THE RENAL EXCRETION AND TUBULAR REABSORPTION OF CITRIC ACID IN RENAL TUBULAR ACIDOSIS

ABSTRACT During treatment with steroid hormones the tubular reabsorption of citric acid (cit.) increases, and the endogenous citric acid clearance is reduced. This is attributed to increased diffusion of citric acid from the tubular lumen to the renal tissue. With simultaneous administration of corticosteroids and anabolic steroids the tubular reabsorption of citric acid becomes normal. Steroid hormones block the renal synthesis of cit. and the renal utilization of cit. becomes identical with the amount of cit. reabsorbed in the tubules. Blockade of the synthesis of cit. is attributed to the inhibitory effect of steroid hormones on enzyme systems.

Download Full-text

THE RENAL METABOLISM OF CITRIC ACID IN RENAL TUBULAR ACIDOSIS

Acta Medica Scandinavica ◽

10.1111/j.0954-6820.1969.tb01457.x ◽

2009 ◽

Vol 186 (1-6) ◽

pp. 161-163 ◽

Cited By ~ 3

Author(s):

E. K. Brodwall ◽

A. Öyri ◽

K. Skåland

Keyword(s):

Citric Acid ◽

Renal Tubular Acidosis ◽

Renal Metabolism ◽

Renal Tubular

Download Full-text

The renal excretion of hydrogen ion in renal tubular acidosis

The American Journal of Medicine ◽

10.1016/0002-9343(60)90091-7 ◽

1960 ◽

Vol 29 (4) ◽

pp. 576-585 ◽

Cited By ~ 11

Author(s):

G.D. Webster ◽

E.J. Huth ◽

J.R. Elkinton ◽

R.A. McCance

Keyword(s):

Renal Tubular Acidosis ◽

Renal Excretion ◽

Hydrogen Ion ◽

Renal Tubular

Download Full-text

Renal Excretion of Ammonium in Renal Tubular Acidosis

The Tohoku Journal of Experimental Medicine ◽

10.1620/tjem.114.301 ◽

1974 ◽

Vol 114 (4) ◽

pp. 301-313

Author(s):

RYUJI SHIOJI ◽

YASUHIKO SASAKI ◽

YOTARO HURUKAWA ◽

HIROSHI SAITO ◽

YUICHI MICHIMATA ◽

...

Keyword(s):

Renal Tubular Acidosis ◽

Renal Excretion ◽

Renal Tubular

Download Full-text

The renal excretion of hydrogen ion in renal tubular acidosis

The American Journal of Medicine ◽

10.1016/0002-9343(60)90092-9 ◽

1960 ◽

Vol 29 (4) ◽

pp. 586-598 ◽

Cited By ~ 40

Author(s):

E.J. Huth ◽

G.D. Webster ◽

J.R. Elkinton

Keyword(s):

Renal Tubular Acidosis ◽

Renal Excretion ◽

Hydrogen Ion ◽

Renal Tubular

Download Full-text

THE CONTROL OF THE RENAL EXCRETION OF WATER

Journal of Experimental Medicine ◽

10.1084/jem.76.4.387 ◽

1942 ◽

Vol 76 (4) ◽

pp. 387-399 ◽

Cited By ~ 111

Author(s):

James A. Shannon

Keyword(s):

Experimental Data ◽

Diabetes Insipidus ◽

Antidiuretic Hormone ◽

Intravenous Infusion ◽

Renal Excretion ◽

Tubular Reabsorption ◽

Posterior Pituitary ◽

Hormone Administration ◽

Renal Tubular Reabsorption ◽

Renal Tubular

1. The administration of the posterior pituitary antidiuretic hormone by constant intravenous infusion has been used to examine the two characteristic actions of the hormone; namely, the facilitation of the active renal tubular reabsorption of water distally in the nephron and the inhibition of the renal tubular reabsorption of sodium proximally. 2. Experimental evidence was obtained which indicates that variations in the excretion of water and electrolyte involve the integration of these two actions with obscure variables which are discemible in the experimental data but are not subject to definition at this time. 3. Graded antidiuresis in the animal with diabetes insipidus, when normally hydrated, was only obtained in the range of 0.001 to 0.005 unit (pressor) per hour. This range of hormone administration was also found to be physiologically active in the normal animals. These observations together with others permit the placing of the normal rate of liberation of the antidiuretic hormone in a10 to 15 kilo dog in the range of 0.001 to 0.005 unit per hour.

Download Full-text

Renal Excretion of Radioiodide in the Dog

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1956.187.3.529 ◽

1956 ◽

Vol 187 (3) ◽

pp. 529-535 ◽

Cited By ~ 9

Author(s):

Gerhard Giebisch ◽

Martha B. MacLeod ◽

Frederic Kavaler

Keyword(s):

Renal Excretion ◽

Indirect Evidence ◽

Tubular Reabsorption ◽

Water Reabsorption ◽

Water Diuresis ◽

Osmotic Diuresis ◽

Sodium Salts ◽

Nonspecific Effects ◽

Renal Tubular Reabsorption ◽

Renal Tubular

Radioiodide and creatinine clearances were measured simultaneously in dogs. Osmotic diuresis was induced by loading with mannitol, sodium salts of various anions such as chloride, bromide, iodide, nitrate and ferrocyanide, and by the administration of mercurial diuretics. Results of these experiments are compared with those obtained during water diuresis. No evidence for active tubular reabsorption of radioiodide could be observed. Renal tubular reabsorption of I131 was found to be chiefly determined by the degree of tubular water reabsorption and hence the transtubular diffusion gradient of radioiodide. Nonspecific effects of other anions in the tubular urine may modify passive tubular reabsorption: anions less readily reabsorbed displace I131 from the urine and depress its renal clearance. Indirect evidence suggests that about 95% of filtered radioiodide is reabsorbed at a tubular site proximal to that of final water reabsorption.

Download Full-text

CORRELATION BETWEEN ANTIDIURETIC HORMONE EFFECT AND THE RENAL EXCRETION OF MAGNESIUM AND CALCIUM IN MAN

Acta Endocrinologica ◽

10.1530/acta.0.0450151 ◽

1964 ◽

Vol 45 (1) ◽

pp. 151-160 ◽

Cited By ~ 14

Author(s):

Bent Nielsen

Keyword(s):

Antidiuretic Hormone ◽

Arginine Vasopressin ◽

Renal Excretion ◽

Normal Subjects ◽

Inhibitory Effect ◽

Tubular Reabsorption ◽

Hormone Effect ◽

Renal Tubular Reabsorption ◽

Renal Tubular ◽

Most Probable Explanation

ABSTRACT The effect of injection of physiological doses of commercial preparations of lysine- or arginine-vasopressin on the renal excretion of magnesium and calcium was studied in 20 hydrated normal subjects. In the majority of the experiments the injections were followed by a rise in the rate of excretion of magnesium as well as of calcium. In 3 subjects endogenously induced antidiuresis produced similar effects. In 1 case no changes were revealed during antidiuresis. The most probable explanation of these results would seem to be that the antidiuretic hormone exerts an inhibitory effect on the renal tubular reabsorption of magnesium and calcium.

Download Full-text