Comparison of serum cardiac specific troponin-I with creatine kinase, creatine kinase-MB isoenzyme, tropomyosin, myoglobin and C-reactive protein release in marathon runners: cardiac or skeletal muscle trauma?

1987 ◽  
Vol 17 (4) ◽  
pp. 317-324 ◽  
Author(s):  
P. CUMMINS ◽  
A. YOUNG ◽  
M. L. AUCKLAND ◽  
C. A. MICHIE ◽  
P. C. W. STONE ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Troponin I ◽  
Protein Release ◽  
C Reactive Protein ◽  
Marathon Runners ◽  
Reactive Protein ◽  
Muscle Trauma ◽  
Creatine Kinase Mb

Skeletal muscle trauma and creatine kinase MB

1987 ◽  
Vol 5 (5) ◽  
pp. 469-472 ◽  
Author(s):  
Joyce G. Schwartz ◽  
Carole L. Gage ◽  
Margaret L. Darnell ◽  
Tom Prihoda
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Muscle Trauma ◽  
Creatine Kinase Mb

Creatine kinase-MB isoenzyme adaptations in stressed human skeletal muscle of marathon runners

1985 ◽  
Vol 59 (1) ◽  
pp. 149-153 ◽  
Author(s):  
F. S. Apple ◽  
M. A. Rogers ◽  
D. C. Casal ◽  
W. M. Sherman ◽  
J. L. Ivy
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Gastrocnemius Muscle ◽  
Acute Exercise ◽  
Elevated Serum ◽  
Long Distance ◽  
Marathon Runners ◽  
Creatine Kinase Mb ◽  
Isoenzyme Composition ◽  
Muscle Biopsies

The creatine kinase (CK) isoenzyme composition was determined in serial gastrocnemius muscle biopsies obtained from 12 male marathon runners. The mean muscle CK-MB composition significantly increased after chronic exercise (training) from 5.3% (pretraining) to 7.7% (premarathon) as well as after acute exercise (postmarathon) to 10.5% of the total CK activity (P less than 0.05). However, no significant differences in total CK activities were detected. Additionally, mitochondrial CK and CK-BB isoenzymes were present in muscle homogenates. A significant correlation was observed in the increase in mean serum total CK (3,322 U/l) and CK-MB (174 U/l) activities 24 h after the race (r = 0.98, P less than 0.05). These results show that gastrocnemius muscle adapts to long-distance training and racing with increased CK-MB activities and imply that skeletal muscle is the major source of elevated serum CK-MB activities in marathon runners.

scholarly journals Fast skeletal troponin I, but not the slow isoform, is increased in patients under statin therapy: a pilot study

2018 ◽  
Vol 29 (1) ◽  
pp. 68-76
Author(s):  
Alessandro Trentini ◽  
Maria C Manfrinato ◽  
Tiziana Bellini ◽  
Carlo A Volta ◽  
Stefania Hanau ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Statin Therapy ◽  
Muscle Damage ◽  
Troponin I ◽  
Academic Hospital ◽  
Creatine Kinase Mb ◽  
The University ◽  
Fast Twitch ◽  
Muscular Damage

Introduction: Statin therapy is often associated with muscle complaints and increased serum creatine kinase (CK). However, although essential in determining muscle damage, this marker is not specific for skeletal muscle. Recent studies on animal models have shown that slow and fast isoforms of skeletal troponin I (ssTnI and fsTnI, respectively) can be useful markers of skeletal muscle injury. The aim of this study was to evaluate the utility of ssTnI and fsTnI as markers to monitor the statin-induced skeletal muscle damage. Materials and methods: A total of 51 patients (14 using and 37 not using statins) admitted to the intensive care unit of the University of Ferrara Academic Hospital were included in this observational study. Serum activities of CK, aldolase, alanine aminotransferase and myoglobin were determined by spectrophotometric assays or routine laboratory analysis. Isoforms ssTnI and fsTnI were determined by commercially available ELISAs. The creatine kinase MB isoform (CK-MB) and cardiac troponin I (cTnI) were evaluated as biomarkers of cardiac muscle damage by automatic analysers. Results: Among the non-specific markers, only CK was significantly higher in statin users (P = 0.027). Isoform fsTnI, but not ssTnI, was specifically increased in those patients using statins (P = 0.009) evidencing the major susceptibility of fast-twitch fibres towards statins. Sub-clinical increase in fsTnI, but not CK, was more frequent in statin users (P = 0.007). Cardiac markers were not significantly altered by statins confirming the selectivity of the effect on skeletal muscle. Conclusions: Serum fsTnI could be a good marker for monitoring statin-associated muscular damage outperforming traditional markers.

Creatine kinase MB in cases of skeletal muscle trauma.

1988 ◽  
Vol 34 (5) ◽  
pp. 898-901 ◽  
Author(s):  
J G Schwartz ◽  
T J Prihoda ◽  
J H Stuckey ◽  
C L Gage ◽  
M L Darnell
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Muscle Injury ◽  
Myocardial Injury ◽  
Skeletal Muscle Injury ◽  
Negative Results ◽  
Muscle Trauma ◽  
Creatine Kinase Mb ◽  
Cardiac Status ◽  
Creatine Kinase Isoenzyme Mb

Abstract Fifty-eight patients admitted through our emergency room with severe skeletal muscle injury but no obvious cardiac contusions were evaluated for creatine kinase isoenzyme MB (CK-MB). When such patients show an above-normal value for total CK, it is a question of whether or not myocardial injury has been sustained along with skeletal muscle injury when (a) there are no obvious chest contusions or (b) the patient is unconscious and unable to complain of chest pain. Whenever there is doubt concerning the cardiac status of a patient, lactate dehydrogenase (LD) isoenzymes, serial electrocardiograms, and CK isoenzymes are ordered. Our study revealed that serum of 8.6% of the trauma victims had CK-MB values exceeding 5.0 EU/L (reflecting abnormal CK-MB concentrations) as part of their increased total CK. All patients had normal electrocardiographic patterns along with negative results for LD isoenzymes; none had sustained any demonstrable myocardial injury. The CK-MB value must be interpreted together with the total CK value for appropriate diagnosis in patients with skeletal muscle trauma.

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