Glycogen synthase kinase 3β/CCR6‐positive bone marrow cells correlate with disease activity in multicentric Castleman disease‐TAFRO

2021 ◽  
Author(s):  
Nobuya Abe ◽  
Michihito Kono ◽  
Michihiro Kono ◽  
Naoki Ohnishi ◽  
Tomoya Sato ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Disease Activity ◽  
Bone Marrow Cells ◽  
Glycogen Synthase ◽  
Castleman Disease ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Multicentric Castleman Disease ◽  
Marrow Cells

scholarly journals Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells

2017 ◽  
Vol 8 (6) ◽  
pp. e2902-e2902 ◽  
Author(s):  
Rafik Mansouri ◽  
Yohann Jouan ◽  
Eric Hay ◽  
Claudine Blin-Wakkach ◽  
Monique Frain ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Transgenic Mice ◽  
Heparan Sulfate ◽  
Bone Marrow Cells ◽  
Glycogen Synthase ◽  
Osteoblastic Differentiation ◽  
Bone Surface ◽  
Osteoblast Activity ◽  
Marrow Cells

Abstract Stimulating bone formation is an important challenge for bone anabolism in osteoporotic patients or to repair bone defects. The osteogenic properties of matrix glycosaminoglycans (GAGs) have been explored; however, the functions of GAGs at the surface of bone-forming cells are less documented. Syndecan-2 is a membrane heparan sulfate proteoglycan that is associated with osteoblastic differentiation. We used a transgenic mouse model with high syndecan-2 expression in osteoblasts to enrich the bone surface with cellular GAGs. Bone mass was increased in these transgenic mice. Syndecan-2 overexpression reduced the expression of receptor activator of NF-kB ligand (RANKL) in bone marrow cells and strongly inhibited bone resorption. Osteoblast activity was not modified in the transgenic mice, but bone formation was decreased in 4-month-old transgenic mice because of reduced osteoblast number. Increased proteoglycan expression at the bone surface resulted in decreased osteoblastic and osteoclastic precursors in bone marrow. Indeed, syndecan-2 overexpression increased apoptosis of mesenchymal precursors within the bone marrow. However, syndecan-2 specifically promoted the vasculature characterized by high expression of CD31 and Endomucin in 6-week-old transgenic mice, but this was reduced in 12-week-old transgenic mice. Finally, syndecan-2 functions as an inhibitor of Wnt-β-catenin–T-cell factor signaling pathway, activating glycogen synthase kinase 3 and then decreasing the Wnt-dependent production of Wnt ligands and R-spondin. In conclusion, our results show that GAG supply may improve osteogenesis, but also interfere with the crosstalk between the bone surface and marrow cells, altering the supporting function of osteoblasts.

CABG and intramyocardial delivery of CD133+ bone marrow cells: 3-years follow-up on safety and efficacy

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
C Stamm ◽  
YH Choi ◽  
A Liebold ◽  
HD Kleine ◽  
S Dunkelmann ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Safety And Efficacy ◽  
Intramyocardial Delivery ◽  
Marrow Cells

Transplantation of culture-expanded bone marrow cells and platelet rich plasma in lower limb lengthening for short stature patients

2015 ◽  
Author(s):  
Hiroshi Kitoh ◽  
Kenichi Mishima ◽  
Masaki Matsushita ◽  
Naoki Ishiguro
Keyword(s):  
Bone Marrow ◽  
Short Stature ◽  
Lower Limb ◽  
Bone Marrow Cells ◽  
Platelet Rich Plasma ◽  
Limb Lengthening ◽  
Marrow Cells

Influence of the drug of sodium diclofenac in a dose dl100 and dl50 on mechanisms of differentiation of cells of red bone marrow cells of rats in vitro

2020 ◽  
Vol 2020 (1) ◽  
pp. 56-61 ◽  
Author(s):  
A. S. Ivanov ◽  
◽  
S. O. Kondratov ◽  
S. I. Skljar ◽  
G. V. Zapko ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Red Bone Marrow ◽  
Sodium Diclofenac ◽  
Marrow Cells

Receptors for recombinant erythropoietin in human bone marrow cells

1987 ◽  
Vol 47 (8) ◽  
pp. 823-827 ◽  
Author(s):  
K. Rosenlof ◽  
F. Fyhrquist ◽  
F. Pekonen
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Recombinant Erythropoietin ◽  
Marrow Cells
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