PsA were positive in 65% of the NailPso patients and positive in 50% of all PsO patients without nail infestation. Hypervascularization in the US-PD examination in the area of the nail matrix could be seen significantly more frequently in NailPso compared to non-NagelPso patients. Such a difference did not exist in the HV of the extensor tendons.Capillary microscopy showed a significant difference in the number of torsions/twist capillaries in NailPso compared to Pso patients without NailPso.Hypervascularization of the nail matrix is seen significantly more frequently in patients with psoriasis of the nail than in patients without psoriasis of the nail. Such a difference does not exist in DIP joint -extensor tendon- enthesitis. At the same time, torsions are significantly more frequently seen in capillary microscopy in NailPso than in patients without NailPso.Conclusion:The US-PD examination is a simple and non-invasive procedure which can be performed routinely in daily practice. The hypervascularization of the nail matrix should also make one think of nail psoriasis in the early stage of PsO, in order to be able to start early an appropriate therapy for this very stigmatizing and therapeutically extremely difficult manifestation of PsO. It seems to occur independently of extensor tendon synovitis as an independent manifestation phenomenon.The occurrence of torsions in capillary microscopy >50 % also seems to be groundbreaking for a NagelPso, whereby capillary microscopy is a temporal challenge in daily routine.References:§ The present study (7734-BO-S2018 Ethics Commission of the MHH, Medical School Hannover, Germany) contains parts of the PhD thesis of M.TöllnerDisclosure of Interests:Becker-Capeller Detlef Grant/research support from: Novartis, Speakers bureau: Pfizer, Soham El-Nawab-Becker: None declared, Malo Toellner: None declared, Andreas Kleinheinz: None declared, Torsten Witte: None declared

scholarly journals Immunology of the Human Nail Apparatus: The Nail Matrix Is a Site of Relative Immune Privilege

2005 ◽  
Vol 125 (6) ◽  
pp. 1139-1148 ◽  
Author(s):  
Taisuke Ito ◽  
Natsuho Ito ◽  
Matthias Saathoff ◽  
Barbara Stampachiacchiere ◽  
Albrecht Bettermann ◽  
...  
Keyword(s):  
Immune Privilege ◽  
Nail Matrix ◽  
Human Nail ◽  
A Site

scholarly journals Reconstruction of complex nail matrix defect using the homodigital reverse fasciocutaneous flap

Medicine ◽  
2018 ◽  
Vol 97 (44) ◽  
pp. e12974 ◽  
Author(s):  
Yang Liu ◽  
Xiucun Li ◽  
Ruijun Li ◽  
Jiayi Zhang ◽  
Laijin Lu
Keyword(s):  
Fasciocutaneous Flap ◽  
Nail Matrix

scholarly journals The case of onychomatricoma in a 53-year-old woman

2019 ◽  
Vol 95 (2) ◽  
pp. 64-67
Author(s):  
S. V. Lishchuk ◽  
O. R. Katunina ◽  
E. A. Dubova ◽  
K. A. Pavlov
Keyword(s):  
Rare Tumour ◽  
Nail Matrix

This paper presents a case of onyсhomatricoma — a rare tumour of the nail matrix — in a 53-year-old woman.

CD13 is a marker for onychofibroblasts within nail matrix onychodermis: Comparison of its expression patterns in the nail unit and in the hair follicle

2017 ◽  
Vol 44 (11) ◽  
pp. 909-914 ◽  
Author(s):  
Ji-Hye Park ◽  
Dong-Youn Lee ◽  
Kee-Taek Jang ◽  
Sang-Yun Ha ◽  
Ghee Young Kwon ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Expression Patterns ◽  
Nail Matrix

Nail Matrix Pathology in Cronkhite–Canada Syndrome

2017 ◽  
Vol 39 (11) ◽  
pp. 860-862 ◽  
Author(s):  
Mati Chuamanochan ◽  
Napatra Tovanabutra ◽  
Pongsak Mahanupab ◽  
Sarawut Kongkarnka ◽  
Siri Chiewchanvit
Keyword(s):  
Nail Matrix

Onychomatricoma: Genome-wide analyses of a rare nail matrix tumor

2011 ◽  
Vol 64 (3) ◽  
pp. 573-578.e1 ◽  
Author(s):  
Javier Cañueto ◽  
Ángel Santos-Briz ◽  
Juan Luis García ◽  
Cristina Robledo ◽  
Pablo Unamuno
Keyword(s):  
Nail Matrix ◽  
Genome Wide

Treatment of subungual myxoma preserving the nail matrix: A case report

1998 ◽  
Vol 23 (1) ◽  
pp. 178-180 ◽  
Author(s):  
Leo M. Rozmaryn ◽  
Arnold M. Schwartz
Keyword(s):  
Case Report ◽  
Nail Matrix

Chapter-24 Partial Nail Avulsion with Nail Matrix Phenolization

2012 ◽  
pp. 337-342
Author(s):  
Somesh Gupta
Keyword(s):  
Nail Matrix
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