scholarly journals Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in Candida albicans

2020 ◽  
Author(s):  
Ziva Weissman ◽  
Mariel Pinsky ◽  
Rebecca K. Donegan ◽  
Amit R. Reddi ◽  
Daniel Kornitzer
Keyword(s):  
Candida Albicans ◽  
Heme Uptake

scholarly journals Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in Candida albicans

2020 ◽  
Author(s):  
Ziva Weissman ◽  
Mariel Pinsky ◽  
Rebecca K. Donegan ◽  
Amit R. Reddi ◽  
Daniel Kornitzer
Keyword(s):  
Candida Albicans ◽  
Genetic Analysis ◽  
Heme Oxygenase ◽  
Fungal Pathogen ◽  
Heme Uptake ◽  
Host Environment ◽  
Iron Source

ABSTRACTCandida albicans is a major fungal pathogen that can utilize hemin and hemoglobin as iron sources in the iron-scarce host environment. While C. albicans is a heme prototroph, we show here that it can also efficiently utilize external heme as a cellular heme source. Using genetically encoded ratiometric fluorescent heme sensors, we show that heme extracted from hemoglobin and free hemin enter the cells with different kinetics. Heme supplied as hemoglobin is taken up via the CFEM (Common in Fungal Extracellular Membrane) hemophore cascade, and reaches the cytoplasm over several hours, whereas entry of free hemin via CFEM-dependent and independent pathways is much faster, less than an hour. To prevent an influx of extracellular heme from reaching toxic levels in the cytoplasm, the cells deploy Hmx1, a heme oxygenase. Hmx1 was previously suggested to be involved in utilization of hemoglobin and hemin as iron sources, but we find that it is primarily required to prevent heme toxicity. Taken together, the combination of novel heme sensors with genetic analysis revealed new details of the fungal mechanisms of heme import and homeostasis, necessary to balance the uses of heme as essential cofactor and potential iron source against its toxicity.

Enhanced IgE response to Candida albicans in postoperative invasive candidiasis

1996 ◽  
Vol 26 (4) ◽  
pp. 452-460 ◽  
Author(s):  
J. SAVOLAINEN ◽  
A. RANTALA ◽  
M. NERMES ◽  
L. LEHTONEN ◽  
M. VIANDER
Keyword(s):  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Ige Response

Existence of Candida albicans and microorganisms in denture stomatitis patients

1997 ◽  
Vol 24 (10) ◽  
pp. 788-790 ◽  
Author(s):  
Y. KULAK ◽  
A. ARIKAN ◽  
E. KAZAZOGLU
Keyword(s):  
Candida Albicans ◽  
Denture Stomatitis

Importance des micromycètes dans le microbiote intestinal : le modèle Candida albicans.

2018 ◽  
Vol 202 (7) ◽  
pp. 1401-1412
Author(s):  
Alain Bonnin ◽  
Frédéric Dalle
Keyword(s):  
Candida Albicans ◽  
Microbiote Intestinal

Polymorphonuclear leucocyte killing activity of Candida albicans in newborns

1997 ◽  
Vol 56 (1-3) ◽  
pp. 115
Author(s):  
L Siegfried
Keyword(s):  
Candida Albicans ◽  
Polymorphonuclear Leucocyte ◽  
Killing Activity

Antifungal constituents of Curtisia dentata and Maytenus undata active against Cryptococcus neoformans and Candida albicans

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
LJ McGaw ◽  
J Shai ◽  
TA Mokoka ◽  
JN Eloff
Keyword(s):  
Candida Albicans ◽  
Cryptococcus Neoformans

Sprosspilz-positive subkutane Abszessformation unter antifungaler Therapie bei systemischer Candida albicans-Infektion eines 5 Wochen alten Frühgeborenen der 24+4/7 Schwangerschaftswoche

2010 ◽  
Vol 222 (S 01) ◽  
Author(s):  
S Farmand ◽  
H Schützle ◽  
A Struck ◽  
P Henneke ◽  
R Hentschel
Keyword(s):  
Candida Albicans

Einfluss des Trimesters einer Kolonisation mit Candida albicans auf das Schwangerschaftsoutcome

2018 ◽  
Author(s):  
I Holzer ◽  
A Farr ◽  
H Kiss ◽  
M Hagmann ◽  
L Petricevic
Keyword(s):  
Candida Albicans

Candida Albicans Skin Test Reagent

2020 ◽  
Author(s):  
Keyword(s):  
Candida Albicans ◽  
Skin Test
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