scholarly journals Inhibitory synapse loss and accumulation of amyloid beta in inhibitory presynaptic terminals in Alzheimer’s disease

2021 ◽  
Author(s):  
Hatice Kurucu ◽  
Martí Colom‐Cadena ◽  
Caitlin Davies ◽  
Lewis Wilkins ◽  
Declan King ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Inhibitory Synapse ◽  
Presynaptic Terminals ◽  
Synapse Loss

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

2002 ◽  
Vol 38 ◽  
pp. 37-49 ◽  
Author(s):  
Janelle Nunan ◽  
David H Small
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Alternative Pathway ◽  
Protein A ◽  
Proteolytic Processing ◽  
Gamma Secretase ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's disease. The alternative pathway, involving alpha-secretase, precludes amyloid-beta protein formation. In this review, we describe the progress that has been made in identifying the secretases and their potential as therapeutic targets in the treatment or prevention of Alzheimer's disease.

The distribution of amyloid beta protein deposition in the corpus striatum of patients with Alzheimer's disease

1997 ◽  
Vol 23 (4) ◽  
pp. 322-325 ◽  
Author(s):  
M. J. Brilliant ◽  
R. J. Elble ◽  
M. Ghobrial ◽  
R. G. Struble
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Corpus Striatum ◽  
Amyloid Beta Protein ◽  
Protein Deposition
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