A double‐blind sham‐controlled phase 1 clinical trial of tDCS of the dorsolateral prefrontal cortex in cocaine inpatients: Craving, sleepiness, and contemplation to change

Abstract Background/aim Opioid use disorder (OUD) can have negative impact on cognitive functions. This study aims to evaluate the effect of bilateral transcranial direct-current stimulation (tDCS) over the right/left dorsolateral prefrontal cortex (DLPFC) on the cognitive abilities of OUD men. Methods This study is a double-blind sham-controlled randomized clinical trial with a pretest/posttest design. Participants were 31 men with OUD living in Zanjan, Iran, assigned to three groups of left anode/right cathode tDCS, right anode/left cathode tDCS, and sham tDCS. The two active groups received tDCS (2 mA) at 10 sessions each for 10–20 min. The Cognitive Abilities Questionnaire (CAQ) in Persian was used to measure their cognitive abilities before and after intervention. Collected data were analyzed in SPSS v.22 software. Results Bilateral DLPFC stimulation resulted in a significant improvement in cognitive flexibility, planning, decision making, inhibitory control/selective attention, and memory of patients in the two active tDCS groups, while the sham tDCS had no significant effect on their cognitive abilities. Conclusion Bilateral tDCS over DLPFC, as an effective and complementary treatment, can improve the cognitive abilities of men with OUD. Trial registration: This study is a double-blind sham-controlled clinical trial (Parallel, IRCT20170513033946N5. Registered 19 Jan 2019, https://en.irct.ir/trial/36081).

Download Full-text

Safety and immunogenicity of a quadrivalent inactivated subunit non-adjuvanted influenza vaccine: A randomized, double-blind, active-controlled phase 1 clinical trial

Vaccine ◽

10.1016/j.vaccine.2021.05.070 ◽

2021 ◽

Author(s):

Yanxia Wang ◽

Yuhui Zhang ◽

Haofei Wu ◽

Lili Huang ◽

Hailong Yu ◽

...

Keyword(s):

Clinical Trial ◽

Influenza Vaccine ◽

Phase 1 ◽

Double Blind ◽

Phase 1 Clinical Trial

Download Full-text

Effect of anodal transcranial direct current stimulation at the right dorsolateral prefrontal cortex on the cognitive function in patients with mild cognitive impairment: comments on a randomized double-blind controlled trial

Archives of Physical Medicine and Rehabilitation ◽

10.1016/j.apmr.2021.08.023 ◽

2021 ◽

Author(s):

Anas R. Alashram ◽

Giuseppe Annino

Keyword(s):

Cognitive Impairment ◽

Prefrontal Cortex ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Direct Current ◽

Dorsolateral Prefrontal Cortex ◽

Controlled Trial ◽

Double Blind ◽

Dorsolateral Prefrontal ◽

The Right

Download Full-text

Safety and immunogenicity of a highly attenuated rVSVN4CT1-EBOVGP1 Ebola virus vaccine: a randomised, double-blind, placebo-controlled, phase 1 clinical trial

The Lancet Infectious Diseases ◽

10.1016/s1473-3099(19)30614-0 ◽

2020 ◽

Vol 20 (4) ◽

pp. 455-466 ◽

Cited By ~ 3

Author(s):

David K Clarke ◽

Rong Xu ◽

Demetrius Matassov ◽

Theresa E Latham ◽

Ayuko Ota-Setlik ◽

...

Keyword(s):

Clinical Trial ◽

Virus Vaccine ◽

Ebola Virus ◽

Phase 1 ◽

Double Blind ◽

Double Blind Placebo ◽

Phase 1 Clinical Trial

Download Full-text

Repeated stimulation of the dorsolateral-prefrontal cortex improves executive dysfunctions and craving in drug addiction: A randomized, double-blind, parallel-group study

Brain Stimulation ◽

10.1016/j.brs.2019.12.028 ◽

2020 ◽

Vol 13 (3) ◽

pp. 582-593 ◽

Cited By ~ 11

Author(s):

Jaber Alizadehgoradel ◽

Vahid Nejati ◽

Fariba Sadeghi Movahed ◽

Saeed Imani ◽

Mina Taherifard ◽

...

Keyword(s):

Prefrontal Cortex ◽

Drug Addiction ◽

Dorsolateral Prefrontal Cortex ◽

Double Blind ◽

Repeated Stimulation ◽

Parallel Group Study ◽

Parallel Group ◽

Dorsolateral Prefrontal ◽

Executive Dysfunctions ◽

Stimulation Of

Download Full-text

Antidepressant efficacy of high-frequency transcranial magnetic stimulation over the left dorsolateral prefrontal cortex in double-blind sham-controlled designs: a meta-analysis

Psychological Medicine ◽

10.1017/s0033291708003462 ◽

2008 ◽

Vol 39 (1) ◽

pp. 65-75 ◽

Cited By ~ 228

Author(s):

D. J. L. G. Schutter

Keyword(s):

Prefrontal Cortex ◽

Transcranial Magnetic Stimulation ◽

Effect Size ◽

High Frequency ◽

Magnetic Stimulation ◽

Dorsolateral Prefrontal Cortex ◽

Meta Analysis ◽

Double Blind ◽

Left Dlpfc ◽

Dorsolateral Prefrontal

BackgroundFor more than a decade high-frequency repetitive transcranial magnetic stimulation (rTMS) has been applied to the left dorsolateral prefrontal cortex (DLPFC) in search of an alternative treatment for depression. The aim of this study was to provide an update on its clinical efficacy by performing a meta-analysis involving double-blind sham-controlled studies.MethodA literature search was conducted in the databases PubMed and Web of Science in the period between January 1980 and November 2007 with the search terms ‘depression’ and ‘transcranial magnetic stimulation’. Thirty double-blind sham-controlled parallel studies with 1164 patients comparing the percentage change in depression scores from baseline to endpoint of activeversussham treatment were included. A random effects meta-analysis was performed to investigate the clinical efficacy of fast-frequency rTMS over the left DLPFC in depression.ResultsThe test for heterogeneity was not significant (QT=30.46,p=0.39). A significant overall weighted mean effect size,d=0.39 [95% confidence interval (CI) 0.25–0.54], for active treatment was observed (z=6.52,p<0.0001). Medication resistance and intensity of rTMS did not play a role in the effect size.ConclusionsThese findings show that high-frequency rTMS over the left DLPFC is superior to sham in the treatment of depression. The effect size is robust and comparable to at least a subset of commercially available antidepressant drug agents. Current limitations and future prospects are discussed.

Download Full-text