scholarly journals Contact allergy to topical diclofenac with systemic tolerance

2021 ◽  
Author(s):  
Caroline Beutner ◽  
Susann Forkel ◽  
Katharina Kreipe ◽  
Johannes Geier ◽  
Timo Buhl
Keyword(s):  
Contact Allergy ◽  
Topical Diclofenac

Contact allergy to tolnaftate

1972 ◽  
Vol 106 (5) ◽  
pp. 715-716 ◽  
Author(s):  
G. A. Gellin
Keyword(s):  
Contact Allergy

Topical Diclofenac Shows Safety for Knee, Hand OA

2011 ◽  
Vol 6 (3) ◽  
pp. 8
Author(s):  
HEIDI SPLETE
Keyword(s):  
Topical Diclofenac

Contact Allergy From Temporary Tattoos

2000 ◽  
Vol 136 (8) ◽  
pp. 1061-a-1062 ◽  
Author(s):  
A. Tosti
Keyword(s):  
Contact Allergy

Topical Diclofenac-Loaded Liposomes Ameliorate Laser-Induced Choroidal Neovascularization in Mice and Non-Human Primates

2017 ◽  
Vol 14 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Masamitsu Shimazawa ◽  
Yuki Inoue ◽  
Tomomi Masuda ◽  
Risako Onodera ◽  
Kohei Tahara ◽  
...  
Keyword(s):  
Choroidal Neovascularization ◽  
Topical Diclofenac

Nickel Allergy of the Skin and Beyond

2020 ◽  
Vol 20 (7) ◽  
pp. 1003-1009
Author(s):  
Malena Gergovska ◽  
Razvigor Darlenski ◽  
Jana Kazandjieva
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Contact Allergy ◽  
Correct Diagnosis ◽  
Large Population ◽  
Modern World ◽  
Nickel Allergy ◽  
Positive Skin ◽  
Diagnostic Potential ◽  
Allergic Contact

Background: Hypersensitization to nickel is one of the most common contact allergies in the modern world and it is considered to be a major cause of contact dermatitis, especially for hand eczema. Objective: The aim of this paper is to describe many faces of the nickel allergy and to find out different diagnostic, potential strategies for treatment and prevention in hypersensitized patients. A personal clinical experience with practical clinical cases of contact dermatitis to nickel has also been presented. Methods: Electronic databases on this topic was carried out using PubMed-Medline. Results: The literature review identified many articles reporting for nickel contact allergy and pointing the metal as number one allergen in the frequency of positive skin patch test reactions in a large population worldwide. Herein, a summary of the current understanding and evidence on nickel allergy with practical approach and proposed recommendations to the dermatologist, general practitioner, and the allergist were prepared. Conclusions: The prevalence of nickel allergy represents an important socio-economical and health issue. Metal is one of the most common sensitizing agents worldwide. The morbidity due to this metal represents the allergic contact dermatitis and it is constantly growing in many countries. There are also cases of systemic allergic contact dermatitis, where they could be easily misdiagnosed as adverse drug reactions, which lead to delay of the correct diagnosis and inappropriate treatment.

Nickel Allergy: Epidemiology, Pathomechanism, Clinical Patterns, Treatment and Prevention Programs

2020 ◽  
Vol 20 (7) ◽  
pp. 992-1002 ◽  
Author(s):  
Marta Tramontana ◽  
Leonardo Bianchi ◽  
Katharina Hansel ◽  
Daniela Agostinelli ◽  
Luca Stingeni
Keyword(s):  
Contact Dermatitis ◽  
Contact Allergy ◽  
Systemic Exposure ◽  
Prevention Programs ◽  
Nickel Allergy ◽  
Type Iv ◽  
Treatment And Prevention ◽  
Typical Type ◽  
Clinical Patterns ◽  
Allergic Contact

Nickel is the most common cause of contact allergy in the general population and the most frequently detected allergen in patients patch tested for suspected allergic contact dermatitis (ACD). ACD from nickel is a typical type IV hypersensitivity. Nickel allergy is mostly caused by nonoccupational exposure, such as jewelry and clothing decorations, metal tools, medical devices (mainly orthopedic and orthodontic implants, cardiovascular prosthesis), eyeglasses, utensils, keys, pigment for paint, cosmetics, and food (mainly legumes, chocolate, salmon, peanuts). Occupational exposure can involve several workers (mechanics, metalworkers, platers, hairdressers, jewelers, workers in the constructions and electronic industries), classically involving hands and forearms. The classic clinical pattern of ACD caused by nickel is characterized by eczematous dermatitis involving the sites of direct contact with the metal. Non-eczematous-patterns are reported, including lichenoid dermatitis, granuloma annulare, vitiligo-like lesions, dyshidrosiform dermatitis, and vasculitis. In the case of systemic exposure to nickel, sensitized patients could develop systemic contact dermatitis. Patch testing represents the gold standard for the diagnosis of ACD from nickel. Treatment includes avoidance of contact with products containing nickel and the patient’s education about the possible use of alternative products. A recent EU nickel directive, regulating the content and release of nickel from products, has caused a decrease of nickel contact allergy in some European countries. Nickel allergy is a relevant issue of public health with significant personal, social, and economic impact. This review summarizes epidemiology, pathomechanism, clinical patterns, treatment, and prevention programs.

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