Add-on treatment with intermediate-acting insulin versus sliding-scale insulin for patients with type 2 diabetes or insulin resistance during cyclic glucocorticoid-containing antineoplastic chemotherapy: a randomized crossover study

2016 ◽  
Vol 18 (10) ◽  
pp. 1041-1044 ◽  
Author(s):  
M. C. Gerards ◽  
J. S. de Maar ◽  
T. G. Steenbruggen ◽  
J. B. L. Hoekstra ◽  
T. M. Vriesendorp ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Crossover Study ◽  
Acting Insulin ◽  
Intermediate Acting Insulin ◽  
Sliding Scale ◽  
Randomized Crossover Study ◽  
Antineoplastic Chemotherapy

755-P: A Plant-Based Meal Stimulates Incretin and Insulin Secretion More than an Energy- and Macronutrient-Matched Standard Meal in Type 2 Diabetes: A Randomized Crossover Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 755-P
Author(s):  
HANA KAHLEOVA ◽  
ANDREA TURA ◽  
MARTA KLEMENTOVA ◽  
LENKA BELINOVA ◽  
MARTIN HALUZIK ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Crossover Study ◽  
Standard Meal ◽  
Randomized Crossover Study

scholarly journals Dietary Intervention with Oatmeal in Patients with uncontrolled Type 2 Diabetes Mellitus – A Crossover Study

2018 ◽  
Vol 127 (09) ◽  
pp. 623-629 ◽  
Author(s):  
Graciela Delgado ◽  
Marcus E. Kleber ◽  
Bernhard K Krämer ◽  
Michael Morcos ◽  
Per M. Humpert ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Crossover Study ◽  
Dietary Intervention ◽  
Control Period ◽  
Insulin Requirement ◽  
Control Treatment ◽  
Daily Insulin

Abstract Background In a pilot study, we evaluated the efficacy of two days of oatmeal on insulin resistance and glucose metabolism and found a marked decrease of insulin requirements. The most important shortcoming of that study was that the interventions were not isocaloric (diabetes adapted diet: 1500 kcal/d vs. oatmeal 1100 kcal/d). To address these drawbacks we designed the OatMeal And Insulin Resistance (OMA-IR) study. Methods The study was a randomized, open label crossover dietary intervention study with consecutive inclusion of 15 patients with uncontrolled type 2 diabetes. The intervention comprised two days of oatmeal on days 3 and 4 of a 5 days hospital stay. During the control period, patients received a diabetes mellitus adapted diet only. The primary endpoint was the daily insulin requirement and glycemic control. Results Upon oatmeal treatment, the required insulin dose could be significantly reduced on the third and fourth day as compared to the second day of inpatient stay (82.0±30.3 and 69.9±29.9IU versus 112±36.2IU;P<0.001). During control treatment, insulin requirement did not change. There were no significant differences in the changes of mean blood glucose or fasting glucose between both treatments. HbA1c was lower four weeks after the oatmeal intervention. Conclusion In this crossover study, two days of oatmeal intervention allowed a highly significant reduction of required daily insulin doses while maintaining adequate metabolic control as compared to a diabetes adapted diet only. The beneficial effects of the intervention might last for several weeks as shown by the lower HbA1c four weeks after the intervention.

scholarly journals Effectiveness of Dose Adjustment of Insulin in Type 2 Diabetes among Hemodialysis Patients with End-Stage Renal Disease: A Randomized Crossover Study

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Amol Singhsakul ◽  
Ouppatham Supasyndh ◽  
Bancha Satirapoj
Keyword(s):  
Type 2 Diabetes ◽  
Renal Disease ◽  
Crossover Study ◽  
End Stage Renal Disease ◽  
Hemodialysis Patients ◽  
Insulin Group ◽  
Stage Renal Disease ◽  
End Stage ◽  
Randomized Crossover Study

Determining insulin requirements for hemodialysis patients with end-stage renal disease (ESRD) is difficult. We performed a randomized crossover study among type 2 diabetes (T2DM) patients with ESRD on continuous hemodialysis and receiving standard insulin for glycemic control. The patients were randomized in 2 groups: daily insulin needed on the day after hemodialysis and a 25% decrease in daily insulin needed on the day after hemodialysis. A total of 51 T2DM patients with ESRD were enrolled. The adjusted-insulin group had higher plasma glucose levels at the 2nd hour of dialysis than those of the nonadjusted-insulin group. Incidence of hypoglycemia per dialysis session (3.3% vs. 0.7%, P=0.02) and symptoms related to hypoglycemia (6.9% vs. 0.7%, P=0.001) were more frequent in the nonadjusted-insulin group. A reduced insulin administration of 25% among T2DM patients undergoing hemodialysis on the day of dialysis was associated with sustained glycemic efficacy and the production of fewer hypoglycemic symptoms. This trial is registered with TCTR20180724002.

scholarly journals Appropriate insulin regimes for type 2 diabetes: a multicenter randomized crossover study

Diabetes Care ◽  
2000 ◽  
Vol 23 (11) ◽  
pp. 1612-1618 ◽  
Author(s):  
R. Taylor ◽  
R. Davies ◽  
C. Fox ◽  
M. Sampson ◽  
J. U. Weaver ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Crossover Study ◽  
Randomized Crossover Study

scholarly journals Randomized Crossover Study to Examine the Necessity of an Injection-to-Meal Interval in Patients With Type 2 Diabetes and Human Insulin

Diabetes Care ◽  
2013 ◽  
Vol 36 (7) ◽  
pp. 1865-1869 ◽  
Author(s):  
N. Muller ◽  
T. Frank ◽  
C. Kloos ◽  
T. Lehmann ◽  
G. Wolf ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Crossover Study ◽  
Human Insulin ◽  
Randomized Crossover Study
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