Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression
2010 ◽
Vol 25
(5)
◽
pp. 268-271
◽
Keyword(s):
AbstractAlterations in a number of neurobiological systems have been associated with suicidal behavior including the serotonergic and noradrenergic systems and the hypothalamic-pituitary-adrenal axis. Altered functioning of these systems may stem from both genetic and developmental causes. Adversity in early-life has developmental consequences on these systems that persist into adulthood. Genetic differences may also contribute to alterations in functioning of neurobiological systems. Moreover, the interaction of early-life experiences of adversity and genetic vulnerability is increasingly thought to play a role, including via epigenetic mechanisms.
1992 ◽
Vol 32
(9)
◽
pp. 812-816
◽
2007 ◽
Vol 19
(1)
◽
2015 ◽
Vol 21
(11)
◽
pp. 1369-1378
◽
2013 ◽
Vol 12
(7)
◽
pp. 954-970
◽
2012 ◽
Vol 102
(3)
◽
pp. 434-441
◽
2014 ◽
Vol 26
(12)
◽
pp. 853-860
◽