Tryptase and histamine release due to a sting challenge in bee venom allergic patients treated successfully or unsuccessfully with hyposensitization *

1995 ◽  
Vol 25 (8) ◽  
pp. 704-712 ◽  
Author(s):  
B. EBERLEIN-KONIG ◽  
S. ULLMANN ◽  
P. THOMAS ◽  
B. PRZYBILLA
Keyword(s):  
Histamine Release ◽  
Bee Venom ◽  
Sting Challenge

Evaluation and validation of a bee venom sting challenge performed by a micro-syringe

2012 ◽  
Vol 109 (6) ◽  
pp. 438-441 ◽  
Author(s):  
Gabriele Cortellini ◽  
Maurizio Severino ◽  
Elisabetta Francescato ◽  
Stefano Turillazzi ◽  
Igino Spadolini ◽  
...  
Keyword(s):  
Bee Venom ◽  
Sting Challenge

scholarly journals Honey Bee Venom Re-Challenge During Specific Immunotherapy: Prolonged Cardio-Pulmonary Resuscitation Allowed Survival in a Case of Near Fatal Anaphylaxis

2021 ◽  
Author(s):  
Sara Micaletto ◽  
Kurt Ruetzler ◽  
Martin Bruesch ◽  
Peter Schmid-Grendelmeier
Keyword(s):  
Honey Bee ◽  
Specific Immunotherapy ◽  
Time Span ◽  
Bee Venom ◽  
Bee Sting ◽  
Cardio Pulmonary Resuscitation ◽  
Risk Patients ◽  
Cardio Vascular ◽  
Sting Challenge ◽  
Fatal Anaphylaxis

Abstract BACKGROUND Specific immunotherapy for patients with honey bee hypersensitivity is commonly applied. Re-challenge with venom is performed to prove protection.CASE PRESENATION We report a case of near fatal anaphylaxis with asystolia for 24 minutes in a 35-years-old patient with mastocytosis after honey bee sting challenge despite 5-years of specific immunotherapy. Successful cardio-pulmonary resuscitation (CPR) was applied for 32 minutes.CONCLUSION This intervention demonstrates, that in anaphylaxis with cardio-vascular arrest prolonged CPR for up to 40 minutes might be appropriate to overcome half time span of massively released histamine. Failure of specific immunotherapy was possibly due to sensitization to the allergen Api m10, probably underrepresented in commercial honey bee venom extracts. Also, molecular analyses might alert to potential unsuccessful outcome of venom specific immunotherapy especially in high-risk patients such as mastocytosis.

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