scholarly journals Glycogen Synthase Kinase 3 influences cell motility and chemotaxis by regulating PI3K membrane localization inDictyostelium

2013 ◽  
Vol 55 (8) ◽  
pp. 723-734 ◽  
Author(s):  
Tong Sun ◽  
Bohye Kim ◽  
Lou W. Kim
Keyword(s):  
Cell Motility ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Membrane Localization

scholarly journals Glycogen synthase kinase 3 (GSK-3) controls T-cell motility andinteractions with antigen presenting cells

2020 ◽  
Author(s):  
Alison Taylor ◽  
Christopher E. Rudd
Keyword(s):  
T Cell ◽  
Cell Motility ◽  
Glycogen Synthase ◽  
Antigen Presenting Cells ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Negative Effects ◽  
Serine Kinase ◽  
Multiple Substrates ◽  
Antigen Presenting

Abstract Objective: The threonine/serine kinase glycogen synthase kinase 3 (GSK-3) targets multiple substrates in T-cells and regulates the expression of Tbet and PD-1. However, it has been unclear whether GSK-3 has any effect on T-cell motility or their interactions with antigen presenting cells. Results: Here, we show that GSK-3 controls T-cell motilityand interactions with other cells. Inhibition of GSK-3, using structurally distinct inhibitors, reduced T-cell motility in terms of speed and distance travelled. Furthermore, SB415286 reduced the number of cell to cell contacts, however the duration of these established contacts with other cells did not differ in the presence of SB415286. This inhibition of motility did not affect the ability of GSK-3 inhibitors to enhance cytolytic T-cell (CTL) function in killing tumor targets. These data show that the inhibition of GSK-3 has differential effects on T-cell motility and CTL function where the negative effects on cell-cell interactions is overridden by the increased cytolytic potential of CTLs.

scholarly journals Glycogen synthase kinase 3 (GSK-3) controls T-cell motility andinteractions with antigen presenting cells

2020 ◽  
Author(s):  
Alison Taylor ◽  
Christopher E. Rudd
Keyword(s):  
T Cell ◽  
Cell Motility ◽  
Glycogen Synthase ◽  
Antigen Presenting Cells ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Negative Effects ◽  
Serine Kinase ◽  
Multiple Substrates ◽  
Antigen Presenting

Abstract Objective:The threonine/serine kinase glycogen synthase kinase 3 (GSK-3) targets multiple substrates in T-cells and regulates the expression of Tbet and PD-1. However, it has been unclear whether GSK-3 has any effect on T-cell motility or their interactions with antigen presenting cells. Results: Here, we show that GSK-3 controls T-cell motilityand interactions with other cells. Inhibition of GSK-3, using structurally distinct inhibitors, reduced T-cell motility in terms of speed and distance travelled. Furthermore, SB415286 reduced the number of cell to cell contacts, however the duration of these established contacts with other cells did not differ in the presence of SB415286. This inhibition of motility did not affect the ability of GSK-3 inhibitors to enhance cytolytic T-cell (CTL) function in killing tumor targets. These data show that the inhibition of GSK-3 has differential effects on T-cell motility and CTL function where the negative effects on cell-cell interactions is overridden by the increased cytolytic potential of CTLs.

scholarly journals Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells

2019 ◽  
Author(s):  
Alison Taylor ◽  
Christopher E. Rudd
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Motility ◽  
Glycogen Synthase ◽  
Antigen Presenting Cells ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Serine Kinase ◽  
Multiple Substrates ◽  
Antigen Presenting

Abstract Objective: The threonine/serine kinase glycogen synthase kinase 3 (GSK-3) targets multiple substrates in T-cells, regulating the expression of Tbet and PD-1 on T-cells. However, it has been unclear whether GSK-3 can affect the motility of T-cells and their interactions with antigen presenting cells. Results: Here, we show that GSK-3 can regulate T-cell motility. Inhibition of GSK-3, by small molecule SB415286, reduced T-cell motility in terms of distance and displacement. Although SB415286 reduced the number of contacts, the dwell times of established contacts did not differ between T-cells treated with SB415286. These data indicate show that the inhibition of GSK-3 can influence the motility of T-cells and interactions with other cells without affecting the dwell times of cells that make productive contacts.

scholarly journals Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells

2019 ◽  
Author(s):  
Alison Taylor ◽  
Christopher E. Rudd
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Motility ◽  
Glycogen Synthase ◽  
Antigen Presenting Cells ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Serine Kinase ◽  
Multiple Substrates ◽  
Antigen Presenting

Abstract Objective: The threonine/serine kinase glycogen synthase kinase 3 (GSK-3) targets multiple substrates in T-cells, regulating the expression of Tbet and PD-1 on T-cells. However, it has been unclear whether GSK-3 can affect the motility of T-cells and their interactions with antigen presenting cells. Results: Here, we show that GSK-3 can regulate T-cell motility. Inhibition of GSK-3, by small molecule SB415286, reduced T-cell motility in terms of distance and displacement. Although SB415286 reduced the number of contacts, the dwell times of established contacts did not differ between T-cells treated with SB415286. These data indicate show that the inhibition of GSK-3 can influence the motility of T-cells and interactions with other cells without affecting the dwell times of cells that make productive contacts.

Glycogen synthase kinase-3 alpha

2008 ◽  
Author(s):  
Richard Jope
Keyword(s):  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3
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