Amniotic fluid alpha2-macroglobulin and the antenatal diagnosis of spina bifida and anencephaly

2008 ◽  
Vol 8 (4) ◽  
pp. 297-301 ◽  
Author(s):  
D. J. H. Brock
Keyword(s):  
Spina Bifida ◽  
Amniotic Fluid ◽  
Antenatal Diagnosis

scholarly journals Amniotic fluid macrophages and the antenatal diagnosis of anencephaly and spina bifida.

1975 ◽  
Vol 12 (2) ◽  
pp. 135-137 ◽  
Author(s):  
G R Sutherland ◽  
D J Brock ◽  
J B Scrimgeour
Keyword(s):  
Spina Bifida ◽  
Amniotic Fluid ◽  
Antenatal Diagnosis

COMPARISON OF AMNIOTIC-FLUID AND MATERNAL SERUM ALPHA-FETOPROTEIN LEVELS IN THE EARLY ANTENATAL DIAGNOSIS OF SPINA BIFIDA AND ANENCEPHALY

The Lancet ◽  
1974 ◽  
Vol 303 (7855) ◽  
pp. 429-433 ◽  
Author(s):  
R. Harris ◽  
R.F. Jennison ◽  
A.J. Barson ◽  
K.M. Laurence ◽  
E. Ruoslahti ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Amniotic Fluid ◽  
Antenatal Diagnosis ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Serum Alpha Fetoprotein

AMNIOTIC-FLUID ALPHA-FETOPROTEIN IN THE ANTENATAL DIAGNOSIS OF SPINA BIFIDA

The Lancet ◽  
1973 ◽  
Vol 302 (7828) ◽  
pp. 522-525 ◽  
Author(s):  
LindseyD. Allan ◽  
Ian Donald ◽  
M.A. Ferguson-Smith ◽  
ElizabethM. Sweet ◽  
A.A.M. Gibson
Keyword(s):  
Spina Bifida ◽  
Amniotic Fluid ◽  
Antenatal Diagnosis ◽  
Alpha Fetoprotein

ALPHA-FETOPROTEIN IN ANTENATAL DIAGNOSIS OF ANENCEPHALY AND SPINA BIFIDA

The Lancet ◽  
1973 ◽  
Vol 301 (7813) ◽  
pp. 1187 ◽  
Author(s):  
J. Lorber ◽  
C.R. Stewart ◽  
A. Milford Ward
Keyword(s):  
Spina Bifida ◽  
Antenatal Diagnosis ◽  
Alpha Fetoprotein

Concanavalin A binding of alpha-fetoprotein in amniotic fluid as an aid in the diagnosis of neural tube defects.

1981 ◽  
Vol 27 (10) ◽  
pp. 1658-1660 ◽  
Author(s):  
P K Buamah ◽  
P Taylor ◽  
A M Ward
Keyword(s):  
Spina Bifida ◽  
Amniotic Fluid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Concanavalin A ◽  
Gestational Age ◽  
Alpha Fetoprotein ◽  
Normal Outcome ◽  
Fetal Malformations ◽  
Open Spina Bifida

Abstract Concanavalin A nonreactive alpha-fetoprotein was determined in samples of amniotic fluid from 16 abnormal pregnancies complicated by anencephaly (7), open spina bifida (6), intra-uterine death (1), anencephaly with exomphalos (1), or open spina bifida with exomphalos (1), and in amniotic fluid from 50 normal pregnancies with gestational age between 13 and 24 weeks. In all 16 cases with fetal malformations, the proportion of nonreactive alpha-fetoprotein was significantly decreased (median 5.3%) as compared with amniotic fluid from pregnancies with a normal outcome (median 39.7%). The results confirm that this measurement is useful in the diagnosis of neural tube defects, especially when the concentration of alpha-fetoprotein in amniotic fluid is normal or only slightly above normal and gestational age is uncertain.

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