scholarly journals Descriptive Analysis of 179 Reports of Melanoma Originating from Germany Reported as Side Effect to an Adverse Drug Reaction Database and Comparison with Melanoma Cases Contained in German Cancer Registries

2022 ◽  
Author(s):  
Bernhardt Sachs ◽  
Diana Dubrall ◽  
Klaus Kraywinkel ◽  
Maike Schulz ◽  
Matthias Schmid ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Adverse Drug Reaction Database ◽  
Side Effect ◽  
Descriptive Analysis ◽  
Cancer Registries

scholarly journals Adverse Drug Reaction Reports Containing AMR-Relevant MedDRA Terms in the Dutch Pharmacovigilance Database

2021 ◽  
Author(s):  
Jean Marie Vianney Habarugira ◽  
Linda Harmark ◽  
Albert Figueras
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Resistance ◽  
Drug Reaction ◽  
Descriptive Analysis ◽  
Pathogen Resistance ◽  
Pharmacovigilance Centre ◽  
Off Label Use ◽  
Off Label ◽  
Pv Systems ◽  
Pharmacovigilance Database

(1) Background: Antimicrobial resistance (AMR) requires urgent multidisciplinary solutions, and Pharmacovigilance (PV) has the potential to strengthen current antimicrobial stewardship (AMS) strategies. This study aimed to characterise AMR-relevant adverse drug reaction (ADR) reports submitted to The Netherlands Pharmacovigilance Centre (Lareb); (2) Methods: We carried out a descriptive analysis of ADR reports submitted to Lareb, coded with AMR-relevant MedDRA Preferred Terms (PTs).; (3) Results: Between 1998 and Jan 2019, 252 AMR-relevant ADR reports were submitted to Lareb. The most frequent antibiotics were tobramycin (n=89; 35%), colistin (n=30; 11,9%), ciprofloxacin (n=16; 6,35%), doxycycline (n=14; 5,5%) and aztreonam (n=12; 4,76%). The most frequently used PTs were drug ineffective (n=71; 28%), pathogen resistance (n=14; 5%) and drug resistance (n=13; 13%). A total of 119 reports (74%) suggested use-related issues. Watch antibiotics were in 54% of the reports and Reserve antibiotics were in 19%. In the Watch group, “Off label use” and “Product use in unapproved indication” were the most frequent PTs and majority of reports on Reserve antibiotics were coded as “Off label”. (4) Conclusions: Addressing AMR using the PV methods will provide an opportunity for PV expansion and could encourage further investment in both in AMS programs and PV systems.

scholarly journals Mapping endocrine toxicity spectrum of immune checkpoint inhibitors: a disproportionality analysis using the WHO adverse drug reaction database, VigiBase

Endocrine ◽  
2020 ◽  
Vol 69 (3) ◽  
pp. 670-681 ◽  
Author(s):  
Xuefeng Bai ◽  
Xiahong Lin ◽  
Kainan Zheng ◽  
Xiaoyu Chen ◽  
Xiaohong Wu ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Adverse Drug Reaction Database ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Disproportionality Analysis

Drug-Induced Progressive Multifocal Leukoencephalopathy: A Comprehensive Analysis of the WHO Adverse Drug Reaction Database

CNS Drugs ◽  
2015 ◽  
Vol 29 (10) ◽  
pp. 879-891 ◽  
Author(s):  
Mauro Melis ◽  
Chiara Biagi ◽  
Lars Småbrekke ◽  
Francesco Nonino ◽  
Elena Buccellato ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Progressive Multifocal Leukoencephalopathy ◽  
Adverse Drug Reaction Database ◽  
Comprehensive Analysis ◽  
Drug Induced

scholarly journals Identifiability of biologicals: an analysis using the EMA adverse drug reaction database, EudraVigilance

2021 ◽  
Author(s):  
Luis C Pinheiro ◽  
Thijs J Giezen ◽  
Elena Wolff‐Holz ◽  
Martina Weise ◽  
Andrea Laslop ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Adverse Drug Reaction Database
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