scholarly journals Interobserver variation in the classification of thymic lesions including biopsies and resection specimens in an international digital microscopy panel

2020 ◽  
Vol 77 (5) ◽  
pp. 734-741
Author(s):  
Janina L Wolf ◽  
Francien Nederveen ◽  
Hans Blaauwgeers ◽  
Alexander Marx ◽  
Andrew G Nicholson ◽  
...  
Keyword(s):  
Interobserver Variation ◽  
Digital Microscopy

scholarly journals Classification of endonasal HHT lesions using digital microscopy

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
F. Haubner ◽  
A. Schneider ◽  
H. Schinke ◽  
M. Bertlich ◽  
B. G. Weiss ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Treatment Modalities ◽  
Hereditary Haemorrhagic Telangiectasia ◽  
Digital Microscopy ◽  
Digital Microscope ◽  
Lower Severity ◽  
Gender Specific Differences ◽  
Vegf Level

Abstract Background Recurrent spontaneous epistaxis is the most common clinical manifestation and the most debilitating symptom in hereditary haemorrhagic telangiectasia (HHT) patients. To this date, there exist only a classification of HHT patients by different genetic mutations. There is no standard classification for the mucocutaneous endonasal manifestations of HHT. The aim of the present study was to document the variety of endonasal HHT lesions using digital microscopy and to propose a clinical classification. Methods We recorded the endonasal HHT lesions of 28 patients using a digital microscope. We reconstructed the 3D images und videos recorded by digital microscope afterwards and classified the endonasal lesions of HHT in two classes: Grade A, presence of only flat telangiectasias in the mucosa level and Grade B, (additional) presence of raised berry or wart-like telangiectasia spots. We investigated also Haemoglobin level by routine laboratory procedures, plasma VEGF level by ELISA, Severity of epistaxis by epistaxis severity score (ESS) and quality of life by a linear visual analogue scale (VAS). Results We found a higher quality of life and a lower severity of epistaxis in Grade A patients in comparison to Grade B patients. No difference in plasma VEGF level and in Haemoglobin between Grad A patients and Grade B patients could be detected. Plasma VEGF levels showed no gender specific differences. It could also not be correlated to the extranasal manifestation. Conclusion The classification for endonasal manifestation of HHT proposed in this study indicates severity of epistaxis und quality of life. Digital microscopy with the ability of 3D reconstruction of images presents a useful tool for such classifications. The classification of endonasal HHT lesions using digital microscopy allows to evaluate the dynamic of HHT lesions in the course of time independent of examiner. This allows also to evaluate the efficacy of the different treatment modalities by dynamic of HHT lesions. Moreover digital microscopy is very beneficial in academic teaching of rare diseases.

scholarly journals Pattern-based classification of invasive endocervical adenocarcinoma, depth of invasion measurement and distinction from adenocarcinoma in situ: interobserver variation among gynecologic pathologists

2016 ◽  
Vol 29 (8) ◽  
pp. 879-892 ◽  
Author(s):  
Carlos Parra-Herran ◽  
Monica Taljaard ◽  
Bojana Djordjevic ◽  
M Carolina Reyes ◽  
Lauren Schwartz ◽  
...  
Keyword(s):  
Interobserver Variation ◽  
Adenocarcinoma In Situ ◽  
Depth Of Invasion ◽  
Endocervical Adenocarcinoma

scholarly journals Interobserver variation in the classification of tumor deposits in rectal cancer—is the use of histopathological characteristics the way to go?

2021 ◽  
Author(s):  
Nelleke P. M. Brouwer ◽  
A. C. Lord ◽  
M. Terlizzo ◽  
A. C. Bateman ◽  
N. P. West ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Lymph Node ◽  
Perineural Invasion ◽  
Interobserver Agreement ◽  
Binary Classification ◽  
Venous Invasion ◽  
Interobserver Variation ◽  
Node Metastases

Abstract The focus on lymph node metastases (LNM) as the most important prognostic marker in colorectal cancer (CRC) has been challenged by the finding that other types of locoregional spread, including tumor deposits (TDs), extramural venous invasion (EMVI), and perineural invasion (PNI), also have significant impact. However, there are concerns about interobserver variation when differentiating between these features. Therefore, this study analyzed interobserver agreement between pathologists when assessing routine tumor nodules based on TNM 8. Electronic slides of 50 tumor nodules that were not treated with neoadjuvant therapy were reviewed by 8 gastrointestinal pathologists. They were asked to classify each nodule as TD, LNM, EMVI, or PNI, and to list which histological discriminatory features were present. There was overall agreement of 73.5% (κ 0.38, 95%-CI 0.33–0.43) if a nodal versus non-nodal classification was used, and 52.2% (κ 0.27, 95%-CI 0.23–0.31) if EMVI and PNI were classified separately. The interobserver agreement varied significantly between discriminatory features from κ 0.64 (95%-CI 0.58–0.70) for roundness to κ 0.26 (95%-CI 0.12–0.41) for a lone arteriole sign, and the presence of discriminatory features did not always correlate with the final classification. Since extranodal pathways of spread are prognostically relevant, classification of tumor nodules is important. There is currently no evidence for the prognostic relevance of the origin of TD, and although some histopathological characteristics showed good interobserver agreement, these are often non-specific. To optimize interobserver agreement, we recommend a binary classification of nodal versus extranodal tumor nodules which is based on prognostic evidence and yields good overall agreement.

Interobserver variation in classification of malleolar fractures

2015 ◽  
Vol 44 (10) ◽  
pp. 1435-1439 ◽  
Author(s):  
S. M. Verhage ◽  
S. J. Rhemrev ◽  
S. B. Keizer ◽  
H. M. E. Quarles van Ufford ◽  
J. M. Hoogendoorn
Keyword(s):  
Interobserver Variation ◽  
Malleolar Fractures

Intra- and Interobserver Variation in the Use of the Vienna Classification of Crohnʼs Disease

2005 ◽  
Vol 11 (7) ◽  
pp. 657-661 ◽  
Author(s):  
Lene Riis ◽  
Pia Munkholm ◽  
Vibeke Binder ◽  
Lene Theil Skovgaard ◽  
Ebbe Langholz
Keyword(s):  
Interobserver Variation ◽  
Vienna Classification

scholarly journals Classification of Thymic Epithelial Neoplasms Is Still a Challenge to Thoracic Pathologists: A Reproducibility Study Using Digital Microscopy

2014 ◽  
Vol 138 (5) ◽  
pp. 658-663 ◽  
Author(s):  
Hangjun Wang ◽  
Camelia S. Sima ◽  
Mary Beth Beasley ◽  
Peter Illei ◽  
Anjali Saqi ◽  
...  
Keyword(s):  
Digital Microscopy ◽  
Reproducibility Study ◽  
Epithelial Neoplasms

scholarly journals Classification of endonasal hereditary haemorrhagic telangiectasia using digital microscopy

2021 ◽  
Author(s):  
F Kashani ◽  
A Schneider ◽  
H Schinke ◽  
M Bertlich ◽  
BG. Weiß ◽  
...  
Keyword(s):  
Hereditary Haemorrhagic Telangiectasia ◽  
Digital Microscopy

Water monitoring by means of digital microscopy identification and classification of microalgae

2021 ◽  
Author(s):  
Laura Barsanti ◽  
Lorenzo Birindelli ◽  
Paolo Gualtieri
Keyword(s):  
Water Monitoring ◽  
Digital Microscopy ◽  
Freshwater Microalgae ◽  
Diverse Groups

Marine and freshwater microalgae belong to taxonomically and morphologically diverse groups of organisms spanning many phyla with thousands of species. These organisms play an important role as indicators of water...

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