CD13 is a marker for onychofibroblasts within nail matrix onychodermis: Comparison of its expression patterns in the nail unit and in the hair follicle

2017 ◽  
Vol 44 (11) ◽  
pp. 909-914 ◽  
Author(s):  
Ji-Hye Park ◽  
Dong-Youn Lee ◽  
Kee-Taek Jang ◽  
Sang-Yun Ha ◽  
Ghee Young Kwon ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Expression Patterns ◽  
Nail Matrix

scholarly journals Sox9 expression in canine epithelial skin tumors

2015 ◽  
Vol 59 (3) ◽  
Author(s):  
E. Fantinato ◽  
L. Milani ◽  
G. Sironi
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Hair Follicle ◽  
Squamous Cell ◽  
Expression Patterns ◽  
Regulatory Gene ◽  
Skin Neoplasms ◽  
Stem Cell Marker ◽  
Molecular Characteristics

<p><em>Sox9</em> is a master regulatory gene involved in developmental processes, stem cells maintenance and tumorigenesis. This gene is expressed in healthy skin but even in several skin neoplasms, where its expression patterns often resembles those of the developing hair follicle. In this study, samples from eleven different types of canine skin neoplasms (squamous papilloma, squamous cell carcinoma, infundibular keratinizing acanthoma, inferior tricholemmoma, isthmic tricholemmoma, trichoblastoma, trichoepitelioma, malignant trichoepitelioma, pilomatricoma, subungual keratoacanthoma, subungual squamous cell carcinoma) were immunohistochemically stained and evaluated for <em>Sox9</em> with the aim to correlate tumor phenotype with molecular characteristics that may help to better define tumor development, contribute to its diagnosis and clinical management. Keratoacanthoma excluded, all the skin neoplasms examined showed a variable positivity to <em>Sox9</em>, especially in the basal layers, but with major intensity in neoplasms developing from the bulge region of the hair follicle, as trichoblastoma. According to our results, <em>Sox9</em> could be employed as a stem cell marker to better assess the role of stem cells in canine epidermal and follicular tumors.</p>

scholarly journals Intercellular Adhesion Molecule-1 and Hair Follicle Regression

2000 ◽  
Vol 48 (4) ◽  
pp. 557-568 ◽  
Author(s):  
Sven Müller-Röver ◽  
Silvia Bulfone-Paus ◽  
Bori Handjiski ◽  
Pia Welker ◽  
John P. Sundberg ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Adhesion Molecule ◽  
Expression Patterns ◽  
Intercellular Adhesion ◽  
Hair Follicles ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Outer Root Sheath ◽  
Cycle Dependent ◽  
Connective Tissue Sheath

Although the intercellular adhesion molecule-1 (ICAM-1) is recognized for its pivotal role in inflammation and immune responses, its role in developmental systems, such as the cyclic growth (anagen) and regression (catagen) of the hair follicle, remains to be explored. Here we demonstrate that ICAM-1 expression in murine skin is even more widespread and more developmentally regulated than was previously believed. In addition to endothelial cells, selected epidermal and follicular keratinocyte subpopulations, as well as interfollicular fibroblasts, express ICAM-1. Murine hair follicles express ICAM-1 only late during morphogenesis. Thereafter, morphologically identical follicles markedly differ in their ICAM-1 expression patterns, which become strikingly hair cycle-dependent in both intra- and extrafollicular skin compartments. Minimal ICAM-1 and leukocyte function-associated (LFA-1) protein and mRNA expression is observed during early anagen and maximal expression during late anagen and catagen. Keratinocytes of the distal outer root sheath, fibroblasts of the perifollicular connective tissue sheath, and perifollicular blood vessels exhibit maximal ICAM-1 immunoreactivity during catagen, which corresponds to changes of LFA-1 expression on perifollicular macrophages. Finally, ICAM-1-deficient mice display significant catagen acceleration compared to wild-type controls. Therefore, ICAM-1 upregulation is not limited to pathological situations but is also important for skin and hair follicle remodeling. Collectively, this suggests a new and apparently nonimmunological function for ICAM-1-related signaling in cutaneous biology.

Proteoglycan expression patterns in human hair follicle

2007 ◽  
Vol 158 (2) ◽  
pp. 234-342 ◽  
Author(s):  
S. Malgouries ◽  
S. Thibaut ◽  
B.A. Bernard
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Expression Patterns ◽  
Human Hair Follicle

scholarly journals Essential Role of STAT3 Signaling in Hair Follicle Homeostasis

2021 ◽  
Vol 12 ◽  
Author(s):  
Kosuke Miyauchi ◽  
Sewon Ki ◽  
Masao Ukai ◽  
Yoshie Suzuki ◽  
Kentaro Inoue ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Inflammatory Responses ◽  
Expression Patterns ◽  
Critical Role ◽  
Dominant Negative ◽  
Cell Specification ◽  
Stat3 Signaling ◽  
Specific Pathogen ◽  
Transcription 3

Dominant-negative mutations associated with signal transducer and activator of transcription 3 (STAT3) signaling, which controls epithelial proliferation in various tissues, lead to atopic dermatitis in hyper IgE syndrome. This dermatitis is thought to be attributed to defects in STAT3 signaling in type 17 helper T cell　specification. However, the role of STAT3 signaling in skin epithelial cells remains unclear. We found that STAT3 signaling in keratinocytes is required to maintain skin homeostasis by negatively controlling the expression of hair follicle-specific keratin genes. These expression patterns correlated with the onset of dermatitis, which was observed in specific pathogen-free conditions but not in germ-free conditions, suggesting the involvement of Toll-like receptor-mediated inflammatory responses. Thus, our study suggests that STAT3-dependent gene expression in keratinocytes plays a critical role in maintaining the homeostasis of skin, which is constantly exposed to microorganisms.

Hair follicle predetermination

2001 ◽  
Vol 114 (19) ◽  
pp. 3419-3431 ◽  
Author(s):  
Andrei A. Panteleyev ◽  
Colin A. B. Jahoda ◽  
Angela M. Christiano
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Expression Patterns ◽  
Molecular Data ◽  
Hair Shaft ◽  
Outer Root Sheath ◽  
Cellular Kinetics ◽  
Root Sheath ◽  
Bulge Region ◽  
Disc Cells

Recent genetic and molecular studies of hair follicle (HF) biology have provided substantial insight; however, the molecular data, including expression patterns, cannot be properly appreciated without an understanding of the basic cellular rearrangements and interactions that underpin HF cyclic transformations. We present a novel interpretation of the major cellular processes that take place during HF cycling – the hypothesis of hair follicle predetermination. This hypothesis is an extension of previous models of HF cellular kinetics but has two critical modifications: the dual origin of the cycling portion of the HF, and the timing of the recruitment of stem cells. A compilation of evidence suggests that the ascending portion of the HF (hair shaft and inner root sheath) arises not from bulge-located HF stem cells that contribute to the formation of only the outer root sheath (ORS), but instead from the germinative cells localized in the secondary hair germ. In middle anagen, upon completion of the downward growth of the HF, cells derived from the bulge region migrate downward along the ORS to reside at the periphery of the HF bulb as a distinct, inactive cell population that has specific patterns of gene expression - ‘the lateral disc’. These cells survive catagen-associated apoptosis and, under the direct influence of the follicular papilla (FP), transform into the hair germ and acquire the ability to respond to FP signaling and produce a new hair. Thus, we propose that the specific sensitivity of germ cells to FP signaling and their commitment to produce the ascending HF layers are predetermined by the previous hair cycle during the process of transformation of bulge-derived lateral disc cells into the secondary hair germ.

scholarly journals Atlas of Prenatal Hair Follicle Morphogenesis Using the Pig as a Model System

2021 ◽  
Vol 9 ◽  
Author(s):  
Yao Jiang ◽  
Quan Zou ◽  
Bo Liu ◽  
Shujuan Li ◽  
Yi Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hair Follicle ◽  
Human Hair ◽  
Scalp Hair ◽  
Expression Patterns ◽  
Marker Gene ◽  
Morphological Observation ◽  
Suitable Model ◽  
Type I ◽  
Marker Gene Expression

The pig is an increasingly popular biomedical model, but only a few in depth data exist on its studies in hair follicle (HF) morphogenesis and development. Hence, the objective of this study was to identify the suitability of the pig as an animal model for human hair research. We performed a classification of pig HF morphogenesis stages and hair types. All four different hair types sampled from 17 different body parts in pig were similar to those of human. The Guard_2 sub-type was more similar to type II human scalp hair while Guard_1, Awl, Auchene, and Zigzag were similar to type I scalp hair. Based on morphological observation and marker gene expression of HF at 11 different embryonic days and six postnatal days, we classified pig HF morphogenesis development from E41 to P45 into three main periods – induction (E37–E41), organogenesis (E41–E85), and cytodifferentiation (&gt;E85). Furthermore, we demonstrated that human and pig share high similarities in HF morphogenesis occurrence time (early/mid gestational) and marker gene expression patterns. Our findings will facilitate the study of human follicle morphogenesis and research on complex hair diseases and offer researchers a suitable model for human hair research.

scholarly journals MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway

2014 ◽  
Vol 207 (4) ◽  
pp. 549-567 ◽  
Author(s):  
Mohammed I. Ahmed ◽  
Majid Alam ◽  
Vladimir U. Emelianov ◽  
Krzysztof Poterlowicz ◽  
Ankit Patel ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Hair Follicle ◽  
Wnt Pathway ◽  
Expression Patterns ◽  
Gene Activation ◽  
Wnt Signaling Pathway ◽  
Skin Development ◽  
Cell Functions ◽  
Skin Morphogenesis ◽  
Hair Follicle Development

Skin development is governed by complex programs of gene activation and silencing, including microRNA-dependent modulation of gene expression. Here, we show that miR-214 regulates skin morphogenesis and hair follicle (HF) cycling by targeting β-catenin, a key component of the Wnt signaling pathway. miR-214 exhibits differential expression patterns in the skin epithelium, and its inducible overexpression in keratinocytes inhibited proliferation, which resulted in formation of fewer HFs with decreased hair bulb size and thinner hair production. The inhibitory effects of miR-214 on HF development and cycling were associated with altered activities of multiple signaling pathways, including decreased expression of key Wnt signaling mediators β-catenin and Lef-1, and were rescued by treatment with pharmacological Wnt activators. Finally, we identify β-catenin as one of the conserved miR-214 targets in keratinocytes. These data provide an important foundation for further analyses of miR-214 as a key regulator of Wnt pathway activity and stem cell functions during normal tissue homeostasis, regeneration, and aging.

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