Optimizing Precision of Hypertension Care to Maximize Blood Pressure Control: A Pilot Study Utilizing a Smartphone App to Incorporate Plasma Renin Activity Testing

1. In twenty-three uraemic patients on regular dialysis, plasma renin activity and blood volume were measured before and after a single dialysis. Three groups were identified; the first had a low or normal plasma renin activity and a high or normal blood volume, the second had a high plasma renin activity and a low blood volume and the third had both variables above normal. 2. In spite of these differences, diastolic blood pressure before and after dialysis was the same in the three groups and multiple regression analyses failed to demonstrate any dependence of blood pressure on plasma renin activity, blood volume or body weight taken separately or together. 3. We conclude that other factors besides plasma renin activity and blood volume are important in maintaining arterial hypertension in terminal renal failure.

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Effects of the Oral Angiotensin-Converting Enzyme Inhibitor MK-421 in Human Hypertension

Clinical Science ◽

10.1042/cs061281s ◽

1981 ◽

Vol 61 (s7) ◽

pp. 281s-283s ◽

Cited By ~ 11

Author(s):

H. Gavras ◽

J. Biollaz ◽

B. Waeber ◽

H. R. Brunner ◽

Gavras Irene ◽

...

Keyword(s):

Blood Pressure ◽

Angiotensin Converting Enzyme ◽

Plasma Renin Activity ◽

Enzyme Inhibitor ◽

Plasma Renin ◽

Pressure Control ◽

Renin Activity ◽

Converting Enzyme ◽

Blood Pressure Fall ◽

Plasma Angiotensin

1. The effects of the new oral angiotensin-converting enzyme (ACE) inhibitor MK-421 on blood pressure, plasma renin activity, angiotensin II, aldosterone and converting enzyme activity were assessed in 16 hypertensive patients followed for 6–18 weeks. 2. After an initial titration period, maintenance doses of 2.5–40 mg once daily produced satisfactory blood pressure control in 11 and a partial but significant decrease in the remainder. 3. Treatment was associated with no change in heart rate and no orthostatic hypotension. At 24 h after the first effective dose, blood pressure was still decreased, plasma ACE was suppressed to 16% of the baseline, plasma angiotensin to 58%, aldosterone to 42%, and plasma renin activity was elevated to 228% of the baseline. 4. Magnitude of blood pressure fall was significantly correlated with the height of pretreatment blood pressure but not with baseline levels of plasma renin activity.

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Effect of salt depletion and propranolol on blood pressure and plasma renin activity in various forms of hypertension.

Circulation Research ◽

10.1161/01.res.36.6.248 ◽

1975 ◽

Vol 36 (6) ◽

pp. 248-256 ◽

Cited By ~ 25

Author(s):

G G Geyskes ◽

P Boer ◽

J Vos ◽

F H Leenen ◽

E J Mees

Keyword(s):

Blood Pressure ◽

Plasma Renin Activity ◽

Plasma Renin ◽

Renin Activity ◽

Salt Depletion

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Enhancement of the Antihypertensive Effect of Hydrochlorothiazide in Dogs after Suppression of Renin Release by Beta-Adrenergic Blockade

Clinical Science ◽

10.1042/cs0480147 ◽

1975 ◽

Vol 48 (2) ◽

pp. 147-151

Author(s):

C. S. Sweet ◽

M. Mandradjieff

Keyword(s):

Blood Pressure ◽

Plasma Renin Activity ◽

Arterial Blood Pressure ◽

Antihypertensive Effect ◽

Plasma Renin ◽

Renin Activity ◽

Renin Release ◽

Antihypertensive Activity ◽

Adrenergic Blockade ◽

Arterial Blood

1. Renal hypertensive dogs were treated with hydrochlorothiazide (8−2 μmol/kg or 33 μmol/kg daily for 7 days), or timolol (4.6 μmol/kg daily for 4 days), a potent β-adrenergic blocking agent, or combinations of these drugs). Changes in mean arterial blood pressure and plasma renin activity were measured over the treatment period. 2. Neither drug significantly lowered arterial blood pressure when administered alone. Plasma renin activity, which did not change during treatment with timolol, was substantially elevated during treatment with hydrochlorothiazide. 3. When timolol was administered concomitantly with hydrochlorothiazide, plasma renin activity was suppressed and blood pressure was significantly lowered. 4. These observations suggest that compensatory activation of the renin-angiotensin system limits the antihypertensive activity of hydrochlorothiazide in renal hypertensive dogs and suppression of diuretic-induced renin release by timolol unmasks the antihypertensive effect of the diuretic.

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