Towards a Fully Synthetic Carbohydrate-Based Anticancer Vaccine: Synthesis and Immunological Evaluation of a Lipidated Glycopeptide Containing the Tumor-Associated Tn Antigen

2005 ◽  
Vol 44 (37) ◽  
pp. 5985-5988 ◽  
Author(s):  
Therese Buskas ◽  
Sampat Ingale ◽  
Geert-Jan Boons
Keyword(s):  
Tn Antigen ◽  
Synthetic Carbohydrate ◽  
Anticancer Vaccine ◽  
Immunological Evaluation

scholarly journals Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue

2020 ◽  
Vol 11 (17) ◽  
pp. 4488-4498
Author(s):  
Carlo Pifferi ◽  
Ane Ruiz-de-Angulo ◽  
David Goyard ◽  
Claire Tiertant ◽  
Nagore Sacristán ◽  
...  
Keyword(s):  
Igg Antibodies ◽  
Tn Antigen ◽  
Cellular Immune Responses ◽  
Anticancer Vaccines ◽  
Specific Igg ◽  
Cellular Immune ◽  
New Generation ◽  
Anticancer Vaccine ◽  
Immunological Evaluation ◽  
Specific Igg Antibodies

A fully-synthetic anticancer vaccine candidate incorporating an hexadecavalent Tn antigen analogue display via oxime linkages induced tumor-specific IgG antibodies and cellular immune responses in mice coadministered with QS-21 as an adjuvant.

Synthesis and immunological evaluation of N-acyl modified Globo H derivatives as anticancer vaccine candidates

2021 ◽  
Author(s):  
Canjia Zhai ◽  
Xiu-Jing Zheng ◽  
Cheng-Cheng Song ◽  
Xin-Shan Ye
Keyword(s):  
T Cell ◽  
Carbohydrate Antigen ◽  
Vaccine Candidates ◽  
Antitumor Vaccine ◽  
Cancer Immunotherapies ◽  
Anticancer Vaccine ◽  
Immunological Evaluation

Globo H is a tumor-associated carbohydrate antigen (TACA), which serves as a valuable target for antitumor vaccine or cancer immunotherapies. However, most TACAs are T-cell-independent and they cannot induce powerful...

Preparation of a multiple antigen glycopeptide (MAG) carrying the Tn antigen. A possible approach to a synthetic carbohydrate vaccine

2009 ◽  
Vol 49 (6) ◽  
pp. 620-625 ◽  
Author(s):  
SYLVIE BAY ◽  
RICHARD LO-MAN ◽  
EDUARDO OSINAGA ◽  
HIROSHI NAKADA ◽  
CLAUDE LECLERC ◽  
...  
Keyword(s):  
Tn Antigen ◽  
Multiple Antigen ◽  
Antigen A ◽  
Synthetic Carbohydrate

Synthesis and immunological evaluation of N-acyl modified Tn analogues as anticancer vaccine candidates

2016 ◽  
Vol 24 (4) ◽  
pp. 915-920 ◽  
Author(s):  
Chengcheng Song ◽  
Shuang Sun ◽  
Chang-Xin Huo ◽  
Qin Li ◽  
Xiu-Jing Zheng ◽  
...  
Keyword(s):  
Vaccine Candidates ◽  
Anticancer Vaccine ◽  
Immunological Evaluation

Chemoselective Assembly and Immunological Evaluation of Multiepitopic Glycoconjugates Bearing Clustered Tn Antigen as Synthetic Anticancer Vaccines

2005 ◽  
Vol 16 (5) ◽  
pp. 1149-1159 ◽  
Author(s):  
Saulius Grigalevicius ◽  
Sabine Chierici ◽  
Olivier Renaudet ◽  
Richard Lo-Man ◽  
Edith Dériaud ◽  
...  
Keyword(s):  
Tn Antigen ◽  
Anticancer Vaccines ◽  
Immunological Evaluation

Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen

2004 ◽  
Vol 14 (13) ◽  
pp. 3567-3570 ◽  
Author(s):  
Sophie Vichier-Guerre ◽  
Richard Lo-Man ◽  
Valérie Huteau ◽  
Edith Dériaud ◽  
Claude Leclerc ◽  
...  
Keyword(s):  
Tn Antigen ◽  
Immunological Evaluation

ChemInform Abstract: Synthesis and Immunostimulating Activity of a Thioglycolipopeptide Glycomimetic as a Potential Anticancer Vaccine Derived from Tn Antigen.

ChemInform ◽  
2010 ◽  
Vol 31 (46) ◽  
pp. no-no
Author(s):  
Ennio Bousquet ◽  
Angelo Spadaro ◽  
Maria S. Pappalardo ◽  
Renato Bernardini ◽  
Rosalba Romeo ◽  
...  
Keyword(s):  
Tn Antigen ◽  
Immunostimulating Activity ◽  
Anticancer Vaccine

Synthetic carbohydrate vaccines: Synthesis and immunogenicity of Tn antigen conjugates

1994 ◽  
Vol 2 (11) ◽  
pp. 1119-1132 ◽  
Author(s):  
Tatsushi Toyokuni ◽  
Sen-itiroh Hakomori ◽  
Anil K. Singhal
Keyword(s):  
Tn Antigen ◽  
Synthetic Carbohydrate ◽  
Carbohydrate Vaccines

Calix[4]arene Decorated with Four Tn Antigen Glycomimetic Units and P3CS Immunoadjuvant: Synthesis, Characterization, and Anticancer Immunological Evaluation

2008 ◽  
Vol 19 (3) ◽  
pp. 751-758 ◽  
Author(s):  
Corrada Geraci ◽  
Grazia M. L. Consoli ◽  
Eva Galante ◽  
Ennio Bousquet ◽  
Maria Pappalardo ◽  
...  
Keyword(s):  
Tn Antigen ◽  
Immunological Evaluation
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