6-Hydroxydopamine Lesions of the Locus Coeruleus Induce a Paradoxical Increase in Growth Hormone Secretion in Male Rats

SUMMARY A single 12 mg dose of stilboestrol dipropionate given to 100-day-old male rats resulted in increased pituitary mitotic activity, pituitary weight and serum growth hormone; the latter rose from a mean value of 20 ng/ml to a maximum of 342 ng/ml 9 days later. Serum growth hormone and pituitary mitotic activity then gradually diminished but were still slightly increased on day 28. Serum growth hormone and pituitary weight were significantly correlated during the periods of rapidly rising and of sustained high levels of serum growth hormone. Indices of mitotic activity were correlated with serum growth hormone during the periods of rapidly rising and of falling levels of serum growth hormone.

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Effect of intermittent infusions of somatostatin on growth hormone secretion in unrestrained male rats with hypothalamic deafferentation

Brain Research ◽

10.1016/0006-8993(90)90554-o ◽

1990 ◽

Vol 509 (2) ◽

pp. 293-298 ◽

Cited By ~ 4

Author(s):

Shiro Minami ◽

Ichiji Wakabayashi ◽

Hitoshi Sugihara ◽

Jun Kamegai ◽

Osamu Hasegawa ◽

...

Keyword(s):

Growth Hormone ◽

Hormone Secretion ◽

Growth Hormone Secretion ◽

Male Rats ◽

Hypothalamic Deafferentation

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Positive role of non-N-methyl-D-aspartate receptors in the control of growth hormone secretion in male rats

Journal of Endocrinological Investigation ◽

10.1007/bf03344969 ◽

1996 ◽

Vol 19 (6) ◽

pp. 353-358 ◽

Cited By ~ 4

Author(s):

L. Pinilla ◽

M. Tena-Sempere ◽

D. Gonzalez ◽

E. Aguilar

Keyword(s):

Growth Hormone ◽

Hormone Secretion ◽

Growth Hormone Secretion ◽

Male Rats ◽

Positive Role

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Adrenergic and Dopaminergic Control of Growth Hormone Secretion in Urethane Anesthetized Adult Male Rats

Hormone Research ◽

10.1159/000178915 ◽

1978 ◽

Vol 9 (4) ◽

pp. 208-224 ◽

Cited By ~ 1

Author(s):

W. Ruch ◽

P. Marbach ◽

A.L. Jaton ◽

B. Bucher ◽

W. Doepfner

Keyword(s):

Growth Hormone ◽

Adult Male ◽

Hormone Secretion ◽

Growth Hormone Secretion ◽

Male Rats ◽

Dopaminergic Control

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Interpulse growth hormone secretion in the episodic plasma profile causes the sex reversal of cytochrome P450s in senescent male rats

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.2434273100 ◽

2003 ◽

Vol 100 (25) ◽

pp. 15224-15228 ◽

Cited By ~ 36

Author(s):

R. N. Dhir ◽

B. H. Shapiro

Keyword(s):

Growth Hormone ◽

Hormone Secretion ◽

Growth Hormone Secretion ◽

Sex Reversal ◽

Cytochrome P450s ◽

Male Rats ◽

Plasma Profile

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DNA SYNTHESIS AND DEPLETION OF PROLACTIN IN THE PITUITARY GLAND OF THE MALE RAT

Journal of Endocrinology ◽

10.1677/joe.0.0770129 ◽

1978 ◽

Vol 77 (1) ◽

pp. 129-136 ◽

Cited By ~ 16

Author(s):

H. M. LLOYD ◽

J. M. JACOBI ◽

J. D. MEARES

Keyword(s):

Growth Hormone ◽

Dna Synthesis ◽

Hormone Secretion ◽

Growth Hormone Secretion ◽

Prolactin Secretion ◽

Male Rats ◽

Male Rat ◽

Serum Prolactin ◽

Inhibitory Effects ◽

Pituitary Prolactin

Haloperidol, bromocriptine and diethylstilboestrol dipropionate were given in various régimes to male rats to determine their effects on pituitary DNA synthesis, prolactin secretion and growth hormone secretion. Haloperidol increased serum prolactin but did not stimulate pituitary DNA synthesis or reduce pituitary prolactin concentrations. Haloperidol potentiated the effects of oestrogen on serum prolactin and on pituitary DNA synthesis; pituitary prolactin concentrations were greatly reduced, and growth hormone secretion was slightly inhibited. The inhibitory effects of bromocriptine in oestrogen-stimulated rats were demonstrated by smaller pituitary weights and decreased DNA synthesis; serum prolactin levels were lowered and pituitary prolactin concentrations were increased. Haloperidol, given to rats treated with oestrogen and bromocriptine, reversed the inhibitory effects of bromocriptine on DNA synthesis and serum prolactin; pituitary prolactin concentrations fell to well below normal. The results suggest that the haloperidol potentiation of oestrogeninduced pituitary DNA synthesis may depend upon stimulation of prolactin secretion together with reduction of intracellular prolactin levels.

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