Aberrant human tissue kallikrein levels in the stratum corneum and serum of patients with psoriasis: dependence on phenotype, severity and therapy

2007 ◽  
Vol 156 (5) ◽  
pp. 875-883 ◽  
Author(s):  
N. Komatsu ◽  
K. Saijoh ◽  
C. Kuk ◽  
F. Shirasaki ◽  
K. Takehara ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Human Tissue ◽  
Tissue Kallikrein

Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer

2009 ◽  
Vol 101 (04) ◽  
pp. 741-747 ◽  
Author(s):  
Konstantina Mathioudaki ◽  
Panagiotis Prezas ◽  
Dimitra Alexopoulou ◽  
Eleftherios Diamandis ◽  
Dimitris Xynopoulos ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Stratum Corneum ◽  
Human Tissue ◽  
Serine Proteases ◽  
Human Cancer ◽  
Disease Free Survival ◽  
Normal Colonic Mucosa ◽  
Tissue Kallikrein ◽  
Human Cancer Cell Lines

SummaryHuman tissue kallikrein-related peptidases are a family of 15 secreted serine proteases, located at chromosome 19q13.4. Most of them have been reported to be potential biomarkers for several carcinomas and other diseases. Human tissue kallikrein-related peptidase 7 (KLK7) has been purified from human stratum corneum and resembles a chymotryptic endopeptidase originally called stratum corneum chymotryptic enzyme (SCCE). In this study, we examined for the first time, the prognostic value of KLK7 mRNA expression, using a semi-quantitative RT-PCR method, in 105 colorectal cancer tissues for 54 of which, paired normal colonic mucosa were available. Furthermore, we analysed the expression of KLK7 in 10 adenomas, in 18 biopsies of inflamed colon mucosa, as well as in 22 human cancer cell lines of various origin, four of them being of colon. A defined number of colon cancer samples were also examined by immunohisto-chemistry. KLK7 expression was higher in cancerous than in normal tissues. Less differentiated tumors of more advanced stage showed higher KLK7 expression. Follow-up analysis revealed that KLK7 was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). In addition, selected colon cancer samples highly expressing KLK7 gene, showed intense immunohistochemical staining for KLK7, enhancing RTPCR results. Present data suggest that KLK7 gene is up-regulated in colon cancer and its expression predicts poor prognosis for colon cancer patients.

Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients

2007 ◽  
Vol 16 (6) ◽  
pp. 513-519 ◽  
Author(s):  
Nahoko Komatsu ◽  
Kiyofumi Saijoh ◽  
Cynthia Kuk ◽  
Amber C. Liu ◽  
Saba Khan ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Stratum Corneum ◽  
Human Tissue ◽  
Tissue Kallikrein

scholarly journals Elevated Human Tissue Kallikrein Levels in the Stratum Corneum and Serum of Peeling Skin Syndrome-Type B Patients Suggests an Over-desquamation of Corneocytes

2006 ◽  
Vol 126 (10) ◽  
pp. 2338-2342 ◽  
Author(s):  
Nahoko Komatsu ◽  
Yasushi Suga ◽  
Kiyofumi Saijoh ◽  
Amber C. Liu ◽  
Saba Khan ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Human Tissue ◽  
Tissue Kallikrein ◽  
Syndrome Type ◽  
Type B

Human Tissue Kallikrein: A New Bullet for the Treatment of Ischemia

2003 ◽  
Vol 9 (7) ◽  
pp. 589-597 ◽  
Author(s):  
Costanza Emanueli ◽  
Paolo Madeddu
Keyword(s):  
Human Tissue ◽  
Tissue Kallikrein

scholarly journals Specificity of human tissue kallikrein towards substrates containing Phe‒Phe pair of amino acids

1999 ◽  
Vol 339 (2) ◽  
pp. 473 ◽  
Author(s):  
Daniel C. PIMENTA ◽  
Julie CHAO ◽  
Lee CHAO ◽  
Maria A. JULIANO ◽  
Luiz JULIANO
Keyword(s):  
Amino Acids ◽  
Human Tissue ◽  
Tissue Kallikrein

scholarly journals Human tissue kallikrein 1 ameliorates erectile function via modulation of macroautophagy in aged transgenic rats

Andrology ◽  
2018 ◽  
Vol 6 (5) ◽  
pp. 766-774 ◽  
Author(s):  
Z. Tang ◽  
K. Cui ◽  
Y. Luan ◽  
Y. Ruan ◽  
T. Wang ◽  
...  
Keyword(s):  
Human Tissue ◽  
Erectile Function ◽  
Tissue Kallikrein ◽  
Transgenic Rats
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