THE ACTION OF CORTICOSTEROIDS ON THE RENAL EXCRETION AND UTILIZATION OF CITRIC ACID
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ABSTRACT During treatment with steroid hormones the tubular reabsorption of citric acid (cit.) increases, and the endogenous citric acid clearance is reduced. This is attributed to increased diffusion of citric acid from the tubular lumen to the renal tissue. With simultaneous administration of corticosteroids and anabolic steroids the tubular reabsorption of citric acid becomes normal. Steroid hormones block the renal synthesis of cit. and the renal utilization of cit. becomes identical with the amount of cit. reabsorbed in the tubules. Blockade of the synthesis of cit. is attributed to the inhibitory effect of steroid hormones on enzyme systems.
2009 ◽
Vol 192
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pp. 137-139
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1994 ◽
Vol 267
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pp. R1454-R1460
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1979 ◽
Vol 25
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pp. 870-876
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1960 ◽
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pp. 829-832
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1975 ◽
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pp. 1745-1749
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pp. 54-57
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1995 ◽
Vol 79
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pp. 1082-1087
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1958 ◽
Vol 41
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pp. 737-753
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