Genetic Differences in Hypothalamic-Pituitary-Adrenal Axis Activity and Food Restriction-induced Hyperactivity in Three Inbred Strains of Rats

2005 ◽  
Vol 17 (11) ◽  
pp. 740-752 ◽  
Author(s):  
M. Duclos ◽  
M. Bouchet ◽  
A. Vettier ◽  
D. Richard
Keyword(s):  
Food Restriction ◽  
Inbred Strains ◽  
Genetic Differences ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

scholarly journals Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression

2010 ◽  
Vol 25 (5) ◽  
pp. 268-271 ◽  
Author(s):  
J.J. Mann ◽  
D.M. Currier
Keyword(s):  
Suicidal Behavior ◽  
Early Life ◽  
Life Experiences ◽  
Genetic Differences ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Epigenetic Mechanisms ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Epigenetic Effects ◽  
Pituitary Adrenal Axis

AbstractAlterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms.

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