Treatment Option
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2021 ◽  
Vol 57 (4) ◽  
pp. 391-395
Ilinko Vrebac ◽  
Tamara Braut ◽  
Marko Velepič ◽  
Matej Maršić ◽  
Jelena Vukelić ◽  

Renal clear cell metastatic carcinoma of the larynx is an extremely rare diagnosis with poor survival. The objective of this short review is to provide insight into current state of literature on this rare neoplasm. Additionally we include the case of a patient with metastatic process of the thyroid cartilage that was treated with novel targeted therapies which enabled prolonged survival and good quality of life. These findings support their inclusion in treatment protocols of patients with metastatic renal clear cell carcinoma of the larynx, especially in those refusing surgery which is the main treatment option in literature so far.

2021 ◽  
Vol 18 (4) ◽  
pp. 39-43
Bikash Khadka ◽  
Saroj Poudel

Treatment of central nervous system infection may be troublesome due to multi-drug resistance. Colistin is less successful as a treatment option due to poor CNS penetration when used intravenously. We present the successful management of a case with ventriculitis and meningitis due to MDR Acinetobacter baumannii species with the combined intraventricular administration of colistin and IV fosfomycin after the initial regimen of colistin given alone through both IVT and IV routes had failed.

Samyak Pandey ◽  
Jayesh Mudgal

AbstractInjury to the peripheral nerve is traditionally referred to acquired nerve injury as they are the result of physical trauma due to laceration, stretch, crush and compression of nerves. However, peripheral nerve injury may not be completely limited to acquired physical trauma. Peripheral nerve injury equally implies clinical conditions like Guillain-Barré syndrome (GBS), Carpal tunnel syndrome, rheumatoid arthritis and diabetes. Physical trauma is commonly mono-neuropathic as it engages a single nerve and produces focal damage, while in the context of pathological conditions the damage is divergent involving a group of the nerve causing polyneuropathy. Damage to the peripheral nerve can cause a diverse range of manifestations from sensory impairment to loss of function with unpredictable recovery patterns. Presently no treatment option provides complete or functional recovery in nerve injury, as nerve cells are highly differentiated and inert to regeneration. However, the regenerative phenotypes in Schwann cells get expressed when a signalling cascade is triggered by neurotrophins. Neurotrophins are one of the promising biomolecules that are released naturally post-injury with the potential to exhibit better functional recovery. Pharmacological intervention modulating the expression of these neurotrophins such as brain-derived neurotrophic factor (BDNF) and pituitary adenylyl cyclase-activating peptide (PACAP) can prove to be a significant treatment option as endogenous compounds which may have remarkable innate advantage showing maximum ‘biological relevance’. Graphical abstract

Beenish Abbas ◽  
Sidra Aamer ◽  
Fizza Sahar Anwar ◽  
Farah Farhan ◽  
Mehreen Wajahat ◽  

Abstract Objectives The aim of this study was to survey the educational experiences, knowledge, and attitude of dentists in Pakistan about the professional use of silver diamine fluoride (SDF). This study also aimed to determine if SDF educational experience at the undergraduate level can result in a more positive attitude and increased clinical usage of SDF. Materials and Methods This was a cross-sectional survey, conducted at multiple dental institutes across Pakistan using a pre-validated questionnaire to assess the knowledge, experience, and professional expertise of dentists regarding the use of SDF. The data were entered and analyzed using the SPSS (version 23.0) data management software by IBM. Results The results of this study were deemed significant in terms of achievement of the study aims. The majority of the responders, 178 (79.8%), reported online resources to be the main source of information about SDF treatment, whereas 103 (46.1%) responders gained information from a dental journal. A higher number of consultants were reported to be well educated regarding SDF treatment during their residency training as compared with demonstrators, house officers, and postgraduate trainees (p < 0.001). About 64 (28.7%) responders agreed that SDF is a better alternative treatment for children with behavioral issues, 74 (33.2%) agreed that it is a better treatment option for medically fragile patients, and 79 (35.4%) agreed that it can be used as an alternative for patients with dental anxiety. It was agreed by 82 (36.8%) responders that SDF is a good treatment option for patients who recently have received chemotherapy radiation therapy. Conclusion It is the need of time to put all educational efforts together to enhance knowledge regarding the use, advantages, and potential problems of SDF.

2021 ◽  
Narayan Bhandari ◽  
Manojkumar Bhandari ◽  
Ian Littlehales ◽  
Sean Potter

Abstract Metal sulfide scaling issue in the oil and gas production continue to present significant flow assurance challenge. Recently, a novel polymeric chemistry that can effectively control FeS scale deposition in oil and gas production system was reported. However, how to manage finely dispersed FeS particulates at surface disposal facilities and whether this polymer is capable of mitigating ZnS and PbS deposition is largely unknown. Therefore, this study continues to seek an efficient treatment option for metal sulfide scale management. Static bottle tests and dynamic scale loop tests under anoxic conditions were conducted to understand the efficacy of the novel polymeric chemistry towards metal sulfide scaling control. To mimic various field conditions; individual metal sulfide (FeS, ZnS and PbS) as well as mixed scaling scenarios were simulated. Various coagulant and oxidant chemistries were tested to understand the impact of the upstream treatment on safe disposal of FeS nanoparticles at surface facilities. This novel polymeric chemistry was found to be not only effective towards FeS scaling control, but also towards dispersion of ZnS and PbS as well. The primary mechanism of metal sulfide scale deposition control is identified to be crystal growth inhibition and crystal surface modification. Laboratory test results indicated no negative impact of new chemistry on the performance of other chemicals (coagulant, oxidizer etc.). In fact, an enhanced efficiency of iron sulfide oxidation was observed possibly due to the large surface area of finely dispersed particles. A field throughput study results indicated superior performance compared to that of various incumbent chemistries. Based on the laboratory results, it is anticipated that this chemistry will provide a new treatment option for metal sulfide scaling/deposition control. Additionally, the new chemistry did not leave any negative footprint for safe disposal of metal sulfide particulate at surface. As opposed to the calcite/barite scale, nucleation inhibition of metal sulfide may not be desired as the dissolved sulfide may cause further corrosion/deposition downstream. Therefore, the value this paper brings to the management of metal sulfides is a systematic testing and evaluation approach which confirms dispersion rather than nucleation inhibition is effective control mechanism.

2021 ◽  
pp. 1-3
Anja Malmendier-Muehlschlegel ◽  
Niamh Catherine Power

The article provides a brief overview of the legislation governing involuntary admissions to psychiatric hospitals in Luxembourg. The legislation was completely overhauled in 2009 and several human rights principles are enshrined into it. Emphasis is placed on voluntary, community-based treatment, and where compulsory treatment is required, it uses the least restrictive treatment option. Mentally ill offenders are dealt with through separate specialist legislation. Young people under the age of 18 are often detained using family law.

Tong Yu ◽  
Xi-Wen Zhang ◽  
Ping-Li Sun ◽  
Abdulkarim Mohamed Farah ◽  
Yan Jia

Conclusions: Molecular classification could provide reliable supplementary information for evaluating prognostic and contribute to treatment option decision-making in EEC patients. Fertility-sparing treatment is not recommended for EEC patients with CNH and MSI-H. Furthermore, fertility-sparing treatment can be attempted in EEC patients with CHL, but regular follow-up should be carried out to early detection of EC relapse and prevention of disease progression.

Namdeo Prabhu ◽  
Amjad Abdulrahman S. Albulayhid ◽  
Abdulaziz Abdolah Y. Althari ◽  
Talal Eid Q. Alruwaili

Fixed partial dentures (FPDs) made of metal ceramic are a popular treatment option for missing teeth. Studies have shown that posterior abutments of FPDs had a higher pulp survival rate than anterior abutments. Postoperative sensitivity following the cementation of a fixed prosthesis is a frequent symptom, especially when the abutments include important pulp. Dentinal hypersensitivity affects between 4 and 74 percent of people. Females are found to have a somewhat greater DH incidence than males. While DH can affect individuals of any age, there have been several theories on what causes abutment sensitivity after tooth preparation and cementation. In this review we included some of it. Also, we discussed methods of management of postoperative sensitivity and Management of fractured abutment screw.

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