Preparation of a multiple antigen glycopeptide (MAG) carrying the Tn antigen. A possible approach to a synthetic carbohydrate vaccine

2009 ◽  
Vol 49 (6) ◽  
pp. 620-625 ◽  
Author(s):  
SYLVIE BAY ◽  
RICHARD LO-MAN ◽  
EDUARDO OSINAGA ◽  
HIROSHI NAKADA ◽  
CLAUDE LECLERC ◽  
...  
Keyword(s):  
Tn Antigen ◽  
Multiple Antigen ◽  
Antigen A ◽  
Synthetic Carbohydrate

Corrigendum to: “Structural basis for the specificity of basic winged bean lectin for the Tn-antigen: A crystallographic, thermodynamic and modelling study” [FEBS Lett. 579 (2005) 6775-6780]

FEBS Letters ◽  
2006 ◽  
Vol 580 (11) ◽  
pp. 2808-2808
Author(s):  
Kiran A. Kulkarni ◽  
Sharmistha Sinha ◽  
Samiksha Katiyar ◽  
Avadhesha Surolia ◽  
Mamannamana Vijayan ◽  
...  
Keyword(s):  
Winged Bean ◽  
Structural Basis ◽  
Tn Antigen ◽  
Antigen A ◽  
Modelling Study

scholarly journals Tn antigen, a marker of potential for metastasis of uterine cervix cancer cells

Cancer ◽  
1993 ◽  
Vol 72 (1) ◽  
pp. 154-159 ◽  
Author(s):  
Tsutomu Hirao ◽  
Yasuki Sakamoto ◽  
Masaharu Kamada ◽  
Shin-Ichi Hamada ◽  
Toshihiro Aono
Keyword(s):  
Cancer Cells ◽  
Uterine Cervix ◽  
Cervix Cancer ◽  
Tn Antigen ◽  
Uterine Cervix Cancer ◽  
Antigen A

scholarly journals Efficient and Reproducible Synthesis of an Fmoc-protected Tn Antigen

2021 ◽  
Author(s):  
Michael R. Reynolds ◽  
Sabrina Piazza ◽  
Jonathan Chiaramonte ◽  
Fabiola A. Chapa-Villarreal ◽  
John Trant
Keyword(s):  
Total Synthesis ◽  
Peptide Synthesis ◽  
Building Block ◽  
Large Scale ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Tn Antigen ◽  
Palladium Catalyzed ◽  
Glycosyl Donor ◽  
Antigen A

The total synthesis of the Thomsen-nouveau (Tn) antigen, a tumour-associated O-linked mucin glycopeptide, was achieved through a concise route. The key glycosylation step proved challenging to reproduce from the literature precedents and was most reliably accomplished using a palladium-catalyzed coupling between the glycosyl donor and Fmoc-functionalized serine acceptor to form the target in moderate yields. This is, to the best of our knowledge, the shortest synthesis reported from galactose for preparing this essential building block for large-scale solid phase peptide synthesis.

Synthetic carbohydrate vaccines: Synthesis and immunogenicity of Tn antigen conjugates

1994 ◽  
Vol 2 (11) ◽  
pp. 1119-1132 ◽  
Author(s):  
Tatsushi Toyokuni ◽  
Sen-itiroh Hakomori ◽  
Anil K. Singhal
Keyword(s):  
Tn Antigen ◽  
Synthetic Carbohydrate ◽  
Carbohydrate Vaccines

scholarly journals Structural basis for the specificity of basic winged bean lectin for the Tn-antigen: A crystallographic, thermodynamic and modelling study

FEBS Letters ◽  
2005 ◽  
Vol 579 (30) ◽  
pp. 6775-6780 ◽  
Author(s):  
Kiran A. Kulkarni ◽  
Sharmistha Sinha ◽  
Samiksha Katiyar ◽  
Avadhesha Surolia ◽  
Mamannamana Vijayan ◽  
...  
Keyword(s):  
Winged Bean ◽  
Structural Basis ◽  
Tn Antigen ◽  
Antigen A ◽  
Modelling Study

scholarly journals Efficient and Reproducible Synthesis of an Fmoc-protected Tn Antigen

2021 ◽  
Author(s):  
Michael R. Reynolds ◽  
Sabrina Piazza ◽  
Jonathan Chiaramonte ◽  
Fabiola A. Chapa-Villarreal ◽  
John Trant
Keyword(s):  
Total Synthesis ◽  
Peptide Synthesis ◽  
Building Block ◽  
Large Scale ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Tn Antigen ◽  
Palladium Catalyzed ◽  
Glycosyl Donor ◽  
Antigen A

The total synthesis of the Thomsen-nouveau (Tn) antigen, a tumour-associated O-linked mucin glycopeptide, was achieved through a concise route. The key glycosylation step proved challenging to reproduce from the literature precedents and was most reliably accomplished using a palladium-catalyzed coupling between the glycosyl donor and Fmoc-functionalized serine acceptor to form the target in moderate yields. This is, to the best of our knowledge, the shortest synthesis reported from galactose for preparing this essential building block for large-scale solid phase peptide synthesis.

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