cervix cancer
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2022 ◽  
Vol 3 (1) ◽  
pp. 01-09
Author(s):  
Azab Elsayed Azab ◽  
Fikry Ali Abushofa ◽  
Hajar Musa Al Ghawi

Background: Cervix cancer is one of the most common cancers in women worldwide, and is the third most common malignant disease in women. It is one of the main health problems in Libyan women. Blood act as a pathological reflector of the status of exposed patient to infections and other conditions. Laboratory tests on the blood are vital tools that help detect any deviation from normal in the human body As the disease progresses, changes appear in haematological parameters which have been of relevant consideration in context of cancer patients. Objectives: The present study aimed to evaluate the alterations in haematological parameters among cervical cancer patients in Sabratha National Cancer Institute. Subjects and Methods: The present study was conducted on 150 cervical cancer patients, attending the National Cancer Institute of Sabratha from the 11th February, 2006 to the 3rd February, 2020. This study was approved by the Research and Ethical Committee of Sabratha University and Sabratha National Cancer Institute. Age was extracted from patient files. Also, 60 healthy individuals without any chronic disease were recruited for the control group. Blood samples were collected by vein puncture, 3 ml of venous blood withdrawn from each participant in the study by using disposable syringes under aseptic technique; they then transferred to a sterile EDTA tube, for complete blood count. The statistical significance of differences between groups was evaluated with the Mann Whitney U test. Results: The results showed that the mean age of the cervix cancer patients was 53.37±11.6 years.RBCs count, hemoglobin concentration, Hct value, MCH, MCHC, and lymphocytes % were significantly (P<0.01) decreased compared with the healthy individuals. On the other hand, leukocytes and platelets count, mixed %, neutrophils %, PLTs/Lymph, and Neutrophils/Lymphocytes ratios were significantly increased as compared with the healthy individuals. Conclusion: It can be concluded that a significant increase in leukocytes and platelets count, mixed %, neutrophils %, and the studied inflammation related haematological parameters and a significant decreased in lymphocytes %, RBCs count and most its indices. Further haematological studies are needed to confirm these results. Also, there is need to routinely monitor the haematological parameters and among cervical cancer patients.


RSC Advances ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 483-497
Author(s):  
Iqubal Singh ◽  
Vijay Luxami ◽  
Diptiman Choudhury ◽  
Kamaldeep Paul

Conjugates of naphthalimide, benzothiazole, and indole moieties are synthesized that show excellent cytotoxicity against A549 (lung), MCF7 (breast), and HeLa (cervix) cancer cell lines with IC50 values in the range of 0.14–8.59 μM.


2021 ◽  
Vol 51 (4) ◽  
pp. 48-51
Author(s):  
L. A. Kolomiyets ◽  
O. N. Churuksayeva ◽  
L. N. Urazova ◽  
N. V. Sevostyanova

In order to estimate the colposcopic manifestations of cervical oncotropic human papilloma-virus (HPV)-infection, a total of 693 patients were examimed. Among them, there were 298 patients with benign tumors pathology, 57 patients with 1-3 Grade cervical dysplasia of mucosa, 50 patients with uterine cervix cancer, 288 healthy women. All patients underwent bimanual examination, taking of cervical smears for cytological examination and uterine cervix colposcopy. Diagnosis for HPV16/18 infection was made by the method of polimerase chain reaction. А large variety in colposcopic manifestations of HPV-infection was found, namely: areas of atypical vessels, leukoplakia sites,fields of atypical epithelium, iodine-negative sites. It was related to the influence of oncogenic types of HPV infection. In these patients,fields of atypical epithelium, atypical vessels, iodinenegative areas were observed 1.2, 2.5, 10.5 times more frequently, respectively. It was found that all varieties of papillomas occurred among patients with pathology, whereas flat condylomas presenting the most difficulties of or diagnosis prevailed in patients with cervical neoplasms and uterine cervix cancer The most pronounced colposcopic evidences of uterine cervix epithelium malignancy were observed in patients with virus-positive uterine cervix cancer.


2021 ◽  
pp. 284-292
Author(s):  
Eric Leblanc ◽  
Fabrice Narducci ◽  
Delphine Hudry ◽  
Abel Cordoba ◽  
Florence Le Tinier ◽  
...  

Author(s):  
Liyun Yang ◽  
Mostafa Heidari Majd ◽  
Fereshteh Shiri ◽  
Somaye Shahraki ◽  
Pouya Karimi

2021 ◽  
Author(s):  
AF Rave Ramirez ◽  
D González García-Cano ◽  
O Arencibia Sanchez ◽  
M Laseca Modrego ◽  
A Martín Martínez ◽  
...  

2021 ◽  
pp. 195-217
Author(s):  
Anthony B. Miller
Keyword(s):  

Author(s):  
Chuanrong Yu ◽  
Mostafa Heidari Majd ◽  
Fereshteh Shiri ◽  
Somaye Shahraki ◽  
Pouya Karimi

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