scholarly journals Association between uric acid, renal haemodynamics and arterial stiffness over the natural history of type 1 diabetes

2019 ◽  
Vol 21 (6) ◽  
pp. 1388-1398 ◽  
Author(s):  
Yuliya Lytvyn ◽  
Petter Bjornstad ◽  
Julie A. Lovshin ◽  
Sunita K. Singh ◽  
Genevieve Boulet ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Uric Acid ◽  
Natural History ◽  
Arterial Stiffness ◽  
Renal Haemodynamics ◽  
History Of

Abstract P059: Association Of Uric Acid With Change In Arterial Stiffness And Blood Pressure Over Time In Type 1 Diabetes Mellitus: The SEARCH For Diabetes In Youth Study

Hypertension ◽  
2020 ◽  
Vol 76 (Suppl_1) ◽  
Author(s):  
Andrew M South ◽  
Joseph Rigdon ◽  
Jeanette M Stafford ◽  
Dana Dabelea ◽  
Jean Lawrence ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Uric Acid ◽  
Arterial Stiffness ◽  
Cvd Risk ◽  
History Of ◽  
Youth Study ◽  
Multivariable Regression Models ◽  
Diabetes In Youth ◽  
Over Time

Background: Type 1 diabetes (T1D) increases CVD risk, and early detection of CV changes could mitigate CVD risk. Increased arterial stiffness is an early marker of adverse CV health and precedes hypertension. Uric acid has been associated with arterial stiffness, hypertension, and CVD in select conditions such as obesity, but its relationship to T1D is undefined. We hypothesized that uric acid predicts increased arterial stiffness and BP over time in youth with T1D, especially those with overweight/obesity. Methods: Prospective cohort of 451 participants with T1D from the SEARCH for Diabetes in Youth Study. We measured uric acid, BP, and arterial stiffness assessed by pulse wave velocity (PWV) in the arm (PWV-R), trunk (PWV-T), and lower extremity (PWV-LE). BP and PWV were repeated a mean of 4.5 years later (±1.1). We defined high BP as ≥90 th %ile for age/sex/height (<13 years) and ≥120/80 mmHg (≥13 years). We applied multivariable regression models to estimate the association of uric acid with annualized changes in each outcome. Directed acyclic graph-informed models were adjusted for age, sex, race/ethnicity, health insurance, family history of CVD, A1c, antihypertensive use, T1D duration, dyslipidemia, and study site. We assessed for effect modification by overweight/obesity. Results: Mean age was 18.1 years (±4.5), 50.8% (229/451) were female, 66.1% (298/451) were White, and 42.4% (191/451) had overweight/obesity. A 1 mg/dl increase in uric acid was associated with increased PWV-R (adjusted β : 0.02 m/s/year, 95% CI -0.01 to 0.06), decreased SBP (-0.45 mmHg/year, -0.73 to -0.18), and sustained high BP (referenced to normal BP, adjusted OR 1.28, 0.91 to 1.79), but not PWV-T or PWV-LE. Compared to normal BMI, those with overweight/obesity demonstrated somewhat stronger associations between uric acid and PWV-R (0.05 m/s/year, 0.0 to 0.1 vs. 0.0 m/s/year, -0.05 to 0.05, interaction p =0.17) and sustained high BP (1.58, 0.99 to 2.51 vs. 0.79, 0.44 to 1.4, interaction p =0.06). Discussion: Among participants with T1D, uric acid was modestly associated with changes in PWV-R and BP over time, particularly in those with overweight/obesity. Further investigations are warranted to determine uric acid’s role in hypertension and arterial stiffness in T1D.

The reconstructed natural history of type 1 diabetes mellitus

2019 ◽  
Vol 15 (5) ◽  
pp. 256-257 ◽  
Author(s):  
Paolo Pozzilli ◽  
Alberto Signore
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Natural History ◽  
Type 1 Diabetes Mellitus ◽  
History Of

P46 Natural history of hyperglycaemia in children not due to type-1 diabetes

1999 ◽  
Vol 44 ◽  
pp. S26
Author(s):  
S. Salardi ◽  
S. Zucchini ◽  
L. Ragni ◽  
B. Mainetti ◽  
E. Cacciari
Keyword(s):  
Type 1 Diabetes ◽  
Natural History ◽  
History Of

scholarly journals C-peptide in the natural history of type 1 diabetes

2009 ◽  
Vol 25 (4) ◽  
pp. 325-328 ◽  
Author(s):  
Jerry P. Palmer
Keyword(s):  
Type 1 Diabetes ◽  
Natural History ◽  
C Peptide ◽  
History Of

scholarly journals The Early Natural History of Nephropathy in Type 1 Diabetes: III. Predictors of 5-Year Urinary Albumin Excretion Rate Patterns in Initially Normoalbuminuric Patients

Diabetes ◽  
2005 ◽  
Vol 54 (7) ◽  
pp. 2164-2171 ◽  
Author(s):  
J. M. Steinke ◽  
A. R. Sinaiko ◽  
M. S. Kramer ◽  
S. Suissa ◽  
B. M. Chavers ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Natural History ◽  
Urinary Albumin Excretion ◽  
Excretion Rate ◽  
Albumin Excretion Rate ◽  
Urinary Albumin ◽  
Urinary Albumin Excretion Rate ◽  
Albumin Excretion ◽  
History Of

scholarly journals PDB21 Natural History of Beta Cell Rate of Decline and Its Effect on Development of Secondary Complications in Type 1 Diabetes

2011 ◽  
Vol 14 (7) ◽  
pp. A475
Author(s):  
R.D. Rodriguez ◽  
K. Sarsour ◽  
B. Mitchell ◽  
L. Bowman
Keyword(s):  
Type 1 Diabetes ◽  
Natural History ◽  
Beta Cell ◽  
Secondary Complications ◽  
History Of ◽  
Rate Of Decline

scholarly journals Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

Diabetes ◽  
2015 ◽  
Vol 65 (3) ◽  
pp. 719-731 ◽  
Author(s):  
Martha Campbell-Thompson ◽  
Ann Fu ◽  
John S. Kaddis ◽  
Clive Wasserfall ◽  
Desmond A. Schatz ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Natural History ◽  
Cell Mass ◽  
Β Cell ◽  
History Of

Advances in the Prediction and Natural History of Type 1 Diabetes

2010 ◽  
Vol 39 (3) ◽  
pp. 513-525 ◽  
Author(s):  
Ezio Bonifacio ◽  
Anette G. Ziegler
Keyword(s):  
Type 1 Diabetes ◽  
Natural History ◽  
History Of
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