Therapeutic success of sodium thiosulfate in treating cutaneous calciphylaxis in a patient with hyperphosphataemic familial tumoral calcinosis

2021 ◽  
Author(s):  
Sheila Requena ◽  
Jorge Santos‐Juanes ◽  
Patricia Morales ◽  
Carlos Gómez
Keyword(s):  
Sodium Thiosulfate ◽  
Tumoral Calcinosis ◽  
Therapeutic Success

Efficacy of intralesional sodium thiosulfate injections for disabling tumoral calcinosis: Two cases

2017 ◽  
Vol 47 (3) ◽  
pp. 451-455 ◽  
Author(s):  
J. Goossens ◽  
M. Courbebaisse ◽  
E. Caudron ◽  
C. Bahans ◽  
V. Vacquerie ◽  
...  
Keyword(s):  
Sodium Thiosulfate ◽  
Tumoral Calcinosis

The Use of Sodium Thiosulfate in the Treatment of Familial Tumoral Calcinosis: A Novel Application

2011 ◽  
pp. OR44-3-OR44-3
Author(s):  
Naga M Yalla ◽  
Hanna Mawad
Keyword(s):  
Sodium Thiosulfate ◽  
Tumoral Calcinosis

Sodium Thiosulfate Treatment of Tumoral Calcinosis in Patients with End-Stage Renal Disease

Renal Failure ◽  
1990 ◽  
Vol 12 (4) ◽  
pp. 213-219 ◽  
Author(s):  
G. Kyriakopoulos ◽  
K. Kontogianni
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Sodium Thiosulfate ◽  
Tumoral Calcinosis ◽  
Stage Renal Disease ◽  
End Stage

Intravenous sodium thiosulfate for treating tumoral calcinosis associated with systemic disorders: Report of four cases

2017 ◽  
Vol 84 (3) ◽  
pp. 341-344 ◽  
Author(s):  
Arthur Mageau ◽  
Vincent Guigonis ◽  
Voa Ratzimbasafy ◽  
Thomas Bardin ◽  
Pascal Richette ◽  
...  
Keyword(s):  
Sodium Thiosulfate ◽  
Tumoral Calcinosis ◽  
Intravenous Sodium

scholarly journals Topical Sodium Thiosulfate: A Treatment for Calcifications in Hyperphosphatemic Familial Tumoral Calcinosis?

2016 ◽  
Vol 101 (7) ◽  
pp. 2810-2815 ◽  
Author(s):  
Jérémy Jost ◽  
Claire Bahans ◽  
Marie Courbebaisse ◽  
Tu-Anh Tran ◽  
Agnès Linglart ◽  
...  
Keyword(s):  
Sodium Thiosulfate ◽  
Tumoral Calcinosis ◽  
Hyperphosphatemic Familial Tumoral Calcinosis

Intravenous sodium thiosulfate combined with parathyroidectomy as a cure for uremic tumoral calcinosis in a hemodialysis patient

2020 ◽  
pp. 105043
Author(s):  
Jiali Li ◽  
Mingming Yan ◽  
Lu Ren ◽  
Hong Deng ◽  
Rui Wen
Keyword(s):  
Hemodialysis Patient ◽  
Sodium Thiosulfate ◽  
Tumoral Calcinosis ◽  
Intravenous Sodium

Treatment of Uremic Tumoral Calcinosis in Maintenance Hemodialysis Patients

2020 ◽  
Vol 49 (6) ◽  
pp. 658-664 ◽  
Author(s):  
Guibao Ke ◽  
Sijia Li ◽  
Yanhai Cui ◽  
Xueqin  Chen ◽  
Huimin  Che ◽  
...  
Keyword(s):  
Treatment Group ◽  
Drug Treatment ◽  
Clinical Symptoms ◽  
Sodium Thiosulfate ◽  
Tumoral Calcinosis ◽  
Maintenance Hemodialysis ◽  
Limited Data ◽  
Metastatic Tissue ◽  
Drug Treatment Group

<b><i>Background/Aims:</i></b> Uremic tumoral calcinosis (UTC) is a rare disease with metastatic tissue calcification in maintenance hemodialysis (HD) patients. However, limited data are available on the treatment of UTC in HD patients. This article mainly discusses the diagnostic findings and efficacy of treatment on HD patients with UTC. <b><i>Methods:</i></b> A retrospective analysis was conducted based on the data of 13 cases of UTC, including their clinical features, biochemical indicators, imaging findings, diagnosis, therapeutic methods, and follow-up results. Parathyroidectomy (PTX) or drug treatment was determined based on intact parathyroid hormone (iPTH) levels and clinical symptoms. <b><i>Results:</i></b> All 13 patients were diagnosed as UTC definitely by imaging examination. The predominant areas involved were the buttocks (4 cases, 30.77%), shoulders (4 cases, 30.77%), and elbows (3 cases, 23.08%). Based on the levels of iPTH, cases were categorized into 2 different groups: PTX treatment group was associated with high levels of iPTH, while drug treatment group (lanthanum carbonate or sevelamer with sodium thiosulfate) was associated with lower iPTH levels. After PTX treatment, there was a significant decrease in serum iPTH, calcium (Ca), phosphate (P), and alkaline phosphatase levels (<i>p</i> &#x3c; 0.05). In drug treatment group, the serum <i>p</i> levels were decreased significantly, along with a finding that hemoglobin levels were increased (<i>p</i> &#x3c; 0.05). All the UTC had lessened or even disappeared after 4–6 months treatment. <b><i>Conclusions:</i></b> Although most UTC patients have an increased iPTH, a small number had lower iPTH levels. Based on iPTH levels and clinical symptoms, the patients were treated with PTX or drug therapy. With proper treatment, UTC disappeared without the need for surgery to remove calcinosis tissue.

scholarly journals AB0882 Efficacy of intralesionnal sodium thiosulfate in disabling tumoral calcinosis: about two cases

2017 ◽  
Author(s):  
J Goossens ◽  
M Courbebaisse ◽  
V Ratsimbazafy ◽  
D Bazin ◽  
M Daudon ◽  
...  
Keyword(s):  
Sodium Thiosulfate ◽  
Tumoral Calcinosis

Familial hyperphosphatemic tumoral calcinosis in an unusual and usual sites and dramatic improvement with the treatment of acetazolamide, sevelamer and topical sodium thiosulfate

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Merve Emecen Sanli ◽  
Ayse Kilic ◽  
Ekin Aktasoglu ◽  
Asli Inci ◽  
Ilyas Okur ◽  
...  
Keyword(s):  
Female Patient ◽  
Combination Treatment ◽  
Treatment Strategy ◽  
Sodium Thiosulfate ◽  
Treatment Strategies ◽  
Tumoral Calcinosis ◽  
Controlled Trials ◽  
Dramatic Improvement ◽  
Case Presentation ◽  
Novel Treatment

Abstract Objectives Familial hyperphosphatemic tumoral calcinosis is a rare disorder characterized by hyperphosphatemia with recurrent ectopic periarticular calcifications, in addition to other visceral and vascular manifestations, without any inflammatory or neoplastic disorder. The available treatment strategies are limited. Here we report an eight year old female patient with recurrent lesions under the chin, and bilateral hips which are painful and improving of the size of the lesions and hyperphosphatemia. Case presentation The patient was started to the treatment with peroral acetazolamide however the lesion did not regress but a new lesion appeared then we added sevelamer and topical sodium thiosulfate treatment for three months. After the three months of the combination treatment the lesions, there were no pain, no hyperphospahtemia regression/disappearance of the lesions. Conclusions This combination treatment or topical sodium thiosulfate use only may be a novel treatment strategy for the patients prospective controlled trials are needed.

Detection of atrial natriuretic peptides (ANP) in rat atria by immunogold-silver staining (IGSS)

1994 ◽  
Vol 52 ◽  
pp. 304-305
Author(s):  
Robyn Rufner ◽  
Gerhard W. Hacker ◽  
Michele Forte ◽  
Nancyleigh E. Carson ◽  
Cristina Xenachis ◽  
...  
Keyword(s):  
Natriuretic Peptides ◽  
Silver Staining ◽  
Sodium Thiosulfate ◽  
Atrial Natriuretic Peptides ◽  
Paraffin Sections ◽  
Glass Slides ◽  
Metallic Salts ◽  
Wistar Kyoto ◽  
Right Atria

The use of immunogold-silver staining (IGSS) to enhance label penetration and Localization for immunocytochemistry or in situ hybridization utilizing a variety of metallic salts has been documented. In this morphological study, the effects of silver acetate, silver lactate and silver nitrate were evaluated for immunogold-labeling of a trial natriuretic peptides (ANP) in rat right atria.Eight Wistar Kyoto retired breeders were sedated with pentobarbital, perfused with either 4% paraformaldehyde (LM) or Karnovsky's fixative (EM), and right atria were dissected, processed, embedded in paraffin or epon, respectively and sectioned according to conventional methods. For light microscopy, an indirect IGSS method according to Hacker (3) was performed. Paraffin sections on glass slides were washed in ddH2O, immersed in Lugol's iodine, washed in ddH2O and treated with 2.5% aqueous sodium thiosulfate for 20 sec. After additional washes in ddH2O and TBS-0.1% fish gelatin, 10% normal goat serum (PBS with 1% BSA) was applied for 20 min before an overnight incubation at 4°C with a polyclonal α-ANP primary antibody (Peninsula Labs, 1:1000 in TBS/BSA).

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