Reparative effect of super active platelet lysate combined with allogeneic bone for large bone defects

2021 ◽  
Author(s):  
Qinglong Wang ◽  
Zhipeng Huang ◽  
Xi Huang ◽  
Tao Zhang ◽  
Wenbo Wang
Keyword(s):  
Bone Defects ◽  
Platelet Lysate ◽  
Allogeneic Bone ◽  
Reparative Effect ◽  
Large Bone ◽  
Large Bone Defects

Use of Adipose Derived Stem Cells to Treat Large Bone Defects. Addendum

2009 ◽  
Author(s):  
Barbara D. Boyan ◽  
Robert E. Gulderg
Keyword(s):  
Stem Cells ◽  
Bone Defects ◽  
Adipose Derived Stem Cells ◽  
Large Bone ◽  
Large Bone Defects

scholarly journals Factors related to large bone defects of bipolar lesions and a high number of instability episodes with anterior glenohumeral instability

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Noboru Matsumura ◽  
Kazuya Kaneda ◽  
Satoshi Oki ◽  
Hiroo Kimura ◽  
Taku Suzuki ◽  
...  
Keyword(s):  
Humeral Head ◽  
Glenohumeral Joint ◽  
Three Dimensional ◽  
Clinical Results ◽  
Bone Defects ◽  
Symptom Duration ◽  
Glenohumeral Instability ◽  
Explanatory Variables ◽  
Large Bone ◽  
Large Bone Defects

Abstract Background Significant bone defects are associated with poor clinical results after surgical stabilization in cases of glenohumeral instability. Although multiple factors are thought to adversely affect enlargement of bipolar bone loss and increased shoulder instability, these factors have not been sufficiently evaluated. The purpose of this study was to identify the factors related to greater bone defects and a higher number of instability episodes in patients with glenohumeral instability. Methods A total of 120 consecutive patients with symptomatic unilateral instability of the glenohumeral joint were retrospectively reviewed. Three-dimensional surface-rendered/registered models of bilateral glenoids and proximal humeri from computed tomography data were matched by software, and the volumes of bone defects identified in the glenoid and humeral head were assessed. After relationships between objective variables and explanatory variables were evaluated using bivariate analyses, factors related to large bone defects in the glenoid and humeral head and a high number of total instability episodes and self-irreducible dislocations greater than the respective 75th percentiles were evaluated using logistic regression analyses with significant variables on bivariate analyses. Results Larger humeral head defects (P < .001) and a higher number of total instability episodes (P = .032) were found to be factors related to large glenoid defects. On the other hand, male sex (P = .014), larger glenoid defects (P = .015), and larger number of self-irreducible dislocations (P = .027) were related to large humeral head bone defects. An increased number of total instability episodes was related to longer symptom duration (P = .001) and larger glenoid defects (P = .002), and an increased number of self-irreducible dislocations was related to larger humeral head defects (P = .007). Conclusions Whereas this study showed that bipolar lesions affect the amount of bone defects reciprocally, factors related to greater bone defects differed between the glenoid and the humeral head. Glenoid defects were related to the number of total instability episodes, whereas humeral head defects were related to the number of self-irreducible dislocations.

scholarly journals Vascularization of Nanohydroxyapatite/Collagen/Poly(L-lactic acid) Composites by Implanting Intramuscularly In Vivo

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Hai Wang ◽  
Xiao Chang ◽  
Guixing Qiu ◽  
Fuzhai Cui ◽  
Xisheng Weng ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Orthopaedic Surgery ◽  
Bone Substitutes ◽  
Bone Defects ◽  
Large Defect ◽  
Natural Bone ◽  
Composition And Structure ◽  
Large Bone ◽  
Large Bone Defects

It still remains a major challenge to repair large bone defects in the orthopaedic surgery. In previous studies, a nanohydroxyapatite/collagen/poly(L-lactic acid) (nHAC/PLA) composite, similar to natural bone in both composition and structure, has been prepared. It could repair small sized bone defects, but they were restricted to repair a large defect due to the lack of oxygen and nutrition supply for cell survival without vascularization. The aim of the present study was to investigate whether nHAC/PLA composites could be vascularized in vivo. Composites were implanted intramuscularly in the groins of rabbits for 2, 6, or 10 weeks (n=5×3). After removing, the macroscopic results showed that there were lots of rich blood supply tissues embracing the composites, and the volumes of tissue were increasing as time goes on. In microscopic views, blood vessels and vascular sprouts could be observed, and microvessel density (MVD) of the composites trended to increase over time. It suggested that nHAC/PLA composites could be well vascularized by implanting in vivo. In the future, it would be possible to generate vascular pedicle bone substitutes with nHAC/PLA composites for grafting.

scholarly journals The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and clinical evidence

BMC Medicine ◽  
2012 ◽  
Vol 10 (1) ◽  
Author(s):  
Rozalia Dimitriou ◽  
George I Mataliotakis ◽  
Giorgio Maria Calori ◽  
Peter V Giannoudis
Keyword(s):  
Bone Regeneration ◽  
Clinical Evidence ◽  
Bone Defects ◽  
Guided Bone Regeneration ◽  
Barrier Membranes ◽  
Large Bone ◽  
Large Bone Defects

scholarly journals Tissue engineered vascularized periosteal flap enriched with MSC/EPCs for the treatment of large bone defects in rats

2017 ◽  
Vol 39 (4) ◽  
pp. 907-917 ◽  
Author(s):  
Christoph Nau ◽  
Dirk Henrich ◽  
Caroline Seebach ◽  
Katrin Schröder ◽  
John H. Barker ◽  
...  
Keyword(s):  
Bone Defects ◽  
Periosteal Flap ◽  
Large Bone ◽  
Large Bone Defects

Reconstruction of Large Bone Defects Using induced membrane Technique of Masquelet

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Mohammed soliman ◽  
Yousif Khira ◽  
.mohamed Elzoheiry ◽  
ahmad abdelwahab
Keyword(s):  
Bone Defects ◽  
Induced Membrane ◽  
Membrane Technique ◽  
Induced Membrane Technique ◽  
Large Bone ◽  
Large Bone Defects

Composite Scaffolds for Large Bone Defects

2019 ◽  
pp. 250-257
Author(s):  
Evangelos Daskalakis ◽  
Enes Aslan ◽  
Fengyuan Liu ◽  
Glen Cooper ◽  
Andrew Weightman ◽  
...  
Keyword(s):  
Bone Defects ◽  
Composite Scaffolds ◽  
Large Bone ◽  
Large Bone Defects

Modeling and Simulation of a Novel Functional Brace for Large Bone Defects

2019 ◽  
pp. 155-161
Author(s):  
Mohammed S. Alqahtani ◽  
Abdalla M. Omar ◽  
Glen Cooper ◽  
P. J. Bartolo
Keyword(s):  
Modeling And Simulation ◽  
Bone Defects ◽  
Functional Brace ◽  
Large Bone ◽  
Large Bone Defects

scholarly journals Bioactive glass can potentially reinforce large bone defects

2016 ◽  
Vol 4 ◽  
Author(s):  
Van Gestel Nicole ◽  
Hulsen Dennis ◽  
Arts Jacobus ◽  
Geurts Jan ◽  
Ito Keita ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Defects ◽  
Large Bone ◽  
Large Bone Defects

scholarly journals Treatment possibilities of jaws bone defects: A case report

2010 ◽  
Vol 57 (1) ◽  
pp. 49-53
Author(s):  
Nenad Tanaskovic ◽  
Sinisa Ristic ◽  
Miroslav Lucic
Keyword(s):  
Bone Regeneration ◽  
Bone Destruction ◽  
Bone Defects ◽  
Significant Loss ◽  
Bone Augmentation ◽  
Surrounding Soft Tissue ◽  
Prosthetic Reconstruction ◽  
Previous Trauma ◽  
Large Bone ◽  
Large Bone Defects

Large bone defects in the jaws can occur as a result of previous trauma, tumor or bone destruction caused by infection. Significant loss of bone volume also may be caused by premature loss of teeth, application of inadequate extraction technique, periodontitis or trauma caused by incorrect prosthetic reconstruction. Very few of these defects are treated using materials for bone augmentation or regeneration in order to preserve the total volume of bone. Depending on the size of a defect, spontaneous bone regeneration of untreated defects is limited by proliferation of surrounding soft tissue. Bone replacement by connective tissue leads to loss of stability, reduces function and disturbs anatomical form of the jaws. The aim of the study was to present a case from clinical praxis which demonstrates bone regeneration provided by bone substitute or its combination with bone grafts.

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