The Relation between Morphology and Other Features of Acute Myeloid Leukaemia, and their Prognostic Significance: Report of the Medical Research Council's Working Party on Leukaemia in Adults

1975 ◽  
Vol 31 (s1) ◽  
pp. 165-180 ◽  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Medical Research ◽  
Myeloid Leukaemia ◽  
Prognostic Significance ◽  
Working Party ◽  
Acute Myeloid

scholarly journals Expression and prognostic significance of survivin in de novo acute myeloid leukaemia

2000 ◽  
Vol 111 (1) ◽  
pp. 196-203 ◽  
Author(s):  
Colette Adida ◽  
Christian Recher ◽  
Emmanuel Raffoux ◽  
Marie-Thérèse Daniel ◽  
Anne-Laure Taksin ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
De Novo ◽  
Prognostic Significance ◽  
Acute Myeloid

scholarly journals The Clinical Features and Prognosis of NPM1/FLT3-ITD/DNMT3A Triple-mutated Acute Myeloid Leukaemia

2021 ◽  
Author(s):  
Xingchun Luo ◽  
Bei Liu ◽  
Haiping Liang ◽  
Long Zhao ◽  
Yuancheng Guo ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Bioinformatics Analysis ◽  
De Novo ◽  
Prognostic Significance ◽  
Gene Expression Omnibus ◽  
Prognostic Impact ◽  
Newly Diagnosed ◽  
De Novo Aml ◽  
Acute Myeloid

Abstract Purpose: Previous studies have shown that patients with NPM1+/FLT3-ITD+ acute myeloid leukaemia (AML) have a poor prognosis, especially those with a high FLT3-ITD allelic ratio. However, no studies have confirmed a clear prognostic impact of DNMT3A on NPM1+/FLT3-ITD+ AML patients. Methods: Our study included a total of 165 patients with newly diagnosed non-acute promyelocytic leukaemia (non-APL) AML at The First Hospital of Lanzhou University between January 2018 and June 2021. Further bioinformatics analysis was performed using the Gene Expression Omnibus (GEO) database. Results: We retrospectively studied 165 patients newly diagnosed non-APL AML and identified 11 (6.7%) patients with NPM1/FLT3-ITD/DNMT3A triple mutations. The patients with triple-mutated AML had advanced age, higher white blood cell (WBC) counts, de novo AML, normal karyotypes, and poor survival, and all were in the M4/M5 French-American-British (FAB) category. Notably, half of the patients with triple-mutated AML had mature monocyte characteristics that were difficult to distinguish from chronic myelomonocytic leukaemia (CMML). We validated the prognosis of patients with triple-mutated AML by further bioinformatics analysis and found that the GNG4 gene, one of the hub genes, was related to triple-mutated AML patients' survival. Conclusion: Our data demonstrate that DNMT3A gene mutation has adverse prognostic significance in NPM1+FLT3-ITD+comutation AML patients.

scholarly journals Results of a randomized trial in children with Acute Myeloid Leukaemia: Medical Research Council AML12 trial

2011 ◽  
Vol 155 (3) ◽  
pp. 366-376 ◽  
Author(s):  
Brenda E. S. Gibson ◽  
David K. H. Webb ◽  
Andrew J. Howman ◽  
Siebold S. N. De Graaf ◽  
Christine J. Harrison ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Medical Research ◽  
Randomized Trial ◽  
Myeloid Leukaemia ◽  
Research Council ◽  
Medical Research Council ◽  
Acute Myeloid
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