scholarly journals Iatrogenic immunosuppression and risk of non-Hodgkin lymphoma in solid organ transplantation: A population-based cohort study in Australia

2016 ◽  
Vol 174 (4) ◽  
pp. 550-562 ◽  
Author(s):  
Renhua Na ◽  
Maarit A. Laaksonen ◽  
Andrew E. Grulich ◽  
Nicola S. Meagher ◽  
Geoffrey W. McCaughan ◽  
...  
2018 ◽  
Vol 19 (2) ◽  
pp. 522-531 ◽  
Author(s):  
An-Wen Chan ◽  
Kinwah Fung ◽  
Peter C. Austin ◽  
S. Joseph Kim ◽  
Lianne G. Singer ◽  
...  

2012 ◽  
Vol 56 (11) ◽  
pp. 6041-6043 ◽  
Author(s):  
Tark Kim ◽  
Heungsup Sung ◽  
Yu-Mi Lee ◽  
Hyo-Lim Hong ◽  
Sung-Han Kim ◽  
...  

ABSTRACTThere are no data on the efficacy of secondary prophylaxis againstPneumocystispneumonia after solid organ transplantation. Therefore, we investigated the rate of recurrence ofPneumocystispneumonia after solid organ transplantation in a retrospective cohort study. Between 2005 and 2011, a total of 41 recipients recovered fromPneumocystispneumonia. Of these, 22 (53.7%) received secondary prophylaxis. None of the 41 recipients experienced recurrence ofPneumocystispneumonia during the follow-up, regardless of secondary prophylaxis.


2013 ◽  
Vol 16 (1) ◽  
pp. 26-36 ◽  
Author(s):  
E. Bucheli ◽  
G. Kralidis ◽  
K. Boggian ◽  
A. Cusini ◽  
C. Garzoni ◽  
...  

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S75-S76 ◽  
Author(s):  
Ige George ◽  
Carlos Santos

Abstract Background Coccidioidomycosis is an invasive fungal infection in solid organ transplantation (SOT) recipients with an incidence of 1.4–6.9% in endemic regions. There are no population-level data describing the incidence and outcomes of coccidioidomycosis in SOT recipients. Methods We assembled a large cohort of adult SOT recipients using ICD-9-CM billing data from the California State Inpatient Databases from 2004 to 2011. Demographics, comorbidities, coccidioidomycosis coded during hospitalization and inpatient death were identified. We used Cox proportional hazard multivariate analyses to identify risk factors for coccidioidomycosis and death. Results 20,602 SOT recipients were identified during the study period (median follow-up time = 1507 days). Eighty-seven patients (0.42%) with coccidioidomycosis were identified of whom 17 (20%) were coded with progressive/disseminated disease. Median time to diagnosis was 164 days (IQR 16–844) from transplantation. Fifty-one of 87 (58%) of these infections were diagnosed within the first year posttransplant and 29/87 (33.3%) were identified within the first month. Twenty-one of 87 (24%) of patients with coccidioidomycosis died compared with 1928/18587 (9.4%) of patients without coccidioidomycosis (P < 0.001). Coccidioidomycosis was independently associated with death (HR, 3.1; 95% CI, 2.0–4.4), after adjusting for age, type of transplantation, transplant failure/rejection, and other comorbidities (Table) (Figure). Conclusion Coccidioidomycosis resulting in hospitalization is rare in an endemic region in the current era of screening and prophylactic antifungal therapy. Preventing infection in solid organ transplant recipients is imperative because overall mortality remains high. Disclosures All authors: No reported disclosures.


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