MALT‐1 as a novel therapeutic target for adult T‐cell leukemia

2020 ◽  
Vol 105 (4) ◽  
pp. 460-467
Author(s):  
Chie Ishikawa ◽  
Naoki Mori
Keyword(s):  
T Cell ◽  
Therapeutic Target ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Novel Therapeutic

scholarly journals Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL)

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Xin Xu ◽  
Matko Kalac ◽  
Michael Markson ◽  
Mark Chan ◽  
Joshua D. Brody ◽  
...  
Keyword(s):  
T Cell ◽  
Therapeutic Approach ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Novel Therapeutic

scholarly journals Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma

Retrovirology ◽  
2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Daniel A. Rauch ◽  
Sydney L. Olson ◽  
John C. Harding ◽  
Hemalatha Sundaramoorthi ◽  
Youngsoo Kim ◽  
...  
Keyword(s):  
T Cell ◽  
Therapeutic Target ◽  
Interferon Regulatory Factor ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Regulatory Factor ◽  
Adult T Cell Leukemia ◽  
Interferon Regulatory Factor 4

scholarly journals Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T-cell leukemia

2017 ◽  
Vol 109 (1) ◽  
pp. 103-111 ◽  
Author(s):  
Takahito Kawata ◽  
Kohei Tada ◽  
Masayuki Kobayashi ◽  
Takashi Sakamoto ◽  
Yoko Takiuchi ◽  
...  
Keyword(s):  
T Cell ◽  
Signaling Pathways ◽  
Therapeutic Target ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Promising Therapeutic Target ◽  
Dual Inhibition

scholarly journals Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia

2017 ◽  
Vol 16 (7) ◽  
pp. 1401-1411 ◽  
Author(s):  
Jixin Ding ◽  
Melissa L. Fishel ◽  
April M. Reed ◽  
Erin McAdams ◽  
Magdalena B. Czader ◽  
...  
Keyword(s):  
T Cell ◽  
Therapeutic Target ◽  
Transcriptional Regulator ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Novel Therapeutic

scholarly journals Constitutive activation of Pim1 kinase is a therapeutic target for adult T-cell leukemia

Blood ◽  
2016 ◽  
Vol 127 (20) ◽  
pp. 2439-2450 ◽  
Author(s):  
Marcia Bellon ◽  
Ling Lu ◽  
Christophe Nicot
Keyword(s):  
T Cell ◽  
Therapeutic Target ◽  
Epigenetic Silencing ◽  
Kinase Signaling ◽  
Cell Leukemia ◽  
Constitutive Activation ◽  
Adult T Cell Leukemia ◽  
Pim1 Kinase ◽  
Key Points ◽  
Novel Therapeutic

Key Points Epigenetic silencing of miR-124a leads to constitutive STAT3 and activation of downstream Pim1. Pim1 kinase signaling is constitutively activated in ATL cells and represents a novel therapeutic target.

scholarly journals XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53-mediated caspase-dependent apoptosis

2021 ◽  
Vol 11 (2) ◽  
Author(s):  
Eline Boons ◽  
Tatiane C. Nogueira ◽  
Tim Dierckx ◽  
Soraya Maria Menezes ◽  
Maarten Jacquemyn ◽  
...  
Keyword(s):  
T Cell ◽  
Therapeutic Option ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Novel Therapeutic
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