Outcome after admission to ITU following out-of-hospital cardiac arrest: are non-survivors suitable for non-heart-beating organ donation?

Anaesthesia ◽  
2007 ◽  
Vol 62 (5) ◽  
pp. 434-437 ◽  
Author(s):  
Andrew P. Gratrix ◽  
Alison J. Pittard ◽  
Andrew R. Bodenham
Author(s):  
Jonathan Elmer ◽  
Amy R. Weisgerber ◽  
David J. Wallace ◽  
Edward Horne ◽  
Susan A Stuart ◽  
...  

1999 ◽  
Vol 27 (2) ◽  
pp. 126-136 ◽  
Author(s):  
James M. DuBois

The family of a patient who is unconscious and respirator-dependent has made a decision to discontinue medical treatment. The patient had signed a donor card. The family wants to respect this decision, and agrees to non-heart-beating organ donation. Consequently, as the patient is weaned from the ventilator, he is prepped for organ explantation. Two minutes after the patient goes into cardiac arrest, he is declared dead and the transplant team arrives to begin organ procurement. At the time retrieval begins, it is not certain that the patient's brain is dead or that cardiac function cannot be restored. Procurement follows uneventfully, and two transplantable kidneys are retrieved.Many people now consider such cases of non-heart-beating organ donation to be ethically permissible. However, widespread disagreement persists as to how such practices are to be justified and whether such practices are compatible with the Uniform Declaration of Death Act (UDDA). In this paper, I argue that non-heart-beating organ donation can be ethically justified, that in the justified cases the patients are in fact dead, and that the early declarations of death required for such donation do comply with the UDDA.


Resuscitation ◽  
2016 ◽  
Vol 101 ◽  
pp. 41-43 ◽  
Author(s):  
Olivia V. Cheetham ◽  
Matthew J.C. Thomas ◽  
John Hadfield ◽  
Fran O’Higgins ◽  
Claire Mitchell ◽  
...  

Author(s):  
Mohamed Y. Rady ◽  
Ari R. Joffe

The transplantation community endorses controlled and uncontrolled non-heart-beating organ donation (NHBD) to increase the supply of transplantable organs at end of life. Cardiac arrest must occur within 1–2 hours after the withdrawal of life-support in controlled NHBD. Uncontrolled NHBD is performed after failed cardiopulmonary resuscitation in an unexpected witnessed cardiac arrest. Donor management aims to protect transplantable organs against warm ischaemic injury through the optimization of haemodynamics and mechanical ventilation. This also requires antemortem instrumentation and systemic anticoagulation for organ perseveration in controlled NHBD. Interval support with extracorporeal membrane oxygenation or cardiopulmonary bypass is generally required for optimal organ perfusion and oxygenation in uncontrolled NHBD, which remains a controversial medical practice. There are several unresolved ethical challenges. The circulatory criterion of 2–10 minutes of absent arterial pulse does not comply with the uniform determination of death criterion of the irreversible cessation of functions of the cardiovascular or central nervous systems. There are no robust safeguards in clinical practice that can prevent faulty prognostication, and premature withdrawal of treatment or termination of cardiopulmonary resuscitation. Unmanaged conflicting interests of increasing the supply of transplantable organs can have serious consequences on the medical care of potentially salvageable patients. Perimortem interventions can interfere with the delivery of an optimal quality of end-of-life care. The lack of disclosure of these NHBD ethical controversies does not uphold the moral obligation for an informed consent.


2017 ◽  
Vol 166 (8) ◽  
pp. 608
Author(s):  
Joséphine Escutnaire ◽  
Hervé Hubert ◽  
Pierre-Yves Dubien ◽  
Pierre-Yves Gueugniaud

2017 ◽  
Vol 166 (8) ◽  
pp. 608
Author(s):  
Nicole Karam ◽  
Patricia Jabre ◽  
Florence Dumas ◽  
Alain Cariou ◽  
Xavier Jouven

2012 ◽  
Vol 30 (3) ◽  
pp. 226-231 ◽  
Author(s):  
Caroline M Bruce ◽  
Matthew James Reed ◽  
Margaret MacDougall

Anaesthesia ◽  
2007 ◽  
Vol 62 (11) ◽  
pp. 1185-1186 ◽  
Author(s):  
M. A. Kuiper ◽  
A. E. Schaafsma ◽  
M. J. Van Dam ◽  
M. J. Schultz ◽  
P. E. Spronk

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