EFFECT OF FELODIPINE TREATMENT AND WITHDRAWAL ON BLOOD PRESSURE AND CARDIOVASCULAR STRUCTURE IN NEW ZEALAND GENETICALLY HYPERTENSIVE RATS

Abstract. Renal water and electrolyte handling and related plasma hormone levels were measured in male and female New Zealand genetically hypertensive and normotensive rats, in an attempt to etablish any potentially important sex-related differences in these parameters. Male hypertensive rats had higher blood pressure than female hypertensive rats, but normotensive rats showed no such sex difference. Both groups of males had higher fluid turnover rates than respective females, and this was associated with raised plasma vasopressin in hypertensive males. Female hypertensive rats excreted more sodium, potassium and chloride in association with lower plasma aldosterone and higher corticosterone levels compared with the other groups. Plasma electrolytes did not differ between the four groups, but plasma osmolality was higher in hypertensive than normotensive rats of both sexes. A higher rate of electrolyte loss and lower fluid turnover in association with reduced plasma vasopressin may contribute to the lower blood pressure of female compared with male hypertensive rats.

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Progesterone Is Not Responsible for the Blood Pressure Fall in Late-Pregnant New Zealand Genetically Hypertensive Rats

Experimental Biology and Medicine ◽

10.3181/00379727-176-41846 ◽

1984 ◽

Vol 176 (1) ◽

pp. 84-87 ◽

Cited By ~ 1

Author(s):

R. M. Boyd ◽

P. G. Baer

Keyword(s):

Blood Pressure ◽

New Zealand ◽

Hypertensive Rats ◽

Blood Pressure Fall ◽

Genetically Hypertensive Rats ◽

Pressure Fall ◽

Genetically Hypertensive

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Blood Pressure in Genetically Hypertensive Rats

Hypertension ◽

10.1161/01.hyp.26.3.452 ◽

1995 ◽

Vol 26 (3) ◽

pp. 452-459 ◽

Cited By ~ 57

Author(s):

Anne O. Davidson ◽

Nicholas Schork ◽

Bryon C. Jaques ◽

Andrew W. Kelman ◽

Roger G. Sutcliffe ◽

...

Keyword(s):

Blood Pressure ◽

Hypertensive Rats ◽

Genetically Hypertensive Rats ◽

Genetically Hypertensive

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NE turnover in genetically hypertensive rats of Lyon strain. I. Brain nuclei

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1988.255.4.h729 ◽

1988 ◽

Vol 255 (4) ◽

pp. H729-H735 ◽

Cited By ~ 1

Author(s):

M. Sautel ◽

J. Sacquet ◽

M. Vincent ◽

J. Sassard

Keyword(s):

Blood Pressure ◽

Hypothalamic Nucleus ◽

Primary Role ◽

Hypertensive Rats ◽

Brain Areas ◽

Brain Nuclei ◽

Genetically Hypertensive Rats ◽

Low Blood Pressure ◽

Genetically Hypertensive

Several indirect evidences of alterations in the central catecholaminergic structures were obtained in genetically hypertensive rats. Because they could be of pathogenetic value, we measured, in the present work, the in vivo turnover (TO) of norepinephrine (NE) in brain areas of 5- and 22-wk-old genetically hypertensive (LH) rats of the Lyon strain, and their simultaneously selected normotensive (LN) and low blood pressure (LL) controls. Among the changes observed, the increased TO of NE in the A2 and A6 regions of 5-wk-old LH rats and its decrease in the posteroventral hypothalamic nucleus of 22-wk-old LH animals appeared likely to compensate for hypertension. On the contrary, the decreased TO of NE in the anterior hypothalamic nucleus observed at 5 wk and in the A6 and A1 areas at 22 wk of age in LH rats could participate in the development or the maintenance of hypertension. Above all, it was postulated that the increased TO of NE found in the A7 region of 5-wk-old LH rats could play a primary role in the pathogenesis of hypertension in the Lyon model.

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