scholarly journals Identification of human herpes virus 1 encoded micro RNA s in biopsy samples of lower esophageal sphincter muscle during peroral endoscopic myotomy for esophageal achalasia

2019 ◽  
Vol 32 (1) ◽  
pp. 136-142 ◽  
Author(s):  
Yuichiro Ikebuchi ◽  
Tsutomu Kanda ◽  
Haruo Ikeda ◽  
Akira Yoshida ◽  
Takuki Sakaguchi ◽  
...  
Keyword(s):  
Lower Esophageal Sphincter ◽  
Esophageal Achalasia ◽  
Micro Rna ◽  
Peroral Endoscopic Myotomy ◽  
Sphincter Muscle ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Endoscopic Myotomy ◽  
Esophageal Sphincter ◽  
Herpès Virus

scholarly journals Advances in the diagnosis and treatment of achalasia of the cardia: A review

2021 ◽  
Vol 9 (1) ◽  
pp. 24-31
Author(s):  
Baozhen Zhang ◽  
Yidan Wang ◽  
Ye Liao ◽  
Jingjing Zhang ◽  
Yufan Wu ◽  
...  
Keyword(s):  
Lower Esophageal Sphincter ◽  
Peroral Endoscopic Myotomy ◽  
Diagnosis And Treatment ◽  
Pneumatic Dilation ◽  
Motor Disorder ◽  
Sphincter Pressure ◽  
Idiopathic Achalasia ◽  
Retrosternal Pain ◽  
Endoscopic Myotomy ◽  
Esophageal Sphincter

Abstract Idiopathic achalasia is an esophageal motor disorder characterized by the loss of the lower esophageal sphincter ganglion, resulting in impaired lower esophageal relaxation and absence of esophageal peristalsis. Patients commonly present with progressive dysphagia accompanied by reflux, heartburn, retrosternal pain, and severe weight loss. Diagnosis is primarily based on the patient’s chief complaints, barium esophagography, and the most recent high-resolution manometry. Endoscopic assessment and endoscopic ultrasonography also have significant value with regard to the exclusion of esophageal anatomical lesions, neoplastic diseases, and pseudoachalasia. However, as most patients with achalasia demonstrate a gradual onset, early diagnosis is difficult. Currently, treatment of idiopathic achalasia, including pneumatic dilation, stent placement, and surgical myotomy, is aimed at reducing lower esophageal sphincter pressure and relieving the symptoms of dysphagia. Peroral endoscopic myotomy has gradually become the mainstream treatment because it causes less trauma and has a rapid recovery rate. This article reviews the main methods of diagnosis and treatment of achalasia, with an emphasis on the potential of peroral endoscopic myotomy and the advancements of immunotherapy for achalasia.

PERORAL ENDOSCOPIC MYOTOMY IN TREATMENT OF THE ESOPHAGEAL ACHALASIA AT CHILDREN

2020 ◽  
Vol 99 (6) ◽  
pp. 241-246
Author(s):  
Yu.A. Kozlov ◽  
◽  
A.A. Smirnov ◽  
A.A. Rasputin ◽  
P.A. Baradieva ◽  
...  
Keyword(s):  
Esophageal Achalasia ◽  
Peroral Endoscopic Myotomy ◽  
Heller’S Myotomy ◽  
Endoscopic Method ◽  
Therapeutic Procedures ◽  
Heller's Myotomy ◽  
Prolonged Observation ◽  
Endoscopic Myotomy ◽  
Esophageal Sphincter

Etiological treatment of esophageal achalasia are absent. None of the currently available treatment methods can restore normal esophageal peristalsis and the functionality of the lower esophageal sphincter, thereby alleviating dysphagia and other symptoms of achalasia. Therapeutic procedures currently used for the effective treatment of achalasia of the esophagus are represented by laparoscopic Heller's myotomy and endoscopic balloon dilatation of the esophagus. According to the literature, Heller's myotomy is considered as a method of choice in children, since it provides more reliable results in comparison with pneumatic expansion during prolonged observation. Peroral endoscopic myotomy (POEM) is a new endoscopic method for the treatment of esophageal achalasia, first reported by P. Pasricha in experiment, and then H. Inoue performed this operation in adult patients. There are only a few studies on the use of POEM in children and adolescents. Existing studies have demonstrated the feasibility of this procedure in children, low level of complications and excellent results with short-term observation. Several studies have reported high efficacy in the use of POEM in children, ranging from 90% to 100%. Reports of the occurrence of complications after POEM in children are sporadic and are represented by the formation of subcutaneous emphysema, carboperitoneum, retroperitoneum and mediastinal emphysema. Obviously, detailed studies with longer observation are required before the role of POEM in the treatment of esophageal achalasia in children can be established. If preliminary results are confirmed, POEM can be a real alternative to Heller's myotomy in pediatric patients. This study is intended to explore the potential and safety of the use of POEM for the treatment of achalasia in children based on a review of existing data in the scientific literature.

Tu1188 A Meta-Analysis of Prospective Trials: Lower Esophageal Sphincter Pressures in Adult Achalasia Patients Managed With Peroral Endoscopic Myotomy (POEM)

2017 ◽  
Vol 85 (5) ◽  
pp. AB575
Author(s):  
Abhiram Duvvuri ◽  
Vishnu Moole ◽  
Anwesh Poosala ◽  
Raghuveer R. Boddireddy ◽  
Achuta Uppu ◽  
...  
Keyword(s):  
Lower Esophageal Sphincter ◽  
Meta Analysis ◽  
Peroral Endoscopic Myotomy ◽  
Prospective Trials ◽  
Endoscopic Myotomy ◽  
Esophageal Sphincter

scholarly journals Novel technique to relax the lower esophageal sphincter during challenging peroral endoscopic myotomy (POEM)

Endoscopy ◽  
2016 ◽  
Vol 48 (S 01) ◽  
pp. E252-E252
Author(s):  
Majidah Bukhari ◽  
Vivek Kumbhari ◽  
Yamile Haito-Chavez ◽  
Yen-I Chen ◽  
Saowanee Ngamruengphong ◽  
...  
Keyword(s):  
Lower Esophageal Sphincter ◽  
Peroral Endoscopic Myotomy ◽  
Novel Technique ◽  
Endoscopic Myotomy ◽  
Esophageal Sphincter

Peroral Endoscopic Myotomy Is Effective for Patients With Achalasia and Normal Lower-Esophageal Sphincter Relaxation Pressures

2019 ◽  
Vol 17 (13) ◽  
pp. 2803-2805 ◽  
Author(s):  
Madhusudhan R. Sanaka ◽  
Malav P. Parikh ◽  
Prashanthi N. Thota ◽  
Niyati M. Gupta ◽  
Scott Gabbard ◽  
...  
Keyword(s):  
Lower Esophageal Sphincter ◽  
Peroral Endoscopic Myotomy ◽  
Lower Esophageal Sphincter Relaxation ◽  
Endoscopic Myotomy ◽  
Esophageal Sphincter
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