Indications for intervention during active surveillance of prostate cancer: a comparison of the Johns Hopkins and Prostate Cancer Research International Active Surveillance (PRIAS) protocols

2014 ◽  
Vol 115 (2) ◽  
pp. 216-222 ◽  
Author(s):  
Max Kates ◽  
Jeffrey J. Tosoian ◽  
Bruce J. Trock ◽  
Zhaoyong Feng ◽  
H. Ballentine Carter ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Research ◽  
Active Surveillance ◽  
Prostate Cancer Research

scholarly journals Complications after prostate biopsies in men on active surveillance and its effects on receiving further biopsies in the Prostate cancer Research International: Active Surveillance (PRIAS) study

2016 ◽  
Vol 118 (3) ◽  
pp. 366-371 ◽  
Author(s):  
Leonard P. Bokhorst ◽  
Inari Lepistö ◽  
Yoshiyuki Kakehi ◽  
Chris H. Bangma ◽  
Tom Pickles ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Research ◽  
Active Surveillance ◽  
Prostate Biopsies ◽  
Prostate Cancer Research

27 Protocol based versus non-protocol based discontinuation in the Prostate cancer Research International: Active Surveillance (PRIAS) study

2014 ◽  
Vol 13 (1) ◽  
pp. e27-e27a
Author(s):  
L.P. Bokhorst ◽  
J.W. Salman ◽  
L.D. Venderbos ◽  
A. Rannikko ◽  
R. Valdagni ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Research ◽  
Active Surveillance ◽  
Prostate Cancer Research

Short-term outcomes of the prospective multicentre ‘Prostate Cancer Research International: Active Surveillance’ study

2010 ◽  
Vol 105 (7) ◽  
pp. 956-962 ◽  
Author(s):  
Roderick C.N. van den Bergh ◽  
Hanna Vasarainen ◽  
Henk G. van der Poel ◽  
Jenneke J. Vis-Maters ◽  
John B. Rietbergen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Research ◽  
Active Surveillance ◽  
Surveillance Study ◽  
Short Term ◽  
Prostate Cancer Research

scholarly journals An assessment of Prostate Cancer Research International: Active Surveillance (PRIAS) criteria for active surveillance of clinically low-risk prostate cancer patients

2017 ◽  
Vol 11 (8) ◽  
pp. 238-43 ◽  
Author(s):  
Vitor Da Silva ◽  
Ilias Cagiannos ◽  
Luke T. Lavallée ◽  
Ranjeeta Mallick ◽  
Kelsey Witiuk ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Research ◽  
Cancer Patients ◽  
Active Surveillance ◽  
Specific Antigen ◽  
Low Risk ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer ◽  
Psa Recurrence ◽  
Prostate Cancer Research

Introduction: Active surveillance is a strategy to delay or prevent treatment of indolent prostate cancer. The Prostate Cancer Research International: Active Surveillance (PRIAS) criteria were developed to select patients for prostate cancer active surveillance. The objective of this study was to compare pathological findings from PRIAS-eligible and PRIAS-ineligible clinically low-risk prostate cancer patients.Methods: A D’Amico low-risk cohort of 1512 radical prostatectomy patients treated at The Ottawa Hospital or Memorial Sloan Kettering Cancer Centre between January 1995 and December 2007 was reviewed. Pathological outcomes (pT3 tumours, Gleason sum ≥7, lymph node metastases, or a composite) and clinical outcomes (prostate-specific antigen [PSA] recurrence, secondary cancer treatments, and death) were compared between PRIAS-eligible and PRIAS-ineligible cohorts.Results: The PRIAS-eligible cohort (n=945) was less likely to have Gleason score ≥7 (odds ratio [OR] 0.61; 95% confidence interval [CI] 0.49‒0.75), pT3 (OR 0.41; 95% CI 0.31‒0.55), nodal metastases (OR 0.37; 95% CI 0.10‒1.31), or any adverse feature (OR 0.56; 95% CI 0.45‒0.69) compared to the PRIAS-ineligible cohort. The probability of any adverse pathology in the PRIAS-eligible cohort was 41% vs. 56% in the PRIAS-ineligible cohort. At median followup of 3.7 years, 72 (4.8%) patients had a PSA recurrence, 24 (1.6%) received pelvic radiation, and 13 (0.9%) received androgen deprivation. No difference was detected for recurrence-free and overall survival between groups (recurrence hazard ratio [HR] 0.71; 95% CI 0.46–1.09 and survival HR 0.72; 95% CI 0.36–1.47).Conclusions: Low-risk prostate cancer patients who met PRIAS eligibility criteria are less likely to have higher-risk cancer compared to those who did not meet at least one of these criteria.

Compliance Rates with the Prostate Cancer Research International Active Surveillance (PRIAS) Protocol and Disease Reclassification in Noncompliers

2015 ◽  
Vol 68 (5) ◽  
pp. 814-821 ◽  
Author(s):  
Leonard P. Bokhorst ◽  
Arnout R. Alberts ◽  
Antti Rannikko ◽  
Riccardo Valdagni ◽  
Tom Pickles ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Research ◽  
Active Surveillance ◽  
Prostate Cancer Research
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