scholarly journals Myocyte enhancer factor‐2 and p300 interact to regulate the expression of homeostatic regulator Pumilio in Drosophila

2019 ◽  
Author(s):  
Wei‐Hsiang Lin ◽  
Richard A. Baines
Keyword(s):  
Myocyte Enhancer Factor 2 ◽  
Myocyte Enhancer Factor ◽  
Enhancer Factor

Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2

2004 ◽  
Vol 127 (4) ◽  
pp. 1174-1188 ◽  
Author(s):  
Xuemin Wang ◽  
Xiaoli Tang ◽  
Xiaoming Gong ◽  
Efsevia Albanis ◽  
Scott L. Friedman ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Hepatic Stellate Cell ◽  
Cell Activation ◽  
Stellate Cell ◽  
Myocyte Enhancer Factor 2 ◽  
Hepatic Stellate Cell Activation ◽  
Myocyte Enhancer Factor ◽  
Enhancer Factor

scholarly journals Angiopoietin-1 Induces Krüppel-like Factor 2 Expression through a Phosphoinositide 3-Kinase/AKT-dependent Activation of Myocyte Enhancer Factor 2

2008 ◽  
Vol 284 (9) ◽  
pp. 5592-5601 ◽  
Author(s):  
Keisuke Sako ◽  
Shigetomo Fukuhara ◽  
Takashi Minami ◽  
Takao Hamakubo ◽  
Haihua Song ◽  
...  
Keyword(s):  
Myocyte Enhancer Factor 2 ◽  
Myocyte Enhancer Factor ◽  
Phosphoinositide 3 Kinase ◽  
Angiopoietin 1 ◽  
Enhancer Factor

scholarly journals Myocyte Enhancer Factor 2 and Class II Histone Deacetylases Control a Gender-Specific Pathway of Cardioprotection Mediated by the Estrogen Receptor

2010 ◽  
Vol 106 (1) ◽  
pp. 155-165 ◽  
Author(s):  
Eva van Rooij ◽  
Jens Fielitz ◽  
Lillian B. Sutherland ◽  
Victor L. Thijssen ◽  
Harry J. Crijns ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Histone Deacetylases ◽  
Class Ii ◽  
Myocyte Enhancer Factor 2 ◽  
Myocyte Enhancer Factor ◽  
Specific Pathway ◽  
Gender Specific ◽  
Enhancer Factor

scholarly journals Adult Myogenesis inDrosophila melanogasterCan Proceed Independently of Myocyte Enhancer Factor-2

Genetics ◽  
2005 ◽  
Vol 170 (4) ◽  
pp. 1747-1759 ◽  
Author(s):  
Phillip W. Baker ◽  
Kathleen K. Kelly Tanaka ◽  
Niels Klitgord ◽  
Richard M. Cripps
Keyword(s):  
Myocyte Enhancer Factor 2 ◽  
Myocyte Enhancer Factor ◽  
Enhancer Factor

scholarly journals Restoration of Impaired Endothelial Myocyte Enhancer Factor 2 Function Rescues Pulmonary Arterial Hypertension

Circulation ◽  
2015 ◽  
Vol 131 (2) ◽  
pp. 190-199 ◽  
Author(s):  
Jongmin Kim ◽  
Cheol Hwangbo ◽  
Xiaoyue Hu ◽  
Yujung Kang ◽  
Irinna Papangeli ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Myocyte Enhancer Factor 2 ◽  
Myocyte Enhancer Factor ◽  
Pulmonary Arterial ◽  
Enhancer Factor

scholarly journals Direct Interaction between Myocyte Enhancer Factor 2 (MEF2) and Protein Phosphatase 1α Represses MEF2-Dependent Gene Expression

2009 ◽  
Vol 29 (12) ◽  
pp. 3355-3366 ◽  
Author(s):  
R. L. S. Perry ◽  
C. Yang ◽  
N. Soora ◽  
J. Salma ◽  
M. Marback ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Protein Interactions ◽  
Protein Phosphatase ◽  
Hippocampal Neurons ◽  
Neuronal Cell ◽  
Direct Interaction ◽  
Myocyte Enhancer Factor 2 ◽  
Myocyte Enhancer Factor ◽  
Enhancer Factor

ABSTRACT The myocyte enhancer factor 2 (MEF2) transcription factors play important roles in neuronal, cardiac, and skeletal muscle tissues. MEF2 serves as a nuclear sensor, integrating signals from several signaling cascades through protein-protein interactions with kinases, chromatin remodeling factors, and other transcriptional regulators. Here, we report a novel interaction between the catalytic subunit of protein phosphatase 1α (PP1α) and MEF2. Interaction occurs within the nucleus, and binding of PP1α to MEF2 potently represses MEF2-dependent transcription. The interaction utilizes uncharacterized domains in both PP1α and MEF2, and PP1α phosphatase activity is not obligatory for MEF2 repression. Moreover, a MEF2-PP1α regulatory complex leads to nuclear retention and recruitment of histone deacetylase 4 to MEF2 transcription complexes. PP1α-mediated repression of MEF2 overrides the positive influence of calcineurin signaling, suggesting PP1α exerts a dominant level of control over MEF2 function. Indeed, PP1α-mediated repression of MEF2 function interferes with the prosurvival effect of MEF2 in primary hippocampal neurons. The PP1α-MEF2 interaction constitutes a potent locus of control for MEF2-dependent gene expression, having potentially important implications for neuronal cell survival, cardiac remodeling in disease, and terminal differentiation of vascular, cardiac, and skeletal muscle.

Sign in / Sign up

Export Citation Format

Share Document