Long‐term incidence of dysplasia and colorectal cancer in an ulcerative colitis population‐based cohort

2020 ◽  
Vol 90 (5) ◽  
pp. 821-825
Author(s):  
Isaac Tranter‐Entwistle ◽  
Tamara G. Mullaney ◽  
Kimberley Noah ◽  
John Pearson ◽  
James Falvey ◽  
...  
2021 ◽  
Author(s):  
Milad Fahim ◽  
Lea M. Dijksman ◽  
Thijs A. Burghgraef ◽  
Paul B. van der Nat ◽  
Wouter J.M. Derksen ◽  
...  

2021 ◽  
Author(s):  
Grace Gatenby ◽  
Tamara Glyn ◽  
John Pearson ◽  
Richard Gearry ◽  
Timothy Eglinton

2011 ◽  
Vol 140 (5) ◽  
pp. S-770 ◽  
Author(s):  
Rahim Kachra ◽  
Murad Bandali ◽  
Marie-Claude Proulx ◽  
Allen Lim ◽  
James N. Hubbard ◽  
...  

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S271-S271
Author(s):  
J M Cha ◽  
S H Park ◽  
K H Rhee ◽  
S N Hong ◽  
Y H Kim ◽  
...  

Abstract Background No population-based study has evaluated the natural course of ulcerative colitis (UC) over three decades in non-Caucasians. We aimed to assess the long-term natural course of Korean patients with UC in a population-based cohort. Methods This Korean population-based SK-IBD cohort included all patients (N = 1013) newly diagnosed with UC during 1986–2015. Disease outcomes and their predictors were evaluated. Results During the median follow-up of 105 months, the overall use of systemic corticosteroids, thiopurines, and anti-tumour necrosis factor (TNF) agents was 40.8%, 13.9%, and 6.5%, respectively. Over time, the cumulative risk of commencing corticosteroids decreased, whereas that of commencing thiopurines and anti-TNF agents increased. During follow-up, 28.7% of 778 patients with proctitis or left-sided colitis at diagnosis experienced proximal disease extension. A total of 28 patients (2.8%) underwent colectomy, demonstrating cumulative risks of colectomy at 1, 5, 10, 20, and 30 years after diagnosis of 1.0%, 1.9%, 2.2%, 5.1%, and 6.4%, respectively. Multivariate Cox regression analysis revealed that extensive colitis at diagnosis (hazard ratio [HR] 8.249, 95% confidence interval [CI] 2.394–28.430), ever use of corticosteroids (HR 6.437, 95% CI 1.440–28.773), and diagnosis in the anti-TNF era (HR 0.224, 95% CI 0.057–0.886) were independent predictors of colectomy. The standardised mortality ratio in UC patients was 0.725 (95% CI 0.508–1.004). Conclusion Korean UC patients may have a better clinical course than Western patients, as indicated by a lower colectomy rate. The overall colectomy rate has continued to decrease over the past three decades.


2014 ◽  
Vol 46 (4) ◽  
pp. 376-382 ◽  
Author(s):  
Isabelle Fournel ◽  
Vanessa Cottet ◽  
Christine Binquet ◽  
Valérie Jooste ◽  
Jean Faivre ◽  
...  

2020 ◽  
Vol 13 (7) ◽  
pp. 611-622
Author(s):  
Ruth Elisa Eyl ◽  
Lena Koch-Gallenkamp ◽  
Lina Jansen ◽  
Viola Walter ◽  
Prudence R. Carr ◽  
...  

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ruth Elisa Eyl ◽  
Melissa S. Y. Thong ◽  
Prudence R. Carr ◽  
Lina Jansen ◽  
Lena Koch-Gallenkamp ◽  
...  

2016 ◽  
Vol 32 (8) ◽  
pp. 1367-1374
Author(s):  
Jinma Ren ◽  
Carmen S. Kirkness ◽  
Minchul Kim ◽  
Carl V. Asche ◽  
Srinivas Puli

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