scholarly journals Suboptimal thermoregulation in male adders (Vipera berus) after hibernation imposed by spermiogenesis

2007 ◽  
Vol 92 (1) ◽  
pp. 19-27 ◽  
Author(s):  
GÁBOR HERCZEG ◽  
JARMO SAARIKIVI ◽  
ABIGÉL GONDA ◽  
JARMO PERÄLÄ ◽  
AINO TUOMOLA ◽  
...  
Keyword(s):  
Toxins ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 279
Author(s):  
Tihana Kurtović ◽  
Svjetlana Karabuva ◽  
Damjan Grenc ◽  
Mojca Dobaja Borak ◽  
Igor Križaj ◽  
...  

Vipera ammodytes (V. ammodytes) is the most venomous European viper. The aim of this study was to compare the clinical efficacy and pharmacokinetic values of intravenous Vipera berus venom-specific (paraspecific) Fab fragments (ViperaTAb) and intramuscular V. ammodytes venom-specific F(ab’)2 fragments (European viper venom antiserum, also called “Zagreb” antivenom) in V.ammodytes-envenomed patients. This was a prospective study of V.ammodytes-envenomed patients that were treated intravenously with ViperaTAb or intramuscularly with European viper venom antiserum that was feasible only due to the unique situation of an antivenom shortage. The highest venom concentration, survival, length of hospital stay and adverse reactions did not differ between the groups. Patients treated with intravenous Fab fragments were sicker, with significantly more rhabdomyolysis and neurotoxicity. The kinetics of Fab fragments after one or more intravenous applications matched better with the venom concentration in the early phase of envenomation compared to F(ab’)2 fragments that were given intramuscularly only on admission. F(ab’)2 fragments given intramuscularly had 25-fold longer apparent total body clearance and 14-fold longer elimination half-time compared to Fab fragments given intravenously (2 weeks vs. 24 h, respectively). In V.ammodytes-envenomed patients, the intramuscular use of specific F(ab’)2 fragments resulted in a slow rise of antivenom serum concentration that demanded their early administration but without the need for additional doses for complete resolution of all clinical signs of envenomation. Intravenous use of paraspecific Fab fragments resulted in the immediate rise of antivenom serum concentration that enabled their use according to the clinical progress, but multiple doses might be needed for efficient therapy of thrombocytopenia due to venom recurrence, while the progression of rhabdomyolysis and neurotoxic effects of the venom could not be prevented.


2021 ◽  
pp. 1-10
Author(s):  
Thomas Lamb ◽  
David Stewart ◽  
David A. Warrell ◽  
David G. Lalloo ◽  
Pardeep Jagpal ◽  
...  
Keyword(s):  

2011 ◽  
Vol 32 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Tamás Malina ◽  
László Krecsák ◽  
Dušan Jelić ◽  
Tomislav Maretić ◽  
Tamás Tóth ◽  
...  

Toxicon ◽  
2010 ◽  
Vol 56 (8) ◽  
pp. 1510-1515 ◽  
Author(s):  
Alexander Westerström ◽  
Boyan Petrov ◽  
Nikolay Tzankov

1966 ◽  
Vol 4 (17) ◽  
pp. 65-66

The adder, Vipera berus, is a short grey snake with bold black V-shaped marks on its back, and is the only venomous snake found in Britain. In England and Wales the adder may be confused with the larger but venomless grass snake; Ireland, the Channel Islands and the Isle of Man are snake-free. Imported foreign venomous snakes are sometimes mistaken for adders; their bites usually require different treatment. Adders may abound in rocky or dry country, but are sometimes seen in residential areas. If disturbed, an adder may bite with its twin hollow fangs, from which the venom flows. The Ministry of Health no longer lists envenomation separately as a cause of admission to hospital, but Morton1 saw 18 cases during 8 years as an area pathologist in Cornwall and Walker2 recorded 50 cases and 7 deaths up to 1945. In 1961 about 400 requests for Pasteur Institute antivenom were made.3


2017 ◽  
Vol 38 (2) ◽  
pp. 133-144 ◽  
Author(s):  
Martin Ivanov ◽  
Andrej Čerňanský

Completely preserved specimens of fossil snakes are extremely rare and ophidian palaeontologists are usually dependent only on disarticulated elements of a postcranial skeleton. Here we present an unusually well-preserved specimen of a small viperid snake from the Late Pleistocene firm travertine at the famous Gánovce-Hrádok Neanderthal mound in Slovakia. The complex study of both cranial and axial skeleton with well-preserved maxilla and basiparasphenoid confirms the presence of a viper from theVipera berusspecies group, and recent distribution ofV. berusspecies complex members supports identification of these preserved remains as belonging to the common adder,V. berus(Linnaeus, 1758). Associated faunal assemblages of the MFG-C and D mammalian fauna groups reported from the firm travertine indicate a humid climate in a predominantly woodland environment with typical forest species in the Gánovce-Hrádok vicinity throughout the Eemian optimum, and mixed forest and steppe environments in the late Eemian to early Weichselian stages. Occurrence ofV. berusdocuments the presence of open or semi-open biotopes with low vegetation. AlthoughV. berusoccurs in the Quaternary glacial/interglacial cycle and throughout the entire warm part, it never dominated herpetofaunal assemblages during the climatic optimum. Therefore, the presence ofV. berusmost likely indicates late Eemian or early Weichselian (interstadial) climatic conditions.


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