STAT3
            ‐mutated hyperimmunoglobulin E syndrome with perianal skin tags and erosions: A case report

Fistula in ano is an abnormal communication between anal canal or rectum and the perianal skin which mostly follows previous ano-rectal abscess. Chief complaints include intermittent discharge, history of pre-vious pain, swelling and recurrent abscess that ruptured spontaneously or was drained surgically. Various surgical and para-surgical methods are available now a days to treat this disease. In the vast literature of Ayurveda same symptoms are described as Bhagandara. At first it appears as Pidika around Guda and when it bursts out, it is called as Bhagandara1. Acharya Sushruta has counted this disease in Ashta Ma-hagada suggesting its difficulty to treat2. There are many options available to treat fistula in ano ranging from seton application, fistulotomy, fistulectomy, fibrin glues, LIFT technique, advancement flaps etc. Acharyas has used Agni karma, Kshara karma, Shastra karma and Aushadha karma in Bhagndara. But in this case Kshara Sootra application was done to treat Bhagandara. Application of Kshara Sootra not only lessen rate of recurrence to a significant level but also free from almost all major post-operative complica-tion.

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Atopic dermatitis, short stature, skeletal malformations, hyperimmunoglobulin E syndrome, hypereosinophilia and recurrent infections: a case report

Journal of Medical Case Reports ◽

10.1186/1752-1947-7-253 ◽

2013 ◽

Vol 7 (1) ◽

Cited By ~ 1

Author(s):

Salvatore Leonardi ◽

Martina Filippelli ◽

Valentina Costanzo ◽

Novella Rotolo ◽

Mario La Rosa

Keyword(s):

Atopic Dermatitis ◽

Case Report ◽

Short Stature ◽

Recurrent Infections ◽

Skeletal Malformations ◽

Hyperimmunoglobulin E Syndrome

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Pediatric hyperimmunoglobulin E syndrome (Job's syndrome) with STAT3 mutation: A case report

Annals of Medicine and Surgery ◽

10.1016/j.amsu.2021.102452 ◽

2021 ◽

pp. 102452

Author(s):

Namita Bhutani ◽

Urvashi Sharma ◽

Ashok Kumar ◽

Pradeep Kajal

Keyword(s):

Case Report ◽

Job’S Syndrome ◽

Hyperimmunoglobulin E Syndrome ◽

Stat3 Mutation ◽

Job's Syndrome

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Glyceryl Trinitrate Ointment Did Not Reduce Pain After Stapled Hemorrhoidectomy: A Randomized Controlled Trial

International Surgery ◽

10.9738/cc92.1 ◽

2012 ◽

Vol 97 (2) ◽

pp. 112-119 ◽

Cited By ~ 6

Author(s):

Trent Cross ◽

Lynne Bartlett ◽

Chrispen Mushaya ◽

Mohamed Ashour ◽

Yik-Hong Ho

Keyword(s):

Postoperative Pain ◽

Glyceryl Trinitrate ◽

Controlled Trial ◽

Perianal Skin ◽

Stapled Hemorrhoidopexy ◽

Control Group ◽

Stapled Hemorrhoidectomy ◽

Recurrence Rates ◽

Skin Tags ◽

Pain Duration

Abstract Medications, including topical 0.2% glyceryl trinitrate (GTN), can reduce anal spasm and pain after excisional hemorrhoidectomy. GTN after stapled hemorrhoidopexy was compared with routine postoperative management. Patients with symptomatic grade 3/4 hemorrhoids were recruited. After stapled hemorrhoidopexy, residual perianal skin tags were excised as appropriate. Those requiring double purse-string mucosectomy were excluded. Postoperative pain, pain duration, and complications were assessed. One hundred ten patients (74 men; mean age 50.6 years) were enrolled in the control group and 100 patients (57 men; mean age 49.8 years) in the GTN group. Maximum pain was higher in the GTN group (P = 0.015). There were no differences between the two groups in residual perianal skin tags requiring excision, postoperative complications, recurrence rates, follow-up period, average pain, duration of pain, or satisfaction scores. Sixteen GTN patients were noncompliant due to side effects. None had persistent perianal skin tags. GTN did not reduce postoperative pain after stapled hemorrhoidectomy.

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