Inpatient COVID‐19 Outcomes in Solid Organ Transplant Recipients Compared to Non‐Solid Organ Transplant Patients: A Retrospective Cohort

Aim: To determine overall mortality, outcome and mortality of COVID 19 infection in solid organ transplant pts. Study design: Retrospective study. Place and duration of study: Department of Medicine, Bahria International Hospital, Lahore, Pakistan15thApril 2020 to 31stDecember 2020. Methodology: Twenty-three patients 18 out of which were kidney transplant recipients while 5 were liver transplant recipients. All the solid organ transplant patients who were admitted with Sars CoV2 (Corona virus) infection were recorded. Their charts were reviewed regarding clinical course, management, and outcome of COVID-19 infection in recipients of solid organ (liver and kidney) transplant. Results: Mean age was 44.8±10.9 years. Median time lapsed from transplant surgery to admission was 2.88 years (interquartile range 2.25, 7.33). Median hospital stay was 15 days (interquartile range 13, 28). All 23 patients were admitted and managed, with 17 (73.91%) admitted in ICU. Over half of the cases (58.2%) presented with raised serum creatinine due to acute kidney injury. 80% received azithromycin, Tocilizumab and 50% received Remdesivir.Antimetabolites with or without calcineurin inhibitors were held or reduced. A total of 5 patients had died while the others 18 patients (78.26%) were discharged home. Conclusion: There is a theoretical high risk of getting Sars CoV-2 infection in post-transplant patients but we did not find any increase in overall mortality in solid organ transplant recipients receiving immunosuppressive therapy who acquired Sars CoV2 infection as compared with mortality in the general patients with SARS-CoV-2. We had favorable outcome in solid organ transplant COVID 19 patients in our center. Keywords: Incidence, Outcome, COVID-19, Infection

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Thrombocytopenia Associated with Linezolid Therapy in Solid Organ Transplant Recipients: A Retrospective Cohort Study

Surgical Infections ◽

10.1089/sur.2013.190 ◽

2015 ◽

Vol 16 (4) ◽

pp. 361-367 ◽

Cited By ~ 6

Author(s):

Jeffrey M. Tessier ◽

Thaddeus Puzio ◽

Andrew Young ◽

Luke Wolfe ◽

Jinfeng Han ◽

...

Keyword(s):

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Organ Transplant ◽

Solid Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Organ Transplant Recipients ◽

Linezolid Therapy ◽

Solid Organ Transplant Recipients

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Outcomes of human adenovirus infection and disease in a retrospective cohort of pediatric solid organ transplant recipients

Pediatric Transplantation ◽

10.1111/petr.13510 ◽

2019 ◽

Vol 23 (6) ◽

Cited By ~ 3

Author(s):

Craig L. K. Boge ◽

Brian T. Fisher ◽

Hans Petersen ◽

Alix E. Seif ◽

Dale R. Purdy ◽

...

Keyword(s):

Retrospective Cohort ◽

Organ Transplant ◽

Human Adenovirus ◽

Solid Organ Transplant ◽

Solid Organ ◽

Adenovirus Infection ◽

Transplant Recipients ◽

Organ Transplant Recipients ◽

Solid Organ Transplant Recipients

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Rhinosinusitis in Solid Organ Transplant Recipients: Analysis of 4562 Transplanted Patients

American Journal of Rhinology and Allergy ◽

10.1177/1945892418808717 ◽

2018 ◽

Vol 33 (1) ◽

pp. 56-61 ◽

Cited By ~ 2

Author(s):

Sharon Tzelnick ◽

Ethan Soudry

Keyword(s):

Survival Rates ◽

Organ Transplant ◽

Solid Organ Transplant ◽

Sinus Surgery ◽

Solid Organ ◽

Transplant Recipients ◽

Organ Transplant Recipients ◽

Transplant Patients ◽

Solid Organ Transplant Recipients ◽

Lung Transplant Recipients

Introduction Survival rates of solid organ transplant recipients are steadily increasing. Chronic immunosuppression is a key to sustain the transplanted organ. Thus, these patients are at a higher risk for fulminant disease and severe complications of rhinosinusitis (RS). Surprisingly, this has been scarcely discussed in the literature. Objective To analyze the characteristics and disease course of RS in solid organ transplant recipients. Materials and Methods Retrospective study. Medical records of all solid organ transplant recipients with a diagnosis RS treated at a national transplant center between the years 2001 and 2016 were reviewed. Results Of 4562 solid organ transplant recipients, a documented diagnosis of RS was identified only in 61 (1.3%) patients. Sixty-four patients presented with posttransplantation RS; of them, 54.5% had chronic RS (CRS) and the remaining 45.5% patients were diagnosed with acute RS. Microbial cultures grew almost exclusively bacterial pathogens. A documented invasive fungal infection was noted in only 2 patients. A total of 24 (40%) patients underwent endoscopic sinus surgery, the majority (22) for CRS. On subgroup analysis, surgical intervention was more frequent in lung transplant recipients ( P = .005). Neither specific disease nor surgical complications were found. Conclusions Interestingly, acute fulminant infection or sinusitis complications in solid organ transplant patients were much lower than expected. CRS in this patient group was less frequent than expected as well. Whether chronic immunosuppression minimizes the likelihood for CRS deserves further investigation. A more surgically oriented approach in CRS patients may be favored early in the management course of medically refractory patients in light of patients excellent outcomes.

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Predicting factors leading to cardiac arrest in solid organ transplant recipients: a retrospective analysis of code blue patients

Journal of Chitwan Medical College ◽

10.3126/jcmc.v8i1.23721 ◽

2018 ◽

Vol 8 (1) ◽

pp. 62-67

Author(s):

Subhash P. Acharya ◽

Laura Hawryluck ◽

Stuart McCluskey ◽

Andrew Steel

Keyword(s):

Serum Magnesium ◽

Organ Transplant ◽

Solid Organ Transplant ◽

Warning Signs ◽

Solid Organ ◽

Transplant Recipients ◽

Organ Transplant Recipients ◽

Transplant Patients ◽

Code Blue ◽

Solid Organ Transplant Recipients

Background: Cardio Pulmonary (Code Blue) arrests in solid organ transplant recipients are particularly distressing events in view of the tremendous investment by organ donors, families, and by the healthcare system. Methods: After ethical approval, all code blue events occurring in solid organ transplant patients were identified from Critical Care Response Team (CCRT) database and the code blue resuscitation records from 2007-2011. All patients who sustained cardio-respiratory arrests were included. Resuscitation records were also explored to identify quality, duration and immediate event and outcome. Results: Over the five-year period, there were 63 code blue calls in solid organ transplant patients out of which only 27 (n=27) were actual code blue arrest requiring resuscitation. The frequency was highest in liver transplant (10), followed by lungs (8), kidney (5), double organ (kidney + liver/lung = 2), and heart (1), and one patient with Liver transplantation had arrested twice. Seventeen (62.96%) of these patients were in the ward while 10 (37.04%) were in the step-down unit (SDU) when the arrest occurred. Most of them (16, 59.25%) were attended by a nurse within 30-mins prior to the code. Factors associated in these code blue patients were documented source of infection (11, 40.74%), blood transfusion (7, 23.9%), surgical event as cause of arrest (6, 22.22%), procedures within 24 hours (6, 22.22%) and dialysis within 24 hours (5, 18.51%). It was also found that serum magnesium was low on almost all patients. Conclusion: Even though the frequency of code blue events in solid organ transplant patients was not high, it was concerning that in many events with prior warning signs of deterioration did not result in CCRT being called. However resuscitations were prolonged reflecting the teams’ investment in this patient population. This study thus highlights the importance of early involvement of CCRT in these patients.

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