An Unusual Localization of a Cardiac Pseudoaneurysm Complicated by Paravalvular Leak in a Patient with Prosthetic Heart Valves

Heart valve diseases account for a significant portion of hospitalizations due to cardiovascular diseases in Brazil. Prosthetic heart valves, which are often part of treatment, are susceptible to complications, such as paravalvular leak. Surgical intervention remains the treatment of choice for correcting this defect. However, transesophageal echocardiography-guided catheter correction has emerged as a less invasive alternative for paravalvular leak treatment in patients at high surgical risk. We report a case of extensive mitral paravalvular leak in a patient who had two previous cardiac surgeries and a high surgical risk, who underwent successful transcatheter closure with three prosthesis implantation by transapical access.

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Is TEE a Game Changer in Aortic Prosthetic Paravalvular Leak?

Journal of Cardiac Critical Care TSS ◽

10.1055/s-0039-1696909 ◽

2019 ◽

Vol 03 (01) ◽

pp. 42-44

Author(s):

Devishree Das ◽

Lakshya Sehgal ◽

Ameya karanjkar ◽

Sandeep Sharan ◽

Poonam Malhotra Kapoor

Keyword(s):

Prosthetic Valve ◽

Heart Valves ◽

Three Dimensional ◽

Prosthetic Heart Valve ◽

Paravalvular Leak ◽

Prosthetic Heart Valves ◽

Valve Prosthesis ◽

Almost All ◽

Axis View ◽

Game Changer

AbstractValve prosthesis have played an important role in the management of patients with valvular heart disease. However, the prosthetic heart valves used are not without complications. Almost all prosthetic heart valves are obstructive compared with native valves and associated with physiological washing jets. Because of shielding and artifacts it is very difficult to assess the prosthetic valve with TTE. Multiple thrombi and aortomitral continuity detection is cumbersome by TTE. Multiple angulations and off axis view in TEE help not only to characterize the prosthetic heart valve but also gives a three-dimensional surgical view to aid in reaching a diagnosis.

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The Effect of Dipyridamole and RA 233 on Human Platelet Function in Vitro

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648112 ◽

1973 ◽

Vol 29 (03) ◽

pp. 694-700 ◽

Cited By ~ 4

Author(s):

Paul L. Rifkin ◽

Marjorie B. Zucker

Keyword(s):

Mechanism Of Action ◽

Human Blood ◽

Glass Bead ◽

Heart Valves ◽

Human Platelet ◽

Drug Effects ◽

Simple Relation ◽

Prosthetic Heart Valves ◽

Induced Aggregation

SummaryDipyridamole (Persantin) is reported to prolong platelet survival and inhibit embolism in patients with prosthetic heart valves, but its mechanism of action is unknown. Fifty jxM dipyridamole failed to reduce the high percentage of platelets retained when heparinized human blood was passed through a glass bead column, but prolonged the inhibition of retention caused by disturbing blood in vitro. Possibly the prostheses act like disturbance. Although RA 233 was as effective as dipyridamole in inhibiting the return of retention, it was less effective in preventing the uptake of adenosine into erythrocytes, and more active in inhibiting ADP-induced aggregation and release. Thus there is no simple relation between these drug effects.

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