Genes Encoding Key Regulators of Hypothalamic-Pituitary-Adrenal Axis Function: Interactions With Exposure to Childhood Trauma, and Adult Outcomes

2009 ◽  
Author(s):  
Bekh Bradley
Keyword(s):  
Childhood Trauma ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Adult Outcomes ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Genes Encoding ◽  
Pituitary Adrenal Axis

scholarly journals Childhood Trauma Is Associated With Hypothalamic-Pituitary-Adrenal Axis Responsiveness in Irritable Bowel Syndrome

2009 ◽  
Vol 137 (6) ◽  
pp. 1954-1962 ◽  
Author(s):  
Elizabeth J. Videlock ◽  
Mopelola Adeyemo ◽  
Arlene Licudine ◽  
Miyoshi Hirano ◽  
Gordon Ohning ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Childhood Trauma ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Irritable Bowel ◽  
Pituitary Adrenal Axis

Hypothalamic-pituitary-adrenal axis variants and childhood trauma influence anxiety sensitivity in South African adolescents

2017 ◽  
Vol 33 (2) ◽  
pp. 601-613 ◽  
Author(s):  
Jacqueline S. Womersley ◽  
Lindi I. Martin ◽  
Lize van der Merwe ◽  
Soraya Seedat ◽  
Sian M. J. Hemmings
Keyword(s):  
South African ◽  
Childhood Trauma ◽  
Anxiety Sensitivity ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

Findings with 0.25 mg Dexamethasone Suppression Test in Eating Disorders: Association with Childhood Trauma

CNS Spectrums ◽  
2007 ◽  
Vol 12 (9) ◽  
pp. 675-680 ◽  
Author(s):  
Marina Díaz-Marsá ◽  
José L. Carrasco ◽  
Elena Basurte ◽  
José I. Pastrana ◽  
Jerónimo Sáiz-Ruiz ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Childhood Trauma ◽  
Dexamethasone Suppression Test ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Suppression Test ◽  
Cortisol Suppression ◽  
Dexamethasone Suppression ◽  
Pituitary Adrenal Axis

ABSTRACTIntroduction: While both blunted and enhanced cortisol suppression following a dexamethasone suppression test (DST) are described in eating disorders, some evidence suggests that enhanced cortisol suppression might be associated with the presence of trauma history. The objective of this study is to investigate hypothalamic-pituitary-adrenal axis response to a modified DST in eating disorders and its relationship with childhood trauma.Methods: Fifty-two patients with eating disorders were studied with a 0.25 mg DST and with measures of childhood trauma.Conclusion: Patients with bulimia symptoms had significantly greater cortisol suppression than controls and restrictive anorexia patients (F=8.2, P<.05). Cortisol suppression was significantly correlated with intensity of childhood traumatic events (F=0.32, P<.05). Hypersensitive hypothalamic-pituitary-adrenal axis response to DST in eating disorders may be related with a history of childhood trauma and suggests some biological similarities with posttraumatic syndromes that should be further explored.

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